| C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages. | C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
Wright O, Harris A, Nguyen VD, Zhou Y, Durand M, Jayyaratnam A, Gormley D, O'Neill LAJ, Triantafilou K, Nichols EM, Booty LM., Free PMC Article | 01/12/2024 |
| C5L2 modulates BDNF production in human dental pulp stem cells via p38alpha pathway. | C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.
Irfan M, Chung S., Free PMC Article | 01/14/2023 |
| Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients. | Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
Emtenani S, Holtsche MM, Stahlkopf R, Seiler DL, Burn T, Liu H, Parker M, Yilmaz K, Dikmen HO, Lang MH, Sadik CD, Karsten CM, van Beek N, Ludwig RJ, Köhl J, Schmidt E., Free PMC Article | 12/10/2022 |
| C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages. | C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
Li XX, Clark RJ, Woodruff TM. | 03/27/2021 |
| Expression of C5aR1 and C5aR2 in whole blood was significantly attenuated by IL-6R-inhibition in non-ST-elevation myocardial infarction patients. | IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.
Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE., Free PMC Article | 10/5/2019 |
| Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China. | Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
Zheng YY, Xie X, Ma YT, Fu ZY, Ma X, Yang YN, Li XM, Pan S, Adi D, Chen BD, Liu F., Free PMC Article | 03/3/2018 |
| Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation. | New concepts on the therapeutic control of complement anaphylatoxin receptors.
Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM. | 10/28/2017 |
| negative regulator of BDNF secretion by pulp fibroblasts under carious teeth | C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
Chmilewsky F, About I, Chung SH. | 05/27/2017 |
| All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls. | Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.
Alharbi KK., Free PMC Article | 11/12/2016 |
| C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis. | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
Xu R, Lin F, Bao C, Huang H, Ji C, Wang S, Jin L, Sun L, Li K, Zhang Z, Wang FS., Free PMC Article | 10/1/2016 |
| this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a beta-arrestin-2-, PI3K-, and ERK-dependent signaling pathway in these cells. | The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Pundir P, MacDonald CA, Kulka M. | 01/2/2016 |
| C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment. | C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment.
Croker DE, Halai R, Kaeslin G, Wende E, Fehlhaber B, Klos A, Monk PN, Cooper MA. | 04/11/2015 |
| prominent C5L2 expression in advanced atherosclerotic stages directly correlates with high levels of proinflammatory cytokines | High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques.
Vijayan S, Asare Y, Grommes J, Soehnlein O, Lutgens E, Shagdarsuren G, Togtokh A, Jacobs MJ, Fischer JW, Bernhagen J, Weber C, Schober A, Shagdarsuren E. | 04/4/2015 |
| The present study has extended the mutation spectrum of C5L2, and Thr196Asn mutations in C5L2 were associated with retinitis pigmentosa and serum lipid levels. | A novel mutation in C5L2 gene was associated with hyperlipidemia and retinitis pigmentosa in a Chinese family.
Qu LH, Jin X, Li LM, Li SY, Xie HP., Free PMC Article | 11/29/2014 |
| C5aR and C5L2 may have roles in adiposity in women | Association of immune and metabolic receptors C5aR and C5L2 with adiposity in women.
Poursharifi P, Rezvani R, Gupta A, Lapointe M, Marceau P, Tchernof A, Cianflone K., Free PMC Article | 10/18/2014 |
| A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population. | A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population.
Zheng YY, Xie X, Ma YT, Yang YN, Fu ZY, Li XM, Ma X, Chen BD, Liu F., Free PMC Article | 07/12/2014 |
| our study indicates that 698C>T polymorphism of C5L2 gene is associated with the T2DM in individuals of Saudi population which was found to be similar with other studies. | Circulating C5L2 gene polymorphism is associated with type 2 diabetes mellitus in Saudi population.
Alharbi KK, Khan IA, Syed R. | 06/14/2014 |
| C5L2 may be implicated in the pro-inflammatory role in C5a-primed neutrophils for ANCA-induced activation. | A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation.
Hao J, Wang C, Yuan J, Chen M, Zhao MH., Free PMC Article | 01/25/2014 |
| C5L2 receptors are abundant in neurofibrillary tangles in Alzheimer's disease brain compared to controls. | Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology.
Fonseca MI, McGuire SO, Counts SE, Tenner AJ., Free PMC Article | 10/26/2013 |
| The results suggest that insulin sensitivity may be permissive for coupling of C5L2 levels to lipid storage and utilization. | Relationship of C5L2 receptor to skeletal muscle substrate utilization.
Roy C, Paglialunga S, Schaart G, Moonen-Kornips E, Meex RC, Phielix E, Hoeks J, Hesselink MK, Cianflone K, Schrauwen P., Free PMC Article | 09/7/2013 |
| C5L2 has been recently demonstrated to physically interact with both C5aR and beta-arrestin to negatively regulate C5aR signaling toward an anti-inflammatory manner | C5L2: a controversial receptor of complement anaphylatoxin, C5a.
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM. | 04/27/2013 |
| C5L2 was expressed in the kidney and localized to the distal convoluted tubule and connecting tubule. | Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney.
van Werkhoven MB, Damman J, Daha MR, Krikke C, van Goor H, van Son WJ, Hillebrands JL, van Dijk MC, Seelen MA. | 01/12/2013 |
| genetic association studies in the Chinese Han population: Data suggest that an SNP in C5L2 (C698T) is associated with type 2 diabetes mellitus; 698CT heterozygotes exhibited increased serum triglyceride levels. | Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population.
Zheng YY, Xie X, Ma YT, Yang YN, Fu ZY, Li XM, Ma X, Chen BD, Liu F. | 07/21/2012 |
| The aim of this study was to investigate the genetic alterations and mRNA expression pattern of C5aR and C5L2 genes in neutrophils from attack-free familial Mediterranean fever patients. | Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever.
Apostolidou E, Kambas K, Chrysanthopoulou A, Kourtzelis I, Speletas M, Ritis K, Mitroulis I. | 07/14/2012 |
| Neither the familial combined hyperlipidemia subjects nor the type 2 diabetes patients were found to have the S323I variant of the C5L2 gene. | S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes.
Zheng YY, Xie X, Ma YT, Yang YN, Fu ZY, Li XM, Liu F, Yang SJ, Ma X, Chen BD. | 06/9/2012 |