| PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway. | PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.
Ohata H, Shiokawa D, Sakai H, Kanda Y, Okimoto Y, Kaneko S, Hamamoto R, Nakagama H, Okamoto K. | 10/11/2023 |
| Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. | Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis.
Tyagi A, Chandrasekaran B, Navin AK, Shukla V, Baby BV, Ankem MK, Damodaran C. | 03/22/2023 |
| Nrf2 regulates the expression of NOX1 in TNF-alpha-induced A549 cells. | Nrf2 regulates the expression of NOX1 in TNF-α-induced A549 cells.
Wu W, Zhang J, Su X, Lin X, Zhu L, Zhuang Z, Liu C, Zhu Z, Zeng Y. | 01/14/2023 |
| Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients. | Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients.
Hursitoglu O, Kurutas EB, Strawbridge R, Oner E, Gungor M, Tuman TC, Uygur OF. | 12/3/2022 |
| Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation. | Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.
Wei X, Xue M, Kang C, Gao L, Zhang M, Ma C, Jia W, Zheng Y, Cao L, Chen P, Jiang S, Chu FF, Gao Q., Free PMC Article | 08/27/2022 |
| Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells. | Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells.
Wu W, Li L, Su X, Zhu Z, Lin X, Zhang J, Zhuang Z, Cai H, Huang W., Free PMC Article | 10/16/2021 |
| NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma. | NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma.
Vandierendonck A, Degroote H, Vanderborght B, Verhelst X, Geerts A, Devisscher L, Van Vlierberghe H., Free PMC Article | 09/4/2021 |
| ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells. | ABCG1 Attenuates Oxidative Stress Induced by H(2)O(2) through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.
Xue J, Fan J, Li Y, Wu W, Yan Q, Zheng Q., Free PMC Article | 08/28/2021 |
| NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function. | NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function.
Liu J, Iwata K, Zhu K, Matsumoto M, Matsumoto K, Asaoka N, Zhang X, Ibi M, Katsuyama M, Tsutsui M, Kato S, Yabe-Nishimura C. | 06/26/2021 |
| Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma. | Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
Kohsari M, Khadem Ansari MH, Rasmi Y., Free PMC Article | 06/5/2021 |
| Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. | Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study.
Attri P, Park JH, De Backer J, Kim M, Yun JH, Heo Y, Dewilde S, Shiratani M, Choi EH, Lee W, Bogaerts A. | 04/3/2021 |
| Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes. | Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes.
Schiffer TA, Lundberg JO, Weitzberg E, Carlström M. | 01/9/2021 |
| NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression. | NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.
Ohata H, Shiokawa D, Obata Y, Sato A, Sakai H, Fukami M, Hara W, Taniguchi H, Ono M, Nakagama H, Okamoto K. | 08/22/2020 |
| NADPH oxidase 1 is highly expressed in human large and small bowel cancers. | NADPH oxidase 1 is highly expressed in human large and small bowel cancers.
Lu J, Jiang G, Wu Y, Antony S, Meitzler JL, Juhasz A, Liu H, Roy K, Makhlouf H, Chuaqui R, Butcher D, Konaté MM, Doroshow JH., Free PMC Article | 08/13/2020 |
| Ras overactivation switches the pattern of PDIA1-dependent Rac1/Nox1 regulation, so that Ras-induced PDIA1 bypass can directly activate Rac1. PDIA1 may be a crucial regulator of redox-dependent adaptive processes related to cancer progression. | Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.
De Bessa TC, Pagano A, Moretti AIS, Oliveira PVS, Mendonça SA, Kovacic H, Laurindo FRM., Free PMC Article | 06/6/2020 |
| NOX1 and Fibulin-5 were increased and decreased in aortic dissection, respectively. NOX1 is a negative modulator of Fibulin-5. | NOX1 Negatively Modulates Fibulin-5 in Vascular Smooth Muscle Cells to Affect Aortic Dissection.
Hu X, Jiang W, Wang Z, Li L, Hu Z. | 02/1/2020 |
| NOX1 promotes the self-renewal property of CD133 + thyroid cancer cells. | ROS-generating oxidase NOX1 promotes the self-renewal activity of CD133+ thyroid cancer cells through activation of the Akt signaling.
Wang C, Wang Z, Liu W, Ai Z. | 12/14/2019 |
| we identify specific cysteine residues of protein disulfide isomerase and p47phox necessary for the direct interaction of these proteins, the assembly of the Nox1 complex and subsequent activation of Nox1 in vascular disease. | Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47(phox) in Vascular Smooth Muscle Cells.
Gimenez M, Veríssimo-Filho S, Wittig I, Schickling BM, Hahner F, Schürmann C, Netto LES, Rosa JC, Brandes RP, Sartoretto S, De Lucca Camargo L, Abdulkader F, Miller FJ Jr, Lopes LR., Free PMC Article | 12/7/2019 |
| our findings identify a previously uncharacterized mechanism whereby Nox1-induced PKA activity leads to nuclear translocation of CREB, and in association with Ref-1, promotes Gremlin1 transcription. | Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.
de Jesus DS, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, Kaufman BA, Gladwin MT, Pagano PJ., Free PMC Article | 11/30/2019 |
| Upregulated stromal NOX1 expression was correlated with aggressive characteristics such as differentiation degree (P=0.042), venous invasion (P=0.041), resection methods (P=0.002), and a lower survival rate (P=0.025, logrank test) of patients with GBC. | Upregulated NOX1 expression in gallbladder cancer‑associated fibroblasts predicts a poor prognosis.
Wang FT, Hassan M, Ansari KH, Xu GL, Li XP, Fan YZ. | 10/26/2019 |
| Inhibition of NOX2 and NOX1 with siRNA or chemical inhibitors significantly suppresses reactive oxygen species production and DNA damage induced by acidic bile salts. | Activation of NADPH oxidases leads to DNA damage in esophageal cells.
Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI., Free PMC Article | 04/27/2019 |
| this study shows that NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease | NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.
Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ, WGS500 Consortium, Oxford IBD cohort study investigators, COLORS in IBD group investigators, UK IBD Genetics Consortium, Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J, INTERVAL Study, Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH., Free PMC Article | 12/22/2018 |
| depletion of NOX1 and NOX4 partially rescued the growth inhibition of PARP1-deficient tumor xenografts. Our findings suggest that in addition to compromising the repair of DNA damage, PARP inhibition or depletion may exert extra antitumor effect by elevating oxidative stress in ovarian cancer cells | Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.
Hou D, Liu Z, Xu X, Liu Q, Zhang X, Kong B, Wei JJ, Gong Y, Shao C., Free PMC Article | 10/27/2018 |
| NOX activation might have a role in regulation of lymphocytic activity in patients with idiopathic nephrotic syndrome through the impairment of PDGF mitogenic function and might contribute toward pathogenesis of nephrotic syndrome. | NOX-mediated impairment of PDGF-induced DNA synthesis in peripheral blood lymphocytes of children with idiopathic nephrotic syndrome.
Al-Eisa A, Dhaunsi GS. | 07/28/2018 |
| The SUMO1/UBC9 axis may regulate Nox1mediated diabetic retinopathy by inhibiting reactive oxygen species generation and apoptosis. | SUMO1/UBC9‑decreased Nox1 activity inhibits reactive oxygen species generation and apoptosis in diabetic retinopathy.
Hu J, Xue P, Mao X, Xie L, Li G, You Z., Free PMC Article | 07/21/2018 |