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    STEAP1 STEAP family member 1 [ Homo sapiens (human) ]

    Gene ID: 26872, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis.

    Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis.
    Zhao S, Chen H, Zhou Y, Wang Q, Liang X, Yang N, Yan L, Yang J.

    01/5/2024
    Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells.

    Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells.
    Rocha SM, Santos FM, Socorro S, Passarinha LA, Maia CJ.

    08/19/2023
    Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.

    Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
    Zou X, Liu C, Huang Z, Xiang S, Li K, Yuan Y, Hao Y, Zhou F.

    06/30/2023
    STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide.

    STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide.
    Rocha SM, Nascimento D, Cardoso AM, Passarinha L, Socorro S, Maia CJ., Free PMC Article

    01/28/2023
    The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.

    The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
    Zhao C, Xiong K, Ji Z, Liu F, Li X., Free PMC Article

    04/9/2022
    Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.

    Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
    Zhao Z, Wang Z, Song Z, Wu Y, Jin Q, Zhao Z.

    03/19/2022
    Clinical significance of STEAP1 extracellular vesicles in prostate cancer.

    Clinical significance of STEAP1 extracellular vesicles in prostate cancer.
    Khanna K, Salmond N, Lynn KS, Leong HS, Williams KC., Free PMC Article

    02/5/2022
    Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma.

    Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma.
    Markey FB, Romero B, Parashar V, Batish M., Free PMC Article

    11/6/2021
    A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.

    A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
    Zhang Z, Hou WB, Zhang C, Tan YE, Zhang DD, An W, Pan SW, Wu WD, Chen QC, Xu HM., Free PMC Article

    05/22/2021
    The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.

    The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
    Wu HT, Chen WJ, Xu Y, Shen JX, Chen WT, Liu J., Free PMC Article

    04/24/2021
    STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway.

    STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway.
    Huo SF, Shang WL, Yu M, Ren XP, Wen HX, Chai CY, Sun L, Hui K, Liu LH, Wei SH, Wang XX, Wang Y, Tian YX., Free PMC Article

    03/27/2021
    Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1).

    Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1).
    Oosterheert W, Gros P., Free PMC Article

    01/16/2021
    Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition.

    Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition.
    Jiao Z, Huang L, Sun J, Xie J, Wang T, Yin X, Zhang H, Chen J.

    01/2/2021
    we identified high STEAP1 transcript levels leading to reduced ROS production that prevented apoptosis via the NRF2 pathway in CRC cells as a pathological mechanism in CRC.

    Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer.
    Nakamura H, Takada K, Arihara Y, Hayasaka N, Murase K, Iyama S, Kobune M, Miyanishi K, Kato J.

    07/11/2020
    Low STEAP1 expression was associated with Breast Cancer Metastasis.

    STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession.
    Xie J, Yang Y, Sun J, Jiao Z, Zhang H, Chen J.

    03/28/2020
    The expression of STEAP-1 is significantly associated with high-grade Gleason scores and seminal vesicle invasion of PCa.

    Six-Transmembrane Epithelial Antigen of the Prostate-1 (STEAP-1)-Targeted Ultrasound Imaging Microbubble Improves Detection of Prostate Cancer In Vivo.
    Yuan Y, Liu Y, Zhu XM, Hu J, Zhao CY, Jiang F.

    05/18/2019
    High STEAP1 expression is associated with prostate cancer.

    Knockdown of STEAP1 inhibits cell growth and induces apoptosis in LNCaP prostate cancer cells counteracting the effect of androgens.
    Gomes IM, Rocha SM, Gaspar C, Alvelos MI, Santos CR, Socorro S, Maia CJ.

    08/18/2018
    Data suggest a solid basis for further research into understanding how six-transmembrane epithelial antigen of prostate member 1 (STEAP1) activities may affect cancer progression.

    Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen.
    Kim K, Mitra S, Wu G, Berka V, Song J, Yu Y, Poget S, Wang DN, Tsai AL, Zhou M., Free PMC Article

    06/3/2017
    These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression

    Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET.
    Doran MG, Watson PA, Cheal SM, Spratt DE, Wongvipat J, Steckler JM, Carrasquillo JA, Evans MJ, Lewis JS., Free PMC Article

    01/31/2015
    Data indicate that six transmembrane epithelial antigen of the prostate 1 (STEAP1) is consistently overexpressed in malignant prostate tissue, namely adenocarcinoma and prostatic intraepithelial neoplasia (PIN) lesions.

    STEAP1 is overexpressed in prostate cancer and prostatic intraepithelial neoplasia lesions, and it is positively associated with Gleason score.
    Gomes IM, Arinto P, Lopes C, Santos CR, Maia CJ.

    09/27/2014
    The findings provide evidence that STEAP1 is a biomarker of worse prognosis in prostate carcinomas patients.

    STEAP1 protein overexpression is an independent marker for biochemical recurrence in prostate carcinoma.
    Ihlaseh-Catalano SM, Drigo SA, de Jesus CM, Domingues MA, Trindade Filho JC, de Camargo JL, Rogatto SR.

    07/26/2014
    STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate.

    Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells.
    Gomes IM, Santos CR, Socorro S, Maia CJ.

    06/1/2013
    A total of 62.3% of the Ewing's Sarcoma samples displayed detectable STEAP1 expression with predominant localization of the protein at the plasma membrane.

    High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients.
    Grunewald TGP, Ranft A, Esposito I, da Silva-Buttkus P, Aichler M, Baumhoer D, Schaefer KL, Ottaviano L, Poremba C, Jundt G, Jürgens H, Dirksen U, Richter GHS, Burdach S.

    11/24/2012
    STEAP1 is associated with the invasive behavior and oxidative stress phenotype of Ewing tumors, an unanticipated oncogenic function of STEAP1.

    STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors.
    Grunewald TG, Diebold I, Esposito I, Plehm S, Hauer K, Thiel U, da Silva-Buttkus P, Neff F, Unland R, Müller-Tidow C, Zobywalski C, Lohrig K, Lewandrowski U, Sickmann A, Prazeres da Costa O, Görlach A, Cossarizza A, Butt E, Richter GH, Burdach S.

    05/26/2012
    Studies suggest that activated human gammadelta T cells can efficiently present PRAME and STEAP1-derived epitopes and allow breaking tolerance against these tumor-associated self-antigens.

    Activated human γδ T cells induce peptide-specific CD8+ T-cell responses to tumor-associated self-antigens.
    Altvater B, Pscherer S, Landmeier S, Kailayangiri S, Savoldo B, Juergens H, Rossig C., Free PMC Article

    05/12/2012
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