| Type 1 diabetic women delivering large for gestational age infants had lower placental GH levels in early pregnancy. | Lower levels of placental growth hormone in early pregnancy in women with type 1 diabetes and large for gestational age infants.
Ringholm L, Juul A, Pedersen-Bjergaard U, Thorsteinsson B, Damm P, Mathiesen ER. | 09/17/2016 |
| genetic association studies in populations in Estonia, Czech Republic, and Bashkortostan/Russia: Data suggest an SNP in GH2 (rs2006123) is associated with adult height (not body mass index); A-allele is associated with taller stature. [META-ANALYSIS] | Developmental programming of growth: genetic variant in GH2 gene encoding placental growth hormone contributes to adult height determination.
Timasheva Y, Putku M, Kivi R, Kožich V, Männik J, Laan M., Free PMC Article | 06/21/2014 |
| Maternal serum PGH at 11-13 weeks' gestation is unlikely to be a useful biochemical marker for early prediction of small for gestational age neonates. | Maternal serum placental growth hormone at 11-13 weeks' gestation in pregnancies delivering small for gestational age neonates.
Sifakis S, Akolekar R, Kappou D, Mantas N, Nicolaides KH. | 01/26/2013 |
| results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. | Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.
Männik J, Vaas P, Rull K, Teesalu P, Laan M., Free PMC Article | 07/14/2012 |
| These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in Type 1 Diabetic pregnancies. | Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.
Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM., Free PMC Article | 06/30/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.
McElholm AR, McKnight AJ, Patterson CC, Johnston BT, Hardie LJ, Murray LJ, Finbar Group. | 06/30/2010 |
| early first trimester maternal serum marker for Down syndrome | Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome.
Christiansen M. | 03/15/2010 |
| The hGH-V promoter activity and the endogenous mRNA expression in human placental choriocarcinoma cell line JAR in the presence of glucose and demethylating genome conditions, were compared. | hGH-V gene expression and promoter activity under glucose and 5-azacytidine (5azaC) effects.
de Jesús Romero-Prado MM, Barrera-Saldaña HA, Castrillo-Diez JL. | 02/22/2010 |
| Placental growth hormone (PGH) secretion by BeWo cells is regulated by hormonal factors and adipokines. Elevated insulin and leptin levels might down-regulate PGH secretion. | Regulation of placental growth hormone secretion in a human trophoblast model--the effects of hormones and adipokines.
Zeck W, Widberg C, Maylin E, Desoye G, Lang U, McIntyre D, Prins J, Russell A. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster.
Day IN, Chen XH, Gaunt TR, King TH, Voropanov A, Ye S, Rodriguez S, Syddall HE, Sayer AA, Dennison EM, Tabassum F, Barker DJ, Cooper C, Phillips DI. | 03/13/2008 |
| PGH may play a role in the mechanisms of disease in preeclampsia and fetal growth restriction. | Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia.
Mittal P, Espinoza J, Hassan S, Kusanovic JP, Edwin SS, Nien JK, Gotsch F, Than NG, Erez O, Mazaki-Tovi S, Romero R., Free PMC Article | 01/21/2010 |
| results offer the first evidence for a placental role of human placental growth hormone(hPGH) and suggest an autocrine/paracrine role of hPGH in the regulation of trophoblast invasion | Stimulation of human trophoblast invasion by placental growth hormone.
Lacroix MC, Guibourdenche J, Fournier T, Laurendeau I, Igout A, Goffin V, Pantel J, Tsatsaris V, Evain-Brion D. | 01/21/2010 |
| GH-V plays a major role in affecting target cells expressing the GH receptor, thus potentially exerting significant GH-like effects on maternal physiology during pregnancy. | Intracellular signaling by growth hormone variant (GH-V).
Silva CM, Kloth MT, Lyons CE, Dunn CR, Kirk SE. | 01/21/2010 |
| Data show that improved binding affinity of human growth hormone (hGH(v)) results from numerous small contributions distributed broadly over the interface. | The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Pal G, Kossiakoff AA, Sidhu SS. | 01/21/2010 |
| Using a mutagenesis-scanning analysis of 81 single and 32 pairwise double mutations, it is shown that the GHv hormone's two spatially distal receptor binding sites (Site1 and Site2) are allosterically coupled | The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Walsh ST, Sylvester JE, Kossiakoff AA., Free PMC Article | 01/21/2010 |
| report that autocrine hGH production by mammary carcinoma cells specifically results in the transcriptional repression of the p53-regulated placental transforming growth factor-beta gene (Placental growth factor-beta; TGF-beta) | Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells.
Graichen R, Liu D, Sun Y, Lee KO, Lobie PE. | 01/21/2010 |