| Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer. | Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer.
Zhou Y, Zhang T, Wang S, Yang R, Jiao Z, Lu K, Li H, Jiang W, Zhang X. | 08/25/2023 |
| UHRF1 regulates the transcriptional repressor HBP1 through MIF in T acute lymphoblastic leukemia. | UHRF1 regulates the transcriptional repressor HBP1 through MIF in T acute lymphoblastic leukemia.
Yao J, Luo Y, Zeng C, He H, Zhang X. | 12/4/2021 |
| miR-146b Functions as an Oncogene in Oral Squamous Cell Carcinoma by Targeting HBP1. | miR-146b Functions as an Oncogene in Oral Squamous Cell Carcinoma by Targeting HBP1.
Li K, Zhou Z, Li J, Xiang R., Free PMC Article | 11/6/2021 |
| Regulatory role of transcription factor HBP1 in anticancer efficacy of EGFR inhibitor erlotinib in HNSCC. | Regulatory role of transcription factor HBP1 in anticancer efficacy of EGFR inhibitor erlotinib in HNSCC.
Chan CY, Chang CM, Chen YH, Sheu JJ, Lin TY, Huang CY. | 08/14/2021 |
| HBP1 deficiency protects against stress-induced premature senescence of nucleus pulposus. | HBP1 deficiency protects against stress-induced premature senescence of nucleus pulposus.
Liu W, Li WC, Pan XF, Sha H, Gong WQ, Yan M. | 05/15/2021 |
| Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence. | Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.
Yao ZZ, Tan HC, Chen JF, Jin T, Zhou CS, Liang J, Hu AX. | 11/21/2020 |
| Reduced HBP1 expression and subsequent MMP-13 upregulation may play a pivotal role in the invasiveness of oral cancer. | Matrix metalloproteinase-13 is a target gene of high-mobility group box-containing protein 1 in modulating oral cancer cell invasion.
Chan CY, Lin TY, Sheu JJ, Wu WC, Huang CY. | 03/21/2020 |
| MDM2 facilitates HBP1 proteasomal degradation by ubiquitinating HBP1, regardless of p53 status, thus attenuating the transcriptional inhibition of HBP1 in the expression of its target genes, such as the DNA methyltransferase DNMT1 and histone methyltransferase EZH2, which results in global DNA hypermethylation and histone hypermethylation and ultimately genome instability. | MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, Jiang W, Li G, Gui Y, Zhang X., Free PMC Article | 12/14/2019 |
| Our experiment also verified the target relationship between miR-21 and HBP1. MiR-21 may affect migration and invasion ability of drug-resistant lung adenocarcinoma cells by targeting HBP1, therefore modulating EMT. | MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1.
Su C, Cheng X, Li Y, Han Y, Song X, Yu D, Cao X, Liu Z., Free PMC Article | 11/2/2019 |
| HBP1 functions as a tumor suppressor, and its ectopic expression hindered cell proliferation of non-small-cell lung cancer (NSCLC). AFAP1-AS1 repressed HBP1 expression by recruiting LSD1 to the HBP1 promoter regions in NSCLC cell lines. | Long noncoding RNA actin filament-associated protein 1 antisense RNA 1 promotes malignant phenotype through binding with lysine-specific demethylase 1 and repressing HMG box-containing protein 1 in non-small-cell lung cancer.
Yu S, Yang D, Ye Y, Liu P, Chen Z, Lei T, Pu J, Liu L, Wang Z., Free PMC Article | 07/20/2019 |
| results suggest that HBP1 phosphorylation by AKT blocks its functions as transcriptional regulator and tumor suppressor. | HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation.
Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle VA, Havelange V, Rider MH, Vertommen D, Demoulin JB. | 06/29/2019 |
| HBP1 functions as a non-tumor suppressor gene in nasopharyngeal carcinoma. | HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma.
He S, Yang S, Niu M, Zhong Y, Dan Gao, Zhang Y, Ma H, Xiong W, Zhou M, Zhou Y, Xiang B, Li G, Shuai C, Peng S., Free PMC Article | 06/15/2019 |
| Mutant ALK downregulates the 'HMG-box transcription factor 1' (HBP1). | ALK positively regulates MYCN activity through repression of HBP1 expression.
Claeys S, Denecker G, Durinck K, Decaesteker B, Mus LM, Loontiens S, Vanhauwaert S, Althoff K, Wigerup C, Bexell D, Dolman E, Henrich KO, Wehrmann L, Westerhout EM, Demoulin JB, Kumps C, Van Maerken T, Laureys G, Van Neste C, De Wilde B, De Wever O, Westermann F, Versteeg R, Molenaar JJ, Påhlman S, Schulte JH, De Preter K, Speleman F. | 05/4/2019 |
| this review discusses our current understanding of HBP1 function in human physiology and diseases. [Review] | The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.
Bollaert E, de Rocca Serra A, Demoulin JB., Free PMC Article | 04/27/2019 |
| Data show that the GID/CTLH E3 ubiquitin ligase prevents cell cycle exit in G1, at least in part by degrading HMG-box transcription factor 1 protein (Hbp1). | The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.
Lampert F, Stafa D, Goga A, Soste MV, Gilberto S, Olieric N, Picotti P, Stoffel M, Peter M., Free PMC Article | 04/27/2019 |
| Study shows that RORbeta is a transcriptional enhancer of inhibitor HBP1 of the Wnt pathway. NRIP2 prevents RORbeta to bind with downstream HBP1 promoter regions and reduces the transcription of HBP1. These results provide evidence that interactions between NRIP2, RORbeta, and HBP1 mediate a new mechanism for CCIC self-renewal via the Wnt activity. | Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ.
Wen Z, Pan T, Yang S, Liu J, Tao H, Zhao Y, Xu D, Shao W, Wu J, Liu X, Wang Y, Mao J, Zhu Y., Free PMC Article | 02/10/2018 |
| Low HBP1 expression is associated with invasive oral cancer. | Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer.
Chan CY, Huang SY, Sheu JJ, Roth MM, Chou IT, Lien CH, Lee MF, Huang CY., Free PMC Article | 10/14/2017 |
| induced premature senescence and apoptosis. Furthermore, the Pim-1-HBP1 positive feedback loop exerts its effect by regulating the senescence markers DNMT1 and p16 and the apoptosis marker Bax. The Pim-1-HBP1 axis thus constitutes a novel checkpoint pathway critical for the inhibition of tumorigenesis. | A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, Li G, Zhang X., Free PMC Article | 06/10/2017 |
| Data suggest HMG-box transcription factor (HBP1) as a target in prostate cancer radiotherapy. | Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines.
Chen Y, Wang Y, Yu Y, Xu L, Zhang Y, Yu S, Li G, Zhang Z., Free PMC Article | 12/17/2016 |
| Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. | HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X., Free PMC Article | 12/17/2016 |
| All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. | All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/β-Catenin Signaling in Human Colorectal Cancer Cells.
Lee MF, Hsieh NT, Huang CY, Li CI. | 09/3/2016 |
| HBP1-mediated Wnt signaling is involved with the role of miR-155 in osteosarcoma progression. | miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism.
Sun X, Geng X, Zhang J, Zhao H, Liu Y. | 12/26/2015 |
| Hbp1 plays a crucial role in regulating the timing of cortical neurogenesis by elongating the cell cycle and that it is essential for normal cortical development. | Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.
Watanabe N, Kageyama R, Ohtsuka T. | 09/26/2015 |
| HBP1 is a suppressor of cancer progression and a regulator of CTNNB1 gene transcription. | HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC.
Tseng RC, Huang WR, Lin SF, Wu PC, Hsu HS, Wang YC., Free PMC Article | 04/18/2015 |
| HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response to growth factors. | The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.
Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos KE, Burgering BM, Coffer PJ, Essaghir A, Demoulin JB. | 06/21/2014 |