| NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice. | NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice.
Liu L, Yang Y, Wu T, Du J, Long F., Free PMC Article | 03/1/2024 |
| NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis. | NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
Marinović S, Lenartić M, Mladenić K, Šestan M, Kavazović I, Benić A, Krapić M, Rindlisbacher L, Cokarić Brdovčak M, Sparano C, Litscher G, Turk Wensveen T, Mikolašević I, Fučkar Čupić D, Bilić-Zulle L, Steinle A, Waisman A, Hayday A, Tugues S, Becher B, Polić B, Wensveen FM., Free PMC Article | 02/15/2024 |
| IL-17a-producing gammadeltaT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia. | IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.
Cui TX, Brady AE, Zhang YJ, Anderson C, Popova AP., Free PMC Article | 09/29/2023 |
| CD8[+] T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. | CD8(+) T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, Khasraw M, Gunn MD, Fecci PE., Free PMC Article | 09/27/2023 |
| TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses. | TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.
Harris R, Mammadli M, Hiner S, Suo L, Yang Q, Sen JM, Karimi M., Free PMC Article | 05/30/2023 |
| Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2. | Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Tsyklauri O, Chadimova T, Niederlova V, Kovarova J, Michalik J, Malatova I, Janusova S, Ivashchenko O, Rossez H, Drobek A, Vecerova H, Galati V, Kovar M, Stepanek O., Free PMC Article | 03/4/2023 |
| Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival. | Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival.
Dastagir N, Beal Z, Godwin J., Free PMC Article | 05/7/2022 |
| Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy. | Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy.
Banerjee A, Li D, Guo Y, Mahgoub B, Paragas L, Slobin J, Mei Z, Manafi A, Hata A, Li K, Shi L, Westwick J, Slingluff C, Lazear E, Krupnick AS., Free PMC Article | 01/8/2022 |
| The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation. | The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.
Lin CM, Gill RG, Mehrad B., Free PMC Article | 11/13/2021 |
| NKG2D Enhances Double-Negative T Cell Regulation of B Cells. | NKG2D Enhances Double-Negative T Cell Regulation of B Cells.
Hu SH, Zhang LH, Gao J, Guo JH, Xun XD, Xiang X, Cheng Q, Li Z, Zhu JY., Free PMC Article | 10/2/2021 |
| NKG2D defines tumor-reacting effector CD8(+) T cells within tumor microenvironment. | NKG2D defines tumor-reacting effector CD8(+) T cells within tumor microenvironment.
Mojic M, Shitaoka K, Ohshima C, Ucche S, Lyu F, Hamana H, Tahara H, Kishi H, Hayakawa Y., Free PMC Article | 09/18/2021 |
| Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. | Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.
Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR., Free PMC Article | 09/11/2021 |
| Deficiency of miR-15a/16 upregulates NKG2D in CD8(+) T cells to exacerbate dextran sulfate sodium-induced colitis. | Deficiency of miR-15a/16 upregulates NKG2D in CD8(+) T cells to exacerbate dextran sulfate sodium-induced colitis.
Jia X, Wei Y, Miao X, Zhu T, Hu X, Lin Z, Xiao W, Zhang Y, Wang Z, Gong W. | 07/17/2021 |
| NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells. | NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.
Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi MF, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers DR, Gagliani N, Huber S, Flavell RA, Polic B, Romagnani C., Free PMC Article | 03/6/2021 |
| Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2. | Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2.
Prinz D, Klein K, List J, Knab VM, Menzl I, Leidenfrost N, Heller G, Polić B, Putz EM, Witalisz-Siepracka A, Sexl V, Gotthardt D., Free PMC Article | 12/12/2020 |
| Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway. | Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway.
Alvarez M, Simonetta F, Baker J, Pierini A, Wenokur AS, Morrison AR, Murphy WJ, Negrin RS., Free PMC Article | 10/24/2020 |
| Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education. | Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education.
Chen S, Dong Z. | 08/15/2020 |
| The NK cell activation receptor, NKG2D, plays a key role in NK cell cytotoxicity of embryonic stem cell-derived hepatocyte-like cells (HLC), but not induced pluripotent stem cell-derived HLC. | Differential role of natural killer group 2D in recognition and cytotoxicity of hepatocyte-like cells derived from embryonic stem cells and induced pluripotent stem cells.
Cisneros T, Dillard DW, Qu X, Arredondo-Guerrero J, Castro M, Schaffert S, Martin R, Esquivel CO, Krams SM, Martinez OM., Free PMC Article | 07/18/2020 |
| The interaction between immune cells and cardiomyocytes via NKG2D/NKG2DL induces cardiomyocyte death, exacerbating cardiac remodelling after myocardial infarction. | Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction.
Matsumoto K, Obana M, Kobayashi A, Kihara M, Shioi G, Miyagawa S, Maeda M, Sakata Y, Nakayama H, Sawa Y, Fujio Y. | 05/9/2020 |
| Signaling through NKG2D during the effector phase (certification) favors the development of functional memory CD8 T cells, a previously undescribed role for NKG2D. | NKG2D signaling certifies effector CD8 T cells for memory formation.
Perez C, Prajapati K, Burke B, Plaza-Rojas L, Zeleznik-Le NJ, Guevara-Patino JA., Free PMC Article | 04/4/2020 |
| Our data support the notion that endogenous CD8 T cells contribute to passive EAE pathobiology in a NKG2D-dependent manner. Collectively, our results point to the deleterious role of NKG2D and its MULT1 in the pathobiology of a MS mouse model. | NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.
Legroux L, Moratalla AC, Laurent C, Deblois G, Verstraeten SL, Arbour N., Free PMC Article | 01/11/2020 |
| Studied role of killer cell lectin-like receptor subfamily K member 1 (NKG2D) in immune response of Respiratory Syncytial Virus Infection in wild-type and knockout mice. | NKG2D Regulation of Lung Pathology and Dendritic Cell Function Following Respiratory Syncytial Virus Infection.
Liu H, Osterburg AR, Flury J, Huang S, McCormack FX, Cormier SA, Borchers MT., Free PMC Article | 09/21/2019 |
| Iqgap1(-/-) NK cells failed to fully induce S6 phosphorylation and showed significantly reduced protein translation following NKG2D-mediated activation, revealing a previously undefined regulatory function of IQGAP1 via the mechanistic target of rapamycin complex 1. | IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.
Abel AM, Tiwari AA, Gerbec ZJ, Siebert JR, Yang C, Schloemer NJ, Dixon KJ, Thakar MS, Malarkannan S., Free PMC Article | 08/17/2019 |
| NKG2D is an essential receptor required for the activation of iNKT cells in Con A-induced hepatitis | Critical Contribution of NK Group 2 Member D Expressed on Invariant Natural Killer T Cells in Concanavalin A-Induced Liver Hepatitis in Mice.
Al Dulaimi D, Klibi J, Olivo Pimentel V, Parietti V, Allez M, Toubert A, Benlagha K., Free PMC Article | 07/13/2019 |
| Data show that indoleamine 2,3 dioxygenase-1 (IDO1)/ miR-18a/ killer cell lectin-like receptor subfamily K (NKG2D/NKG2DL) regulatory axis in the regulation of NK cell function. | IDO1 impairs NK cell cytotoxicity by decreasing NKG2D/NKG2DLs via promoting miR-18a.
Zhang J, Han X, Hu X, Jin F, Gao Z, Yin L, Qin J, Yin F, Li C, Wang Y. | 05/4/2019 |