| Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier. | Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier.
Wang Y, Wang C, Yang X, Ni K, Jiang L, Xu L, Liu Q, Xu X, Gu X, Liu Y, Ma Z. | 08/30/2024 |
| Intracellular and extracellular Cyclophilin a promote cardiac fibrosis through TGF-beta signaling in response to angiotensin . | Intracellular and extracellular Cyclophilin a promote cardiac fibrosis through TGF-β signaling in response to angiotensin Ⅱ.
Cao M, Zhao Q, Xia H, Lyu S, Luo J, Fu K, Chen R, Yuan W. | 07/15/2024 |
| High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-alpha. | High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-α.
Cui D, Yamamoto K, Ikeda E. | 03/27/2024 |
| Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. | Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model.
Stauffer WT, Goodman AZ, Bobardt M, Ure DR, Foster RT, Gallay P., Free PMC Article | 03/7/2024 |
| APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-beta. | APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β.
Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV., Free PMC Article | 07/20/2023 |
| Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets. | Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets.
Rosa A, Butt E, Hopper CP, Loroch S, Bender M, Schulze H, Sickmann A, Vorlova S, Seizer P, Heinzmann D, Zernecke A., Free PMC Article | 03/19/2022 |
| Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia. | Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Pasetto L, Grassano M, Pozzi S, Luotti S, Sammali E, Migazzi A, Basso M, Spagnolli G, Biasini E, Micotti E, Cerovic M, Carli M, Forloni G, De Marco G, Manera U, Moglia C, Mora G, Traynor BJ, Chiò A, Calvo A, Bonetto V., Free PMC Article | 02/26/2022 |
| Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin. | Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin.
Anandan V, Thulaseedharan T, Suresh Kumar A, Chandran Latha K, Revikumar A, Mullasari A, Kartha CC, Jaleel A, Ramachandran S., Free PMC Article | 01/8/2022 |
| Ppia is the most stable housekeeping gene for qRT-PCR normalization in kidneys of three Pkd1-deficient mouse models. | Ppia is the most stable housekeeping gene for qRT-PCR normalization in kidneys of three Pkd1-deficient mouse models.
Muñoz JJ, Anauate AC, Amaral AG, Ferreira FM, Watanabe EH, Meca R, Ormanji MS, Boim MA, Onuchic LF, Heilberg IP., Free PMC Article | 01/1/2022 |
| Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway. | Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway.
Zhang X, Zhu Y, Zhou Y, Fei B., Free PMC Article | 05/22/2021 |
| Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis. | Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis.
Leong KG, Ozols E, Kanellis J, Nikolic-Paterson DJ, Ma FY., Free PMC Article | 02/13/2021 |
| Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice. | Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice.
Hu H, Jiang J, Chen Q, Wei S, Liu M, Chen X, Fan C, Ma J, Chen W, Wang X, Zhong M. | 11/28/2020 |
| Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage. | Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage.
Pan P, Zhao H, Zhang X, Li Q, Qu J, Zuo S, Yang F, Liang G, Zhang JH, Liu X, He H, Feng H, Chen Y., Free PMC Article | 11/21/2020 |
| Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida. | Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida.
Rodrigues IS, Pereira LMG, Lisboa J, Pereira C, Oliveira P, Dos Santos NMS, do Vale A., Free PMC Article | 10/31/2020 |
| Loss of cyclophilin A results in altered peripheral immune activation and leukocyte infiltration. | The contribution of cyclophilin A to immune-mediated central nervous system inflammation.
Garimella V, McVoy JS, Oh U., Free PMC Article | 07/11/2020 |
| The present study reveals the positive correlation of CypA/CD147 signaling and osteoclast-related MMP-9 expression in mice inflammatory periapical lesions progression. Therefore, intervention of CypA/CD147 signaling could probably provide a potential therapeutic target for attenuating inflammatory bone resorption. | Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion.
Wang YQ, Zhang J, Zhu LX, Yu JJ, Liu MW, Zhu ST, Liu GJ, Peng B., Free PMC Article | 07/27/2019 |
| Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation. | Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.
von Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P., Free PMC Article | 08/11/2018 |
| Endothelial cell-derived CypA (especially AcK-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress. | Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation.
Xue C, Sowden M, Berk BC., Free PMC Article | 06/24/2017 |
| ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells. | Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain.
Su Z, Lin R, Chen Y, Shu X, Zhang H, Liang S, Nie R, Wang J, Xie S. | 05/13/2017 |
| knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro. | CD147 stimulates hepatoma cells escaping from immune surveillance of T cells by interaction with Cyclophilin A.
Ren YX, Wang SJ, Fan JH, Sun SJ, Li X, Padhiar AA, Zhang JN. | 02/4/2017 |
| CypA dually exerts pro-osteogenic and anti-osteoclastic effects. | Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption.
Guo M, James AW, Kwak JH, Shen J, Yokoyama KK, Ting K, Soo CB, Chiu RH., Free PMC Article | 01/14/2017 |
| Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA. | Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo.
Seizer P, Ungern-Sternberg SN, Schönberger T, Borst O, Münzer P, Schmidt EM, Mack AF, Heinzmann D, Chatterjee M, Langer H, Malešević M, Lang F, Gawaz M, Fischer G, May AE. | 04/16/2016 |
| CypA provided stability for NF-kappaB p65 and promoted NF-kappaB p65 nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB activity. | Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling.
Sun S, Guo M, Zhang JB, Ha A, Yokoyama KK, Chiu RH., Free PMC Article | 02/6/2016 |
| Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification. | Novel role for cyclophilin A in regulation of chondrogenic commitment and endochondral ossification.
Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH., Free PMC Article | 08/8/2015 |
| Cyclophilin A secretion was increased in lymphocytes from atherogenic mice. | Effects of OX40-OX40 ligand interaction on the levels of ROS and Cyclophilin A in C57BL/6J mice atherogenesis.
Yan J, Li Y, Wang Z, Liang Y, Yuan W, Wang C. | 06/20/2015 |