| Decreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma. | Decreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma.
Zhang Q, Pan J, An F, Nie H, Zhan Q., Free PMC Article | 02/19/2022 |
| Mitochondrial membrane potential is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn(2+) entry through the Zip1-MCU complex. After division, healthy mitochondria restore MMP levels and participate in the fusion-fission cycle again, but mitochondria that fail to restore MMP undergo mitophagy. | Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System.
Cho HM, Ryu JR, Jo Y, Seo TW, Choi YN, Kim JH, Chung JM, Cho B, Kang HC, Yu SW, Yoo SJ, Kim H, Sun W. | 06/1/2019 |
| Despite the fact that these preliminary findings are unlikely to be of much diagnostic significance, these findings suggest that hZip1 plays a fundamental role in the carcinogenesis of mucinous tumors. | Persistent low expression of hZip1 in mucinous carcinomas of the ovary, colon, stomach and lung.
Desouki MM, Franklin RB, Costello LC, Fadare O., Free PMC Article | 08/27/2016 |
| Data indicate that zinc transporters ZnT1 and Zip1 were the most abundantly expressed zinc transporters in leukocytes. | The alteration of zinc transporter gene expression is associated with inflammatory markers in obese women.
Noh H, Paik HY, Kim J, Chung J. | 05/16/2015 |
| Data suggest that high zrt- and Irt-like protein 1 (hZIP1) expression may be an indicator of good prognosis in clear cell renal cell carcinoma (ccRCC). | hZIP1 that is down-regulated in clear cell renal cell carcinoma is negatively associated with the malignant potential of the tumor.
Dong X, Kong C, Zhang Z, Liu X, Zhan B, Chen Z, Shi D. | 05/16/2015 |
| The effect of zinc administered for 27 days on the expression of ZIP1 in peripheral white blood cells is reported. | Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels.
Méndez RO, Santiago A, Yepiz-Plascencia G, Peregrino-Uriarte AB, de la Barca AM, García HS., Free PMC Article | 01/24/2015 |
| RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. | hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1).
Zou J, Milon BC, Desouki MM, Costello LC, Franklin RB., Free PMC Article | 01/10/2015 |
| Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls. | Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature.
Sun P, Wang S, Jiang Y, Tao Y, Tian Y, Zhu K, Wan H, Zhang L, Zhang L. | 04/26/2014 |
| Data indicate that the expression levels of ZnT and ZIP families in the three cell lines, when treated with high concentration of ZnSO4, increased and decreased corresponding to their functions, respectively. | Effects of exogenous zinc on cell cycle, apoptosis and viability of MDAMB231, HepG2 and 293 T cells.
Wang YH, Li KJ, Mao L, Hu X, Zhao WJ, Hu A, Lian HZ, Zheng WJ. | 03/15/2014 |
| The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. | Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.
Beyer N, Coulson DT, Heggarty S, Ravid R, Hellemans J, Irvine GB, Johnston JA. | 08/18/2012 |
| The metallothionein gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p=0.01 in obese patients. | Expression of the zinc transporters genes and metallothionein in obese women.
dos Santos Rocha PB, de Castro Amorim A, de Sousa AF, do Monte SJ, da Mata Sousa LC, do Nascimento Nogueira N, Neto JM, do Nascimento Marreiro D. | 04/14/2012 |
| Differentiated Caco-2 cells tolerate significantly higher levels of zinc compared to undifferentiated Caco-2 cells, which was accompanied by upregulated ZnT-1 and downregulated ZIP1 levels. | Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells.
Zemann N, Zemann A, Klein P, Elmadfa I, Huettinger M. | 12/24/2011 |
| GSPE and EGCG enhance the expression of cellular zinc importers ZIP1 (SLC39A1). | Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells.
Quesada IM, Bustos M, Blay M, Pujadas G, Ardèvol A, Salvadó MJ, Bladé C, Arola L, Fernández-Larrea J. | 04/30/2011 |
| the expression of human Zn transporter1 (hZIP1) appears to correlate with the Zn levels in the prostate glands and may be the major Zn regulator in this organ. | Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands.
Johnson LA, Kanak MA, Kajdacsy-Balla A, Pestaner JP, Bagasra O. | 02/26/2011 |
| Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. | Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells.
Milon BC, Agyapong A, Bautista R, Costello LC, Franklin RB., Free PMC Article | 03/22/2010 |
| ZIP is a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis | ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y., Free PMC Article | 01/21/2010 |
| The core promoter region responsible for constitutive expression of hZip1 were identified and critical roles for SP1 and CREB1 in transcriptional regulation of the hZip1 gene in prostate cancer cells, was demonstrated. | Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells.
Makhov P, Golovine K, Uzzo RG, Wuestefeld T, Scoll BJ, Kolenko VM., Free PMC Article | 01/21/2010 |
| results show that hZIP1 overexpression has a functional effect on the malignant potential of prostate cancer cells via inhibition of NF-kappaB-dependent pathways and support the concept that hZIP1 may function as a tumor suppressor gene | Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo.
Golovine K, Makhov P, Uzzo RG, Shaw T, Kunkle D, Kolenko VM., Free PMC Article | 01/21/2010 |
| Gene expression regulation of ZIPs after zinc supplementation. | Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
Kahmann L, Uciechowski P, Warmuth S, Plümäkers B, Gressner AM, Malavolta M, Mocchegiani E, Rink L. | 01/21/2010 |
| di-leucine sorting signal of ZIP1 was required and sufficient for endocytosis of the chimeric proteins | A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein.
Huang L, Kirschke CP. | 01/21/2010 |
| down regulation of hZIP1 is a critical early event in the development prostate cancer | hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer.
Franklin RB, Feng P, Milon B, Desouki MM, Singh KK, Kajdacsy-Balla A, Bagasra O, Costello LC., Free PMC Article | 01/21/2010 |
| ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc | Structure, function, and regulation of a subfamily of mouse zinc transporter genes.
Dufner-Beattie J, Langmade SJ, Wang F, Eide D, Andrews GK. | 01/21/2010 |
| zip1 mechanism of transport appears to involve the transport of zinc from low molecular weight ligands that exist in circulation as relatively loosely bound complexes with zinc | Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.
Franklin RB, Ma J, Zou J, Guan Z, Kukoyi BI, Feng P, Costello LC., Free PMC Article | 01/21/2010 |
| In conclusion, these studies provide important insights into the role of a plasma membrane zinc transporter (ZIP1) in the initiation of an osteogenic lineage from MSCs. | Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells.
Tang Z, Sahu SN, Khadeer MA, Bai G, Franklin RB, Gupta A. | 01/21/2010 |