| GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma. | GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma.
Suzuki S, Venkatesh D, Kanda H, Nakayama A, Hosokawa H, Lee E, Miki T, Stockwell BR, Yokote K, Tanaka T, Prives C., Free PMC Article | 10/8/2022 |
| Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma. | Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma.
Wang D, Liu J, Chen Q, Yang R, Jiang Q. | 10/16/2021 |
| Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells. | Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
de Los Santos-Jiménez J, Campos-Sandoval JA, Márquez-Torres C, Urbano-Polo N, Brøndegaard D, Martín-Rufián M, Lobo C, Peñalver A, Gómez-García MC, Martín-Campos J, Cardona C, Castilla L, da Costa Souza F, Cheng T, Segura JA, Alonso FJ, Curi R, Colquhoun A, DeBerardinis RJ, Márquez J, Matés JM., Free PMC Article | 09/4/2021 |
| Structure and activation mechanism of the human liver-type glutaminase GLS2. | Structure and activation mechanism of the human liver-type glutaminase GLS2.
Ferreira IM, Quesñay JEN, Bastos AC, Rodrigues CT, Vollmar M, Krojer T, Strain-Damerell C, Burgess-Brown NA, von Delft F, Yue WW, Dias SM, Ambrosio AL., Free PMC Article | 07/17/2021 |
| Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation. | Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec G, Márquez J., Free PMC Article | 11/21/2020 |
| Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. | Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA., Free PMC Article | 09/19/2020 |
| Study verified that several breast cancer cell lines express endogenous GLS2 and GLS2 expression is linked to enhanced in vitro cell migration and invasion, mesenchymal markers and in vivo lung metastasis. GLS2 amplification or overexpression is linked to worse survival prognosis in breast cancer. Data establish an unforeseen role of GLS2 in sustaining tumor proliferation and underlying metastasis in breast cancer. | GLS2 is protumorigenic in breast cancers.
Dias MM, Adamoski D, Dos Reis LM, Ascenção CFR, de Oliveira KRS, Mafra ACP, da Silva Bastos AC, Quintero M, de G Cassago C, Ferreira IM, Fidelis CHV, Rocco SA, Bajgelman MC, Stine Z, Berindan-Neagoe I, Calin GA, Ambrosio ALB, Dias SMG. | 06/20/2020 |
| Gene-based analysis of the 342 genes in the replication sample using SKAT-O identified one gene, GLS2, significantly associated with complicated Staphylococcus aureus bacteremia(p = 1.2 x 10-4) after Bonferroni correction. The strongest association across all 10,931 variants in the replication sample was with rs2657878 in GLS2 (p = 5 x 10-4). This variant is strongly correlated with a missense variant (rs2657879) | Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia.
Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sørensen E, Hassager C, Bundgaard H, Schønheyder HC, Torp-Pedersen C, Østergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Søgaard P, Andersen PS, Fowler VG Jr., Free PMC Article | 02/16/2019 |
| This study assessed the relation of GLS2 downregulation in glioblastoma cells to its methylation and TP53 status. Aberrant methylation of CpG islands, appear to contribute to silencing of GLS2 in glioblastoma cells by a mechanism bypassing TP53 mutations. | Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status.
Szeliga M, Bogacińska-Karaś M, Kuźmicz K, Rola R, Albrecht J. | 09/9/2017 |
| Non-glutaminolysis function of GLS2 inhibits migration and invasion of hepatocellular carcinoma cells by repressing the epithelial-mesenchymal transition via the Dicer-miR-34a-Snail axis. | Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
Kuo TC, Chen CK, Hua KT, Yu P, Lee WJ, Chen MW, Jeng YM, Chien MH, Kuo KT, Hsiao M, Kuo ML. | 08/12/2017 |
| observe that while miR-23 is capable of down-regulating the shortened KGA 3'UTR, it has only minor impact on the full-length KGA 3'UTR, demonstrating that additional potent negative regulation of GLS expression exists beyond this single microRNA targeting site | CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.
Masamha CP, Xia Z, Peart N, Collum S, Li W, Wagner EJ, Shyu AB., Free PMC Article | 07/15/2017 |
| the crystal structure of full-length KGA and present a small-angle X-ray scattering model for full-length GLS2. These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC. | The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.
