| ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. | ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Cozzolino F, Vezzoli E, Cheroni C, Besusso D, Conforti P, Valenza M, Iacobucci I, Monaco V, Birolini G, Bombaci M, Falqui A, Saftig P, Rossi RL, Monti M, Cattaneo E, Zuccato C. | 04/2/2022 |
| Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function. | Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function.
Li P, Lin Z, An Y, Lin J, Zhang A, Wang S, Tu H, Ran J, Wang J, Liang Y, Liu Z, Ye C, Fu X, Gao J., Free PMC Article | 07/31/2021 |
| Loss of Piccolino, the synaptic ribbon specific splice variant of Piccolo, disrupts the characteristic plate-shaped structure of synaptic ribbons. | A Multiple Piccolino-RIBEYE Interaction Supports Plate-Shaped Synaptic Ribbons in Retinal Neurons.
Müller TM, Gierke K, Joachimsthaler A, Sticht H, Izsvák Z, Hamra FK, Fejtová A, Ackermann F, Garner CC, Kremers J, Brandstätter JH, Regus-Leidig H., Free PMC Article | 04/4/2020 |
| Piccolo puncta sandwiched Bassoon puncta and aligned in a Piccolo-Bassoon-Piccolo structure in adult neuromuscular junctions (NMJs). P/Q-type voltage-gated calcium channel (VGCC) puncta colocalized with Bassoon puncta. The P/Q-type VGCC and Bassoon protein levels decreased significantly in NMJs from aged mouse. In contrast, the Piccolo levels in NMJs from aged mice were comparable to levels in adult mice. | Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.
Nishimune H, Badawi Y, Mori S, Shigemoto K., Free PMC Article | 04/21/2018 |
| a function of Piccolino at ribbon synapses of sensory neurons | Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear.
Regus-Leidig H, Ott C, Löhner M, Atorf J, Fuchs M, Sedmak T, Kremers J, Fejtová A, Gundelfinger ED, Brandstätter JH., Free PMC Article | 04/5/2014 |
| a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis. | Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.
Waites CL, Leal-Ortiz SA, Okerlund N, Dalke H, Fejtova A, Altrock WD, Gundelfinger ED, Garner CC., Free PMC Article | 05/25/2013 |
| Piccolo is an important regulator of presynaptic F-actin, functioning to coordinate its activity-dependent assembly and thereby modulating neurotransmitter release. | Piccolo regulates the dynamic assembly of presynaptic F-actin.
Waites CL, Leal-Ortiz SA, Andlauer TF, Sigrist SJ, Garner CC., Free PMC Article | 11/19/2011 |
| piccolo and bassoon play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release. | Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.
Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC., Free PMC Article | 05/10/2010 |
| Piccolo plays a pivotal role in synaptic plasticity in area CA1 and in hippocampus-dependent learning in mice; the extracellular levels of glutamate in the hippocampus under stimulated conditions are controlled by Piccolo. | Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region.
Ibi D, Nitta A, Ishige K, Cen X, Ohtakara T, Nabeshima T, Ito Y. | 05/10/2010 |
| Piccolo C2A domain may act as a cytoskeletal regulator for plasmalemmal DAT internalization, which may underlie its contributions in behavioral plasticity. | Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization.
Cen X, Nitta A, Ibi D, Zhao Y, Niwa M, Taguchi K, Hamada M, Ito Y, Ito Y, Wang L, Nabeshima T. | 01/21/2010 |
| binds to cAMP-GEFII and forms both homodimer and heterodimer with Rim2 in a Ca(2+)-dependent manner, whereas Rim2 alone does not form the homodimer | Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis.
Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, Tajima N, Iwanaga T, Seino S. | 01/21/2010 |
| These results suggest that Piccolo is a components of neuromuscular junction synapses in the peripheral nervous system. | Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions.
Tokoro T, Higa S, Deguchi-Tawarada M, Inoue E, Kitajima I, Ohtsuka T. | 01/21/2010 |