| GDF9[His209GlnfsTer6/S428T] and GDF9[Q321X/S428T] bi-allelic variants caused female subfertility with defective follicle enlargement. | GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.
Duan Y, Cai B, Guo J, Wang C, Mai Q, Xu Y, Zeng Y, Shi Y, Wang B, Ding C, Chen M, Zhou C, Xu Y., Free PMC Article | 05/22/2024 |
| Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males. | Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males.
Al-Rubaye DS, Mohammed Hamza H, Ahmed Al-Khafaji Q., Free PMC Article | 12/4/2023 |
| Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis. | Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis.
Huang TH, Chen FR, Zhang YN, Chen SQ, Long FY, Wei JJ, Zhang K, Zeng JZ, Zhu QY, Li-Ling J, Gong Y., Free PMC Article | 03/31/2023 |
| Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome. | Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome.
Riepsamen AH, Donoghoe MW, Indran IR, Hechtman L, Robertson DM, Gilchrist RB, Ledger WL, Yong EL., Free PMC Article | 03/17/2023 |
| GDF9 concentration in embryo culture medium is linked to human embryo quality and viability. | GDF9 concentration in embryo culture medium is linked to human embryo quality and viability.
Li J, Li C, Liu X, Yang J, Zhang Q, Han W, Huang G., Free PMC Article | 04/2/2022 |
| Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization. | Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization.
Meireles AJC, Bilibio JP, Lorenzzoni PL, Conto E, Nascimento FCD, Cunha-Filho JSD., Free PMC Article | 02/5/2022 |
| A homozygous truncating variant in GDF9 in siblings with primary ovarian insufficiency. | A homozygous truncating variant in GDF9 in siblings with primary ovarian insufficiency.
Verma KP, Thompson B, Wolfe J, Price S, Djukiadmodjo F, Trainer A., Free PMC Article | 12/11/2021 |
| New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause. | New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause.
Asiabi P, David C, Camboni A, Marbaix E, Dolmans MM, Amorim CA., Free PMC Article | 12/11/2021 |
| Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders. | Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders.
Gong Y, Li-Ling J, Xiong D, Wei J, Zhong T, Tan H., Free PMC