| Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. | Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.
Malavazos AE, Iacobellis G, Dozio E, Basilico S, Di Vincenzo A, Dubini C, Menicanti L, Vianello E, Meregalli C, Ruocco C, Ragni M, Secchi F, Spagnolo P, Castelvecchio S, Morricone L, Buscemi S, Giordano A, Goldberger JJ, Carruba M, Cinti S, Corsi Romanelli MM, Nisoli E. | 06/13/2023 |
| Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation. | Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation.
Alsalim W, Lindgren O, Ahrén B., Free PMC Article | 02/27/2023 |
| GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes. | GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes.
Heimbürger SMN, Hoe B, Nielsen CN, Bergman NC, Skov-Jeppesen K, Hartmann B, Holst JJ, Dela F, Overgaard J, Størling J, Vilsbøll T, Dejgaard TF, Havelund JF, Gorshkov V, Kjeldsen F, Færgeman NJ, Madsen MR, Christensen MB, Knop FK. | 12/3/2022 |
| The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection. | The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection.
Lindquist P, Gasbjerg LS, Mokrosinski J, Holst JJ, Hauser AS, Rosenkilde MM., Free PMC Article | 07/23/2022 |
| Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis. | Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis.
Grespan E, Guolo A, Muscelli E, Ferrannini E, Mari A. | 06/25/2022 |
| The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury. | The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury.
Kahles F, Rau M, Reugels M, Foldenauer AC, Mertens RW, Arrivas MC, Schröder J, Idel P, Moellmann J, van der Vorst EPC, Marx N, Lehrke M., Free PMC Article | 03/5/2022 |
| The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update. | The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update.
Nauck MA, Quast DR, Wefers J, Pfeiffer AFH. | 10/23/2021 |
| Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis. | Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis.
Zeng L, Xi F, Yang Y, Guo L, Hu H, Yang Q, Ma Q. | 09/4/2021 |
| GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex. | GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex.
Ke R, Lok SIS, Singh K, Chow BKC, Lee LTO. | 08/28/2021 |
| Effects of endogenous GIP in patients with type 2 diabetes. | Effects of endogenous GIP in patients with type 2 diabetes.
Stensen S, Gasbjerg LS, Krogh LL, Skov-Jeppesen K, Sparre-Ulrich AH, Jensen MH, Dela F, Hartmann B, Vilsbøll T, Holst JJ, Rosenkilde MM, Christensen MB, Knop FK. | 06/5/2021 |
| The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes. | The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes.
Regazzo D, Barbot M, Scaroni C, Albiger N, Occhi G. | 02/20/2021 |
| Serum Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) in association with the Risk of Gestational Diabetes: A Prospective Case-Control Study. | Serum Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) in association with the Risk of Gestational Diabetes: A Prospective Case-Control Study.
Mosavat M, Omar SZ, Jamalpour S, Tan PC., Free PMC Article | 12/19/2020 |
| GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review. | GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review.
Mori Y, Matsui T, Hirano T, Yamagishi SI., Free PMC Article | 12/5/2020 |
| Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and beta-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly. | Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly.
Shekhawat VS, Bhansali S, Dutta P, Mukherjee KK, Vaiphei K, Kochhar R, Sinha SK, Sachdeva N, Kurpad AV, Bhat K, Mudaliar S, Bhansali A., Free PMC Article | 10/31/2020 |
| Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes. | Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.
Ejarque M, Guerrero-Pérez F, de la Morena N, Casajoana A, Virgili N, López-Urdiales R, Maymó-Masip E, Pujol Gebelli J, Garcia Ruiz de Gordejuela A, Perez-Maraver M, Pellitero S, Fernández-Veledo S, Vendrell J, Vilarrasa N., Free PMC Article | 10/10/2020 |
| his paper describes the early history of Gastric Inhibitory Polypeptide, better referred to simply as GIP, from its isolation by purification from a crude preparation of CCK-PZ (cholecystokinin/pancreozymin) to its recognition as a key player in the pathogenesis of obesity and other metabolic disorders far removed from the enterogastrone properties by which it was originally identified. | The early history of GIP 1969-2000: From enterogastrone to major metabolic hormone.
Marks V. | 07/4/2020 |
| High GIP serum levels are associated with the risk of clear cell renal cell carcinoma. | Circulating obesity-driven biomarkers are associated with risk of clear cell renal cell carcinoma: a two-stage, case-control study.
Wang Q, Tu H, Zhu M, Liang D, Ye Y, Chang DW, Long Y, Wu X., Free PMC Article | 05/30/2020 |
| CART expression was found in glucose-dependent insulinotropic polypeptide (GIP)-producing K-cells and glucagon-like peptide-1 (GLP-1)-producing L-cells in human duodenum and jejunum. | Intestinal CART is a regulator of GIP and GLP-1 secretion and expression.
Shcherbina L, Lindqvist A, Thorén Fischer AH, Ahlqvist E, Zhang E, Falkmer SE, Renström E, Koffert J, Honka H, Wierup N. | 05/4/2019 |
| Study shows that there is sufficient evidence to confirm that gastric inhibitory polypeptide is an obesity-promoting factor in high fat diet conditions and that deletion of gastric inhibitory polypeptide receptor signaling causes resistance to diet-induced obesity. | Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide signaling in adipose tissue.
Yamane S, Harada N., Free PMC Article | 02/16/2019 |
| The genetic variability of GIP gene is associated with coronary artery disease and it may play a role in the premature coronary artery disease in the Chinese Han population with type 2 diabetes. | Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes.
Ma X, Huang J, Lu D, Gu N, Lu R, Zhang J, Zhang H, Li J, Zhang J, Guo X., Free PMC Article | 10/13/2018 |
| Describe model, in which the release of GIP/GLP-1 is stimulated by glucose in the proximal small intestine, and no differences in the secretion dynamics between healthy individuals and patients with T2D are identified after taking differences in glucose profiles into account. | Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose.
Røge RM, Bagger JI, Alskär O, Kristensen NR, Klim S, Holst JJ, Ingwersen SH, Karlsson MO, Knop FK, Vilsbøll T, Kjellsson MC. | 02/3/2018 |
| The ability of a truncated form of GIP, GIP(3-30)NH2, to antagonize the physiological actions of GIP in glucose metabolism, subcutaneous abdominal adipose tissue blood flow, and lipid metabolism in humans. | The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.
Asmar M, Asmar A, Simonsen L, Gasbjerg LS, Sparre-Ulrich AH, Rosenkilde MM, Hartmann B, Dela F, Holst JJ, Bülow J. | 10/21/2017 |
| Compared with the lean group, the obese group had significantly higher fasting and post-OGTT GIP levels, but similar fasting GLP-1 and significantly lower post-OGTT GLP-1 levels. | Incretin secretion in humans is under the influence of cannabinoid receptors.
Chia CW, Carlson OD, Liu DD, González-Mariscal I, Santa-Cruz Calvo S, Egan JM., Free PMC Article | 10/14/2017 |
| GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. | Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.
Škrha J, Bušek P, Uhrová J, Hrabal P, Kmochová K, Laclav M, Bunganič B, Frič P. | 08/12/2017 |
| Evening postprandial insulin and GIP responses and insulin resistance declined by over 30% after three meals that limited daily carbohydrate intake to 30% compared to no such changes after three 60%-carbohydrate meals, an effect that was independent of pre-meal exercise. | Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance.
Lin PJ, Borer KT., Free PMC Article | 07/6/2017 |