| Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation. | Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Miao Y, Liu J. | 01/30/2024 |
| Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. | Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization.
Kabirova M, Reichenstein M, Borovok N, Sheinin A, Gorobets D, Michaelevski I. | 07/13/2023 |
| Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2. | Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2.
Fu D, Liu B, Jiang H, Li Z, Fan C, Zang L. | 04/9/2022 |
| CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis. | CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.
Xu J, Hao Y, Gao X, Wu Y, Ding Y, Wang B., Free PMC Article | 02/26/2022 |
| Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation. | Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
Amado-Azevedo J, van Stalborch AD, Valent ET, Nawaz K, van Bezu J, Eringa EC, Hoevenaars FPM, De Cuyper IM, Hordijk PL, van Hinsbergh VWM, van Nieuw Amerongen GP, Aman J, Margadant C., Free PMC Article | 01/15/2022 |
| microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2. | microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2.
Zhang G, Xia M, Guo J, Huang Y, Huang J, Wei K, Zhang X, Zeng J, Liang W., Free PMC Article | 11/27/2021 |
| miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2. | miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
Xu B, Wang C, Wang YL, Chen SQ, Wu JP, Zhu WD, Wang CY, Guan H, Guan C, You ZH, Chen M. | 10/9/2021 |
| Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. | Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.
Wu K, Wu H, Lyu W, Kim Y, Furdui CM, Anderson KS, Koleske AJ., Free PMC Article | 08/28/2021 |
| The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis. | The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
Hoj JP, Mayro B, Pendergast AM., Free PMC Article | 02/13/2021 |
| Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells. | Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells.
Chen L, Zhu M, Yu S, Hai L, Zhang L, Zhang C, Zhao P, Zhou H, Wang S, Yang X. | 11/21/2020 |
| Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling. | Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling.
Tripathi R, Liu Z, Jain A, Lyon A, Meeks C, Richards D, Liu J, He D, Wang C, Nespi M, Rymar A, Wang P, Wilson M, Plattner R., Free PMC Article | 11/21/2020 |
| Epidermal Growth Factor Receptor and Abl2 Kinase Regulate Distinct Steps of Human Papillomavirus 16 Endocytosis. | Epidermal Growth Factor Receptor and Abl2 Kinase Regulate Distinct Steps of Human Papillomavirus 16 Endocytosis.
Bannach C, Brinkert P, Kühling L, Greune L, Schmidt MA, Schelhaas M., Free PMC Article | 10/24/2020 |
| High expression of ABL2 suppresses apoptosis in gastric cancer cell lines | High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer.
Liu Y, Shao C, Zhu L, Jiang S, Li G, Zhang W, Lin Y, Ni Y, Cao H, Shao S. | 06/8/2019 |
| c-Abl/Arg are oncogenic kinases that regulate differential gene expression | Global Regulation of Differential Gene Expression by c-Abl/Arg Oncogenic Kinases.
Dong Q, Li C, Qu X, Cao C, Liu X., Free PMC Article | 03/31/2018 |
| Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration | Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.
Aras S, Arrabi H, Purandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI. | 06/24/2017 |
| the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. | ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via signal transducer and activator of transcription 5 activation in the acute promyelocytic leukemia cell line HT93A.
Iriyama N, Hatta Y, Takei M. | 04/9/2016 |
| Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. | Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.
Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ., Free PMC Article | 06/6/2015 |
| Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. | miR-20a promotes prostate cancer invasion and migration through targeting ABL2.
Qiang XF, Zhang ZW, Liu Q, Sun N, Pan LL, Shen J, Li T, Yun C, Li H, Shi LH. | 01/17/2015 |
| Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. | c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.
Fiore LS, Ganguly SS, Sledziona J, Cibull ML, Wang C, Richards DL, Neltner JM, Beach C, McCorkle JR, Kaetzel DM, Plattner R., Free PMC Article | 11/8/2014 |
| data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication | Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK.
Hutterer C, Wandinger SK, Wagner S, Müller R, Stamminger T, Zeitträger I, Godl K, Baumgartner R, Strobl S, Marschall M. | 01/4/2014 |
| Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. | β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.
Beaty BT, Sharma VP, Bravo-Cordero JJ, Simpson MA, Eddy RJ, Koleske AJ, Condeelis J., Free PMC Article | 12/21/2013 |
| Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). | Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.
Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ., Free PMC Article | 08/10/2013 |
| Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. | Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection.
Bianco MV, Blanco FC, Forrellad MA, Aguilar D, Campos E, Klepp LI, Hernández-Pando R, Cataldi AA, Bigi F. | 08/20/2012 |
| c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo | c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.
Ganguly SS, Fiore LS, Sims JT, Friend JW, Srinivasan D, Thacker MA, Cibull ML, Wang C, Novak M, Kaetzel DM, Plattner R., Free PMC Article | 08/18/2012 |
| Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion | An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.
Mader CC, Oser M, Magalhaes MA, Bravo-Cordero JJ, Condeelis J, Koleske AJ, Gil-Henn H., Free PMC Article | 04/23/2011 |