Pasquali CC, Islam Z, Adamoski D, Ferreira IM, Righeto RD, Bettini J, Portugal RV, Yue WW, Gonzalez A, Dias SMG, Ambrosio ALB., Free PMC Article | 07/15/2017 |
| Cox multivariate regression analysis demonstrated that DUOX1, GLS2, FBP1 and age were independent risk factors for the prognosis of HCC patients after surgery | The combination of three molecular markers can be a valuable predictive tool for the prognosis of hepatocellular carcinoma patients.
Chen SS, Yu KK, Ling QX, Huang C, Li N, Zheng JM, Bao SX, Cheng Q, Zhu MQ, Chen MQ., Free PMC Article | 04/22/2017 |
| As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1. | Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z., Free PMC Article | 10/22/2016 |
| IDO, through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc, resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA and GLS2 | Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.
Eleftheriadis T, Pissas G, Antoniadi G, Tsogka K, Sounidaki M, Liakopoulos V, Stefanidis I. | 10/8/2016 |
| GABAergic neurons and astrocytes express Gls and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons | Expression of Gls and Gls2 glutaminase isoforms in astrocytes.
Cardona C, Sánchez-Mejías E, Dávila JC, Martín-Rufián M, Campos-Sandoval JA, Vitorica J, Alonso FJ, Matés JM, Segura JA, Norenberg MD, Rama Rao KV, Jayakumar AR, Gutiérrez A, Márquez J. | 09/26/2015 |
| Phosphate-activated glutaminase and GAD65/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls | Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase.
Burbaeva GSh, Boksha IS, Tereshkina EB, Savushkina OK, Prokhorova TA, Vorobyeva EA. | 05/23/2015 |
| GLS2 expression is significantly decreased in hepatocellular carcinoma. | Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
Liu J, Zhang C, Lin M, Zhu W, Liang Y, Hong X, Zhao Y, Young KH, Hu W, Feng Z., Free PMC Article | 02/21/2015 |
| Silencing GLS or overexpressing GLS2 induces growth inhibition in glioma cell lines. | Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián M, Nascimento-Gomes R, Higuero A, Crisma AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Cheng T, Lobo C, Segura JA, Alonso FJ, Szeliga M, Albrecht J, Curi R, Márquez J, Colquhoun A, Deberardinis RJ, Matés JM., Free PMC Article | 10/25/2014 |
| GLS2 is acting, at least in part, downstream of p73 in neuronal differentiation and highlight a possible role of p73 in regulating neurotransmitter synthesis. | GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.
Velletri T, Romeo F, Tucci P, Peschiaroli A, Annicchiarico-Petruzzelli M, Niklison-Chirou MV, Amelio I, Knight RA, Mak TW, Melino G, Agostini M., Free PMC Article | 10/4/2014 |
| combination of negative modulation of glutaminase isoforms arising from GLS gene with the introduction of the GLS2 gene product, GAB, may in the future provide a useful means to curb glioblastoma growth in situ | Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells.
Szeliga M, Bogacińska-Karaś M, Różycka A, Hilgier W, Marquez J, Albrecht J., Free PMC Article | 06/7/2014 |
| Epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers. | Epigenetic silencing of glutaminase 2 in human liver and colon cancers.
Zhang J, Wang C, Chen M, Cao J, Zhong Y, Chen L, Shen HM, Xia D., Free PMC Article | 03/22/2014 |
| The present study was to investigate the potent effect of GLS2 on radioresistance of cervical carcinoma. | Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.
Xiang L, Xie G, Liu C, Zhou J, Chen J, Yu S, Li J, Pang X, Shi H, Liang H. | 03/1/2014 |
| GLS2 is a bona fide TAp63 target gene. | p63 regulates glutaminase 2 expression.
Giacobbe A, Bongiorno-Borbone L, Bernassola F, Terrinoni A, Markert EK, Levine AJ, Feng Z, Agostini M, Zolla L, Agrò AF, Notterman DA, Melino G, Peschiaroli A., Free PMC Article | 12/7/2013 |
| LGA circumvents, by an as yet unknown route, the most common mechanism of O6-methylguanine-DNA methyltransferase (MGMT) gene silencing. | Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents.
Szeliga M, Zgrzywa A, Obara-Michlewska M, Albrecht J. | 12/22/2012 |