| Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment. | Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment.
Ghosh A, Malavasi EL, Sherman DL, Brophy PJ., Free PMC Article | 03/6/2021 |
| Conditional deletion of the glial isoform Nfasc155 in mice causes severe motor coordination defects and death at 16-17 days after birth. | Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia.
Smigiel R, Sherman DL, Rydzanicz M, Walczak A, Mikolajkow D, Krolak-Olejnik B, Kosinska J, Gasperowicz P, Biernacka A, Stawinski P, Marciniak M, Andrzejewski W, Boczar M, Krajewski P, Sasiadek MM, Brophy PJ, Ploski R., Free PMC Article | 04/27/2019 |
| Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan. | Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.
Taylor AM, Shi Q, Bhat MA., Free PMC Article | 01/26/2019 |
| we identify QKI as the long-sought regulator of Neurofascin alternative splicing | Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.
Darbelli L, Vogel G, Almazan G, Richard S., Free PMC Article | 08/20/2016 |
| P0/NFasc Interaction critical for the integrity of paranodal/nodal structures, but not for the stability of myelin | HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.
Brügger V, Engler S, Pereira JA, Ruff S, Horn M, Welzl H, Münger E, Vaquié A, Sidiropoulos PN, Egger B, Yotovski P, Filgueira L, Somandin C, Lühmann TC, D'Antonio M, Yamaguchi T, Matthias P, Suter U, Jacob C., Free PMC Article | 04/23/2016 |
| Neurofascin 140 is essential for assembly of the node of Ranvier in embryogenesis. | Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.
Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, Li Q, Sherman DL, Reynolds R, Brophy PJ., Free PMC Article | 04/18/2015 |
| In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon. | In vivo assembly of the axon initial segment in motor neurons.
Le Bras B, Fréal A, Czarnecki A, Legendre P, Bullier E, Komada M, Brophy PJ, Davenne M, Couraud F., Free PMC Article | 02/28/2015 |
| loss of Nfasc155 was sufficient to cause a robust delay in postnatal synapse elimination at the NMJ across all muscle groups examined. | Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction.
Roche SL, Sherman DL, Dissanayake K, Soucy G, Desmazieres A, Lamont DJ, Peles E, Julien JP, Wishart TM, Ribchester RR, Brophy PJ, Gillingwater TH., Free PMC Article | 11/22/2014 |
| the apparent dependency on sulfatide for maintaining Nfasc155 and MAG associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis | Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide.
Pomicter AD, Deloyht JM, Hackett AR, Purdie N, Sato-Bigbee C, Henderson SC, Dupree JL., Free PMC Article | 07/26/2014 |
| Neurofascin is O-mannosylated and the glycosylation sites have been mapped. | Neurofascin 186 is O-mannosylated within and outside of the mucin domain.
Pacharra S, Hanisch FG, Breloy I. | 12/8/2012 |
| We propose that neurofascin optimizes communication between mature neurons by anchoring the key elements of the adult axon initial segment complex. | A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment.
Zonta B, Desmazieres A, Rinaldi A, Tait S, Sherman DL, Nolan MF, Brophy PJ., Free PMC Article | 05/14/2011 |
| Results suggest that neurofascin-dependent assembly of the nodal complex acts as a molecular boundary, facilitating axonal domain organization and saltatory conduction along myelinated axons. | Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons.
Thaxton C, Pillai AM, Pribisko AL, Dupree JL, Bhat MA., Free PMC Article | 03/19/2011 |
| Nfasc isoforms use distinct protein-protein interaction modules to organize and stabilize specific axonal domains in myelinated axons: loss of Nfasc immunoglobulin domains 5 and 6 in mice mimics complete ablation of Nfasc. | In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons.
Thaxton C, Pillai AM, Pribisko AL, Labasque M, Dupree JL, Faivre-Sarrailh C, Bhat MA., Free PMC Article | 05/3/2010 |
| In both mouse and human samples, the expression pattern of neurofascin 155(high) and neurofascin 155(low) is altered coincident with paranodal decay. | Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis.
Pomicter AD, Shroff SM, Fuss B, Sato-Bigbee C, Brophy PJ, Rasband MN, Bhat MA, Dupree JL., Free PMC Article | 03/22/2010 |
| a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development | Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
Kirschbaum K, Kriebel M, Kranz EU, Pötz O, Volkmer H., Free PMC Article | 01/21/2010 |
| In the absence of glial Nfasc(NF155), paranodal axoglial junctions fail to form, axonal domains fail to segregate, and myelinated axons undergo degeneration. | Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains.
Pillai AM, Thaxton C, Pribisko AL, Cheng JG, Dupree JL, Bhat MA, Pillai AM, Thaxton C, Pribisko AL, Cheng JG, Dupree JL, Bhat MA., Free PMC Articles: PMC2837286, PMC2837286 | 01/21/2010 |
| Together, our studies establish a central role for paranodal axoglial junctions in both the organization and the maintenance of axonal domains in myelinated axons. | Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains.
Pillai AM, Thaxton C, Pribisko AL, Cheng JG, Dupree JL, Bhat MA, Pillai AM, Thaxton C, Pribisko AL, Cheng JG, Dupree JL, Bhat MA., Free PMC Articles: PMC2837286, PMC2837286 | 02/11/2009 |
| Glial and neuronal Neurofascins have distinct functions in the assembly of the central nervous system node of Ranvier. | Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.
Zonta B, Tait S, Melrose S, Anderson H, Harroch S, Higginson J, Sherman DL, Brophy PJ., Free PMC Article | 01/21/2010 |
| These results implicate ankyrin-based localization of L1CAMs, such as neurofascin, in subcellular organization of GABAergic synapses. | Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.
Ango F, di Cristo G, Higashiyama H, Bennett V, Wu P, Huang ZJ. | 01/21/2010 |