| RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells. | RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Zhou W, Zhao S, Xu S, Sun Z, Liang Y, Ding X. | 01/23/2021 |
| Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse. | Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
Lorès P, Vernet N, Kurosaki T, Van de Putte T, Huylebroeck D, Hikida M, Gacon G, Touré A. | 03/29/2014 |
| APC(CDH1) targets MgcRacGAP for destruction in the late M phase. | APC(CDH1) targets MgcRacGAP for destruction in the late M phase.
Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T., Free PMC Article | 12/28/2013 |
| TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases. | TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases.
Barrio L, Saez de Guinoa J, Carrasco YR. | 11/30/2013 |
| several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities | Cooperative activation of PI3K by Ras and Rho family small GTPases.
Yang HW, Shin MG, Lee S, Kim JR, Park WS, Cho KH, Meyer T, Heo WD., Free PMC Article | 10/13/2012 |
| This study demonstrated that loss of Rac1 attenuates synapse structure and function in vivo, which ultimately leads to significant defects in spatial learning and working/episodic-like memory. | A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory.
Haditsch U, Leone DP, Farinelli M, Chrostek-Grashoff A, Brakebusch C, Mansuy IM, McConnell SK, Palmer TD., Free PMC Article | 01/21/2010 |
| mgcRacGAP is now shown to play a indispensable role in the development of hematopoietic cells in vivo. | Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells.
Yamada T, Kurosaki T, Hikida M. | 01/21/2010 |
| Rac became activated within 2 min after peripheral membrane extensions adhered to new ECM islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island | Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation.
Xia N, Thodeti CK, Hunt TP, Xu Q, Ho M, Whitesides GM, Westervelt R, Ingber DE. | 01/21/2010 |
| alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase-Cdc42/Rac pathways may play a role in determining the size and shape of tooth germ | Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.
Fukumoto S, Miner JH, Ida H, Fukumoto E, Yuasa K, Miyazaki H, Hoffman MP, Yamada Y. | 01/21/2010 |
| These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases. | Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation.
Kitamura T, Kawashima T, Minoshima Y, Tonozuka Y, Hirose K, Nosaka T. | 01/21/2010 |
| Gab2 via Shp-2 is critical for transmitting signals from Kit Tyr(567) to activate the Rac/JNK pathway controlling mast cell proliferation | The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H. | 01/21/2010 |
| Rac regulates vascular endothelial growth factor stimulated motility | Rac regulates vascular endothelial growth factor stimulated motility.
Soga N, Connolly JO, Chellaiah M, Kawamura J, Hruska KA. | 01/21/2010 |
| Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP. | Regulation of cytokinesis by mgcRacGAP in B lymphocytes is independent of GAP activity.
Yamada T, Hikida M, Kurosaki T. | 01/21/2010 |