Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk. | Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk. Wu Z, Deng B, Shen Y, Li X, Li J, Li Y, Ma S, Pan Y, Ding F., Free PMC Article | 10/29/2024 |
Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance. | Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance. Cheng X, Jiang W, Chen Y, Zou B, Wang Z, Gan L, Xiao Z, Li C, Yu CY, Lu Y, Han Z, Zeng J, Gu J, Chu T, Fu M, Chu Y, Zhang W, Tang J, Lu M., Free PMC Article | 08/10/2023 |
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice. | Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice. Cheng X, Song X, Li Z, Yuan C, Lei X, Feng M, Hong Z, Zhang L, Hong D. | 10/29/2022 |
HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1alpha-dependent acyloxyacyl hydrolase expression. | HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression. Liu J, Du S, Kong Q, Zhang X, Jiang S, Cao X, Li Y, Li C, Chen H, Ding Z, Liu L., Free PMC Article | 09/25/2021 |
AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study. | AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study. Yang W, Yaggie RE, Schaeffer AJ, Klumpp DJ., Free PMC Article | 10/24/2020 |
AOAH regulates bladder function and the AOAH-Crf axis is a therapeutic target for treating voiding dysfunction. | Acyloxyacyl hydrolase regulates voiding activity. Aguiniga LM, Searl TJ, Rahman-Enyart A, Yaggie RE, Yang W, Schaeffer AJ, Klumpp DJ., Free PMC Article | 07/18/2020 |
By inactivating commensal LPS, AOAH thus prevents desensitization of lung epithelial cells. An enzyme that prevents severe lung inflammation/injury in Gram-negative bacterial pneumonia has the seemingly paradoxical effect of predisposing to a Th2-mediated airway disease. | LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma. Qian G, Jiang W, Zou B, Feng J, Cheng X, Gu J, Chu T, Niu C, He R, Chu Y, Lu M., Free PMC Article | 09/7/2019 |
AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in interstitial cystitis. | Acyloxyacyl hydrolase modulates pelvic pain severity. Yang W, Yaggie RE, Jiang MC, Rudick CN, Done J, Heckman CJ, Rosen JM, Schaeffer AJ, Klumpp DJ., Free PMC Article | 01/19/2019 |
Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia. | Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury. Zou B, Jiang W, Han H, Li J, Mao W, Tang Z, Yang Q, Qian G, Qian J, Zeng W, Gu J, Chu T, Zhu N, Zhang W, Yan D, He R, Chu Y, Lu M., Free PMC Article | 12/23/2017 |
AOAH has a role in modulating microbiota signals that drive Th17 polarization and influence mucosal T-cell immunity | Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Janelsins BM, Lu M, Datta SK., Free PMC Article | 03/15/2014 |
role in clearing and catabolizing both free LPS and the LPS in circulating LPS-lipoprotein complexes | Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes. Shao B, Munford RS, Kitchens R, Varley AW., Free PMC Article | 05/4/2013 |
Recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in in mice that lack AOAH, a lipase that partially deacylates the bacterial cell-wall lipopolysaccharide. | Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection. Lu M, Varley AW, Ohta S, Hardwick J, Munford RS., Free PMC Article | 01/21/2010 |
produced by renal cortical tubule cells and secreted into urine, where it can deacylate lipopolysaccharides, a mechanism to limit inflammatory response to gram-negative bacteria in urinary tract | Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. Feulner JA, Lu M, Shelton JM, Zhang M, Richardson JA, Munford RS., Free PMC Article | 01/21/2010 |