| GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma. | GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma.
Avenel ICN, Ewald JD, Ariey-Bonnet J, Kristensen IH, Petterson SA, Thesbjerg MN, Burton M, Thomassen M, Wennerberg K, Michaelsen SR, Kristensen BW., Free PMC Article | 09/10/2024 |
| The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRalpha1) in the Cryopreservation of Spermatogonia Stem Cells. | The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells.
Shamhari A', Jefferi NES, Abd Hamid Z, Budin SB, Idris MHM, Taib IS., Free PMC Article | 02/28/2023 |
| LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. | LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer.
Meng M, Wu YC., Free PMC Article | 07/23/2022 |
| CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. | CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression.
Bazhabayi M, Qiu X, Li X, Yang A, Wen W, Zhang X, Xiao X, He R, Liu P., Free PMC Article | 03/19/2022 |
| Deficiency of GFRalpha1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy. | Deficiency of GFRα1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy.
Zhu H, Huang M, Luo J, Ji X, Liu Q. | 03/5/2022 |
| LncRNA LINC00210 regulated radiosensitivity of osteosarcoma cells via miR-342-3p/GFRA1 axis. | LncRNA LINC00210 regulated radiosensitivity of osteosarcoma cells via miR-342-3p/GFRA1 axis.
He P, Xu YQ, Wang ZJ, Sheng B., Free PMC Article | 10/30/2021 |
| Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis. | Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis.
Arora V, Khan S, El-Hattab AW, Dua Puri R, Rocha ME, Merdzanic R, Paknia O, Beetz C, Rolfs A, Bertoli-Avella AM, Bauer P, Verma IC., Free PMC Article | 07/10/2021 |
| Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRalpha1 for Specific Infection of Breast Cancer Cells. | Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells.
Hall BL, Leronni D, Miyagawa Y, Goins WF, Glorioso JC, Cohen JB., Free PMC Article | 03/20/2021 |
| Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer. | Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer.
Dong Z, Dai L, Zhang Y, Fang C, Shi G, Chen Y, Li J, Wang Q, Fu J, Yu Y, Wang W, Cheng L, Liu Y, Lin Y, Wang Y, Wang Q, Wang H, Zhang H, Zhang Y, Su X, Zhang S, Wang F, Qiu M, Zhou Z, Deng H., Free PMC Article | 01/9/2021 |
| GFRA1 expression is frequently reactivated by DNA demethylation in colon cancer (CC) tissues and is significantly associated with a poor prognosis in patients with CC, especially those with metastatic CC. GFRA1 can promote the proliferation/growth of CC cells, probably by the activation of AKT and ERK pathways. | Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer.
Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ., Free PMC Article | 06/13/2020 |
| Low expression of EZH2 in the colon tissue of children with Hirschsprung's disease may be one of the causes of inadequate expression of GFRalpha1 and onset of Hirschsprung's disease | [Effect of enhancer of zeste homolog 2 on the expression of glial cell line-derived neurotrophic factor family receptor α-1 in the colon tissue of children with Hirschsprung's disease].
Zhao F, Zhou CG, Xu G, Ma TD, Xia RP, Li BX., Free PMC Article | 11/16/2019 |
| Data suggest that GDNF family receptor alpha 1 protein (GFRA1) is a protein target of ST3 beta-galactoside alpha-23-sialyltransferase 1 (ST3GAL1). | Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
Fan TC, Yeo HL, Hsu HM, Yu JC, Ho MY, Lin WD, Chang NC, Yu J, Yu AL. | 10/5/2019 |
| identified a novel susceptibility locus (rs3781545in GFRA1) with suggestive significance for migraine risk in Han Chinese | Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.
Chen SP, Fuh JL, Chung MY, Lin YC, Liao YC, Wang YF, Hsu CL, Yang UC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS, Shen-Jang Fann C, Wang SJ. | 07/27/2019 |
| circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. | circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.
He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z, Tang H., Free PMC Article | 06/2/2018 |
| the methylation status of CpG sites in GFRA1 and GSTM2 may have a role and could be used as potential biomarkers for the screening of rectal cancer | Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.
Wei J, Li G, Zhang J, Zhou Y, Dang S, Chen H, Wu Q, Liu M., Free PMC Article | 03/31/2018 |
| GFRA1 regulates AMPK-dependent autophagy by promoting SRC phosphorylation independent of proto-oncogene RET kinase | GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy.
Kim M, Jung JY, Choi S, Lee H, Morales LD, Koh JT, Kim SH, Choi YD, Choi C, Slaga TJ, Kim WJ, Kim DJ., Free PMC Article | 12/9/2017 |
| that the consequences of this is that GFRalpha-1-mediated signalling is altered during the ageing process | Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin.
Adly MA, Assaf HA, Hussein MR., Free PMC Article | 08/5/2017 |
| RET c.1296A may be a common susceptibility allele for nephron underdosing-related diseases. The 5'-UTR and intronic variants near exon 5 of GFRA1 are not associated with nephron endowment. | Association Between RET (rs1800860) and GFRA1 (rs45568534, rs8192663, rs181595401, rs7090693, and rs2694770) Variants and Kidney Size in Healthy Newborns.
Kaczmarczyk M, Loniewska B, Kuprjanowicz A, Binczak-Kuleta A, Goracy I, Ryder M, Taryma-Lesniak O, Ciechanowicz A. | 03/11/2017 |
| Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. | Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.
Catela C, Shin MM, Lee DH, Liu JP, Dasen JS., Free PMC Article | 12/17/2016 |
| This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts. | Lipid Rafts Are Physiologic Membrane Microdomains Necessary for the Morphogenic and Developmental Functions of Glial Cell Line-Derived Neurotrophic Factor In Vivo.
Tsui CC, Gabreski NA, Hein SJ, Pierchala BA., Free PMC Article | 01/2/2016 |
| Methylation changes of GFRA1, SRF, and ZNF382 may be a potential biomarker set for prediction of gastric carcinoma metastasis. | Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.
Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, Zhang L, Zhu B, Hattori N, Ji J, Yuasa Y, Kim W, Ushijima T, Shi H, Deng D., Free PMC Article | 07/25/2015 |
| GFRalpha1 levels in neurons from autopsied AD brains are significantly decreased. | Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death.
Konishi Y, Yang LB, He P, Lindholm K, Lu B, Li R, Shen Y., Free PMC Article | 11/29/2014 |
| In the cochlea, GFRalpha-1 was identified mainly in the cell bodies of the spiral neurons. In the organ of Corti, GFRalpha-1 was demonstrated in the Deiters' cells, Hensen cells, inner pillar cells, and weakly in inner hair cells but not in the outer hair cells. | Immunohistological analysis of neurturin and its receptors in human cochlea.
Liu W, Rask-Andersen H. | 10/25/2014 |
| These findings collectively demonstrate that GFRalpha1 released by nerves enhances perineural invasion through GDNF-RET signaling and that GFRalpha1 expression by cancer cells enhances but is not required for it. | GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
He S, Chen CH, Chernichenko N, He S, Bakst RL, Barajas F, Deborde S, Allen PJ, Vakiani E, Yu Z, Wong RJ., Free PMC Article | 07/12/2014 |
| The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon. | Site-specific gene expression and localization of growth factor ligand receptors RET, GFRα1 and GFRα2 in human adult colon.
Barrenschee M, Böttner M, Hellwig I, Harde J, Egberts JH, Becker T, Wedel T. | 06/7/2014 |