| The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis. | The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
Lu Y, Fan D, Wang W, Gao X, Li H, Guo S, Zhao L, Guo Y, Li B, Zhong Y, Zhang B, Liu J, Dai L, Kang Q, Ji Z. | 12/11/2021 |
| Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation. | Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.
Huang SC, Vu LV, Yu FH, Nguyen DT, Benz EJ Jr., Free PMC Article | 12/11/2021 |
| Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid. | Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.
Li B, Zhang X, Lu Y, Zhao L, Guo Y, Guo S, Kang Q, Liu J, Dai L, Zhang L, Fan D, Ji Z. | 06/12/2021 |
| Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-kappaB pathway. | Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.
Liang T, Guo Y, Li M, Ding C, Sang S, Zhou T, Shao Q, Liu X, Lu J, Ji Z, Wang T, Kang Q., Free PMC Article | 05/29/2021 |
| Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction. | Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.
Ding C, Guo Y, Liang T, Liu J, Yang L, Wang T, Liu X, Kang Q. | 05/1/2021 |
| Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells. | Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
Zhao Q, Li Y, Li Y, Ji X, Li H, Wu D, Wei W, Xinchun W., Free PMC Article | 01/9/2021 |
| Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcepsilonRI Signaling and Chemotaxis in Mast Cells. | Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.
Draberova L, Draberova H, Potuckova L, Halova I, Bambouskova M, Mohandas N, Draber P., Free PMC Article | 11/21/2020 |
| The role of 4.1R in the regulation of EGFR signaling in keratinocytes. | Cytoskeleton protein 4.1R suppresses murine keratinocyte cell hyperproliferation via activating the Akt/ERK pathway in an EGFR-dependent manner.
Chen L, Wang T, Ji X, Ding C, Liang T, Liu X, Lu J, Guo X, Kang Q, Ji Z. | 06/20/2020 |
| These data enabled the identification of a negative regulation function for 4.1R in CD8(+) T cells by a direct association between 4.1R and LAT, possibly through inhibiting phosphorylation of LAT and then modulating intracellular signal transduction. | Protein 4.1R negatively regulates CD8(+) T-cell activation by modulating phosphorylation of linker for activation of T cells.
Fan D, Li J, Li Y, Guo Y, Zhang X, Wang W, Liu X, Liu J, Dai L, Zhang L, Kang Q, Ji Z., Free PMC Article | 12/7/2019 |
| Formation of an erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mammals. | Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.
Huang YS, Delgadillo LF, Cyr KH, Kingsley PD, An X, McGrath KE, Mohandas N, Conboy JG, Waugh RE, Wan J, Palis J., Free PMC Article | 01/12/2019 |
| 4.1R plays an important role in transporting 5-aminolevulinic acid into cells via at least partly interaction with GAT1 and GAT2 transporters in 5-ALA-PDT. | Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells.
Ning S, Kang Q, Fan D, Liu J, Xue C, Zhang X, Ding C, Zhang J, Peng Q, Ji Z. | 12/22/2018 |
| This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradation. | Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation.
Huang SC, Zhou A, Nguyen DT, Zhang HS, Benz EJ Jr., Free PMC Article | 05/27/2017 |
| The proportion of 4.1R-positive cells was significantly higher in the HF group than in the controls, which was confirmed by the positive mRNA expression of 4.1R. 4.1R localized mostly to the plasma membrane of myocardial cells and was upregulated with the progression of HF. This suggests that 4.1R may be associated with HF progression. | Correlation between protein 4.1R and the progression of heart failure in vivo.
Wei Z, Yang G, Xu R, Zhu C, He F, Dou Q, Tang J. | 03/18/2017 |
| suggest that 4.1R can prevent pathogenic autoimmunity in MS/EAE progression by suppressing the CD4(+) T cell activation | Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4(+) T cell activation.
Liu X, Zhou Q, Ji Z, Fu G, Li Y, Zhang X, Shi X, Wang T, Kang Q. | 02/21/2015 |
| Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 causes increase in cortical NuMA localization | NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.
Seldin L, Poulson ND, Foote HP, Lechler T., Free PMC Article | 06/28/2014 |
| a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b. | Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b).
Liu C, Weng H, Chen L, Yang S, Wang H, Debnath G, Guo X, Wu L, Mohandas N, An X., Free PMC Article | 06/15/2013 |
| At the intercalated disc 4.1R does not colocalise with the adherens junction protein, beta-catenin, but does overlap with the other plasma membrane signalling proteins, the Na/K-ATPase and the Na/Ca exchanger NCX1. | Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.
Pinder JC, Taylor-Harris PM, Bennett PM, Carter E, Hayes NV, King MD, Holt MR, Maggs AM, Gascard P, Baines AJ. | 08/25/2012 |
| Cell adhesion and signaling pathways regulated by alphavbeta8 integrin and Band 4.1B are essential for normal formation and function of the heart during embryogenesis. | β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.
Jung Y, Kissil JL, McCarty JH. | 05/14/2011 |
| 4.1R gene expression involves transcriptional regulation coupled with a complex splicing regulatory network. | Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene.
Huang SC, Cho A, Norton S, Liu ES, Park J, Zhou A, Munagala ID, Ou AC, Yang G, Wickrema A, Tang TK, Benz EJ Jr., Free PMC Article | 01/21/2010 |
| 4.1R knockout mice exhibit bradycardia, prolonged action potentials & QT intervals, and anomalous ion channel activities. 4.1R has a role in the cellular accumulation of NaV1.5. Review. | Protein 4.1 and the control of ion channels.
Baines AJ, Bennett PM, Carter EW, Terracciano C. | 01/21/2010 |
| Silencing of histone acetyltransferase Elongator complex scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. | Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.
Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L. | 01/21/2010 |
| Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart. | Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart.
Stagg MA, Carter E, Sohrabi N, Siedlecka U, Soppa GK, Mead F, Mohandas N, Taylor-Harris P, Baines A, Bennett P, Yacoub MH, Pinder JC, Terracciano CM. | 01/21/2010 |
| 4.1R organizes a macromolecular complex of skeletal and transmembrane proteins at the junctional node. | Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.
Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X., Free PMC Article | 01/21/2010 |
| These results suggest that erythroid protein 4.1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes. | Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes.
Rivera A, De Franceschi L, Peters LL, Gascard P, Mohandas N, Brugnara C. | 01/21/2010 |
| We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1R is likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies.[Epb41] | Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.
Taylor-Harris PM, Keating LA, Maggs AM, Phillips GW, Birks EJ, Franklin RC, Yacoub MH, Baines AJ, Pinder JC. | 01/21/2010 |