| Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion. | Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion.
Li K, Wang A, Diao Y, Fan S. | 06/20/2024 |
| Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis. | Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis.
Du J, Yu L, Yang X, Shao F, Xia J, Jin W, Zhang Y, Lei G, Wang Y, Li Y, Zhang J., Free PMC Article | 02/28/2024 |
| Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4-mediated ferritinophagy. | Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C., Free PMC Article | 01/10/2024 |
| A Novel Role of ARA70 in Regulating Ferritinophagy of RGCs During Retinal Ischemia Reperfusion. | A Novel Role of ARA70 in Regulating Ferritinophagy of RGCs During Retinal Ischemia Reperfusion.
Dong X, Zhang Z, Yu N, Shi H, Lin L, Hou Y. | 12/1/2023 |
| STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. | STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
Jin L, Yu B, Wang H, Shi L, Yang J, Wu L, Gao C, Pan H, Han F, Lin W, Lai EY, Wang YF, Yang Y. | 11/1/2023 |
| ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. | ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Wu H, Liu Q, Shan X, Gao W, Chen Q., Free PMC Article | 06/28/2023 |
| JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. | JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X, Guo F. | 05/23/2023 |
| cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy. | cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B. | 12/10/2022 |
| NCOA4 links iron bioavailability to DNA metabolism. | NCOA4 links iron bioavailability to DNA metabolism.
Federico G, Carrillo F, Dapporto F, Chiariello M, Santoro M, Bellelli R, Carlomagno F. | 08/27/2022 |
| The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. | The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, Wu L, Jiao F, Lin Z, Wu X, Wang X, Zhao Y, Ren J., Free PMC Article | 08/13/2022 |
| Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke. | Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
Li C, Sun G, Chen B, Xu L, Ye Y, He J, Bao Z, Zhao P, Miao Z, Zhao L, Hu J, You Y, Liu N, Chao H, Ji J. | 03/12/2022 |
| Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. | Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease.
Qi X, Song A, Ma M, Wang P, Zhang X, Lu C, Zhang J, Zheng S, Jin H., Free PMC Article | 10/2/2021 |
| NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice. | NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
Nai A, Lidonnici MR, Federico G, Pettinato M, Olivari V, Carrillo F, Geninatti Crich S, Ferrari G, Camaschella C, Silvestri L, Carlomagno F., Free PMC Article | 07/10/2021 |
| NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss. | NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss.
Li X, Lozovatsky L, Sukumaran A, Gonzalez L, Jain A, Liu D, Ayala-Lopez N, Finberg KE., Free PMC Article | 04/13/2021 |
| Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. | Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF., Free PMC Article | 06/9/2018 |
| These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin. | PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.
Ryu MS, Zhang D, Protchenko O, Shakoury-Elizeh M, Philpott CC., Free PMC Article | 09/16/2017 |
| NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo. | NCOA4 Deficiency Impairs Systemic Iron Homeostasis.
Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F. | 10/22/2016 |
| provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo | Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO. | 01/31/2015 |
| NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress. | NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.
Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F. | 10/4/2014 |
| High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer. | Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer.
Wu X, Chen F, Sahin A, Albarracin C, Pei Z, Zou X, Singh B, Xu R, Daniels G, Li Y, Wei J, Blake M, Schneider RJ, Cowin P, Lee P. | 10/29/2011 |
| ARA70alpha functions as a tumor suppressor gene | Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer.
Ligr M, Li Y, Zou X, Daniels G, Melamed J, Peng Y, Wang W, Wang J, Ostrer H, Pagano M, Wang Z, Garabedian MJ, Lee P., Free PMC Article | 01/1/2011 |
| Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor, during development. | Variable expression of nuclear receptor coactivator 4 (NcoA4) during mouse embryonic development.
Kollara A, Brown TJ., Free PMC Article | 07/19/2010 |
| Data suggest that myostatin decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR | Myostatin negatively regulates the expression of the steroid receptor co-factor ARA70.
Siriett V, Nicholas G, Berry C, Watson T, Hennebry A, Thomas M, Ling N, Sharma M, Kambadur R. | 01/21/2010 |