| Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis. | Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.
Pils M, Rutsch J, Eren F, Engberg G, Piehl F, Cervenka S, Sellgren C, Troßbach S, Willbold D, Erhardt S, Bannach O, Korth C. | 12/20/2023 |
| Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study. | Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study.
Habibi S, Yaghoubzad-Maleki M, Heshmati E, Khalifeh K. | 11/27/2023 |
| The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population. | The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population.
Li W, Jiang H, Chen X, Yang K, Deng X, Tang Z, Hu Z, Zhang X, Lin S, Zou Y, Wu H., Free PMC Article | 12/3/2022 |
| Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive Flexibility and Social Behaviors in a Transgenic Rat Model. | Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive Flexibility and Social Behaviors in a Transgenic Rat Model.
Wang AL, Chao OY, Nikolaus S, Lamounier-Zepter V, Hollenberg CP, Lubec G, Trossbach SV, Korth C, Huston JP. | 06/18/2022 |
| Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia. | Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia.
Fricke-Galindo I, Pérez-Aldana BE, Macías-Kauffer LR, González-Arredondo S, Dávila-Ortiz de Montellano D, Aviña-Cervantes CL, López-López M, Rodríguez-Agudelo Y, Monroy-Jaramillo N. | 06/11/2022 |
| Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. | Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.
Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R 3rd, Narayan S, Hou Z, Economides AN, Hikida T, Wetsel WC, Deisseroth K, Mori S, Brandon NJ, Tanaka M, Ishizuka K, Houslay MD, Saudou F, Dzirasa K, Sawa A, Tomoda T., Free PMC Article | 05/21/2022 |
| Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia. | Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia.
Guardiola-Ripoll M, Sotero-Moreno A, Almodóvar-Payá C, Hostalet N, Guerrero-Pedraza A, Ramiro N, Ortiz-Gil J, Arias B, Madre M, Soler-Vidal J, Salvador R, McKenna PJ, Pomarol-Clotet E, Fatjó-Vilas M., Free PMC Article | 05/14/2022 |
| The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment. | The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment.
Wang J, Su P, Yang J, Xu L, Yuan A, Li C, Zhang T, Dong F, Zhou J, Samsom J, Wong AHC, Liu F., Free PMC Article | 04/9/2022 |
| Effects of DISC1 on Alzheimer's disease cell models assessed by iTRAQ proteomics analysis. | Effects of DISC1 on Alzheimer's disease cell models assessed by iTRAQ proteomics analysis.
Lu J, Huang R, Peng Y, Wang H, Feng Z, Fan Y, Zeng Z, Wang Y, Wei J, Wang Z., Free PMC Article | 02/5/2022 |
| The DISC1-Girdin complex - a missing link in signaling to the T cell cytoskeleton. | The DISC1-Girdin complex - a missing link in signaling to the T cell cytoskeleton.
Maskalenko N, Nath S, Ramakrishnan A, Anikeeva N, Sykulev Y, Poenie M., Free PMC Article | 07/31/2021 |
| Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3beta) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. | Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.
Saundh SL, Patnaik D, Gagné S, Bishop JA, Lipsit S, Amat S, Pujari N, Nambisan AK, Bigsby R, Murphy M, Tsai LH, Haggarty SJ, Leung AK. | 07/10/2021 |
| Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. | Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity.
Nani JV, Fonseca MC, Engi SA, Perillo MG, Dias CS, Gazarini ML, Korth C, Cruz FC, Hayashi MA. | 06/26/2021 |
| Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. | Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.
Wang X, Ye F, Wen Z, Guo Z, Yu C, Huang WK, Rojas Ringeling F, Su Y, Zheng W, Zhou G, Christian KM, Song H, Zhang M, Ming GL., Free PMC Article | 06/12/2021 |
| The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity. | The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity.
Su P, Zhang H, Wong AHC, Liu F., Free PMC Article | 06/5/2021 |
| Expression of Disrupted-in-schizophrenia 1 protein and related inflammatory factors in refractory temporal lobe epilepsy in children. | Expression of Disrupted-in-schizophrenia 1 protein and related inflammatory factors in refractory temporal lobe epilepsy in children.
Feng BH, Huang CB, Yuan ZF. | 05/8/2021 |
| Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia. | Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia.
Fu X, Zhang G, Liu Y, Zhang L, Zhang F, Zhou C., Free PMC Article | 11/21/2020 |
| HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells. | HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells.
Chen Y, Yan Q, Zhou P, Li S, Zhu F. | 09/12/2020 |
| Evidence of association of the DISC1 interactome gene set with schizophrenia from GWAS. | Evidence of association of the DISC1 interactome gene set with schizophrenia from GWAS.
Facal F, Costas J. | 08/29/2020 |
| DISC1 is a novel mitophagy receptor, which protects synaptic plasticity from Abeta accumulation-induced toxicity through promoting mitophagy. | Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.
Wang ZT, Lu MH, Zhang Y, Ji WL, Lei L, Wang W, Fang LP, Wang LW, Yu F, Wang J, Li ZY, Wang JR, Wang TH, Dou F, Wang QW, Wang XL, Li S, Ma QH, Xu RX., Free PMC Article | 04/4/2020 |
| PHNO imaging study found no association of DISC1 SNPs with D2 /D3 receptor availability. | Disrupted-in-schizophrenia 1 functional polymorphisms and D(2) /D(3) receptor availability: A [(11) C]-(+)-PHNO imaging study.
Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD., Free PMC Article | 03/14/2020 |
| These findings provide new insight into abnormalities of kinase networks in schizophrenia and suggest possible targets for disease intervention. | Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia.
Bentea E, Depasquale EAK, O'Donovan SM, Sullivan CR, Simmons M, Meador-Woodruff JH, Zhou Y, Xu C, Bai B, Peng J, Song H, Ming GL, Meller J, Wen Z, McCullumsmith RE., Free PMC Article | 02/15/2020 |
| Endogenous DISC1 interactomes within iPSC-derived human neural progenitor cells and astrocytes are able to provide context to DISC1 function in a cell type-specific setting relevant to neural development and enables the integration of psychiatric disease risk factors within a set of defined molecular functions. | Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.
Wilkinson B, Evgrafov OV, Zheng D, Hartel N, Knowles JA, Graham NA, Ichida JK, Coba MP., Free PMC Article | 02/1/2020 |
| two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention. | Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia.
Liu CM, Liu YL, Hwu HG, Fann CS, Yang UC, Hsu PC, Chang CC, Chen WJ, Hwang TJ, Hsieh MH, Liu CC, Chien YL, Lin YT, Tsuang MT. | 12/7/2019 |
| that the transcript levels of DISC1 and DISC2 long non-coding RNAs could be considered as a good putative biomarker for individuals with bipolar disorder | Significant increasing of DISC2 long non-coding RNA expression as a potential biomarker in bipolar disorder.
Naghavi-Gargari B, Zahirodin A, Ghaderian SMH, Shirvani-Farsani Z. | 09/7/2019 |
| DISC1 rs821616 Ser homozygotes exhibited a higher striatal Kicer compared with Cys homozygotes and heterozygotes. Activation of ERK1/2 stimulates tyrosine hydroxylase activity for dopamine synthesis and increasing risk for psychosis. | The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD., Free PMC Article | 05/25/2019 |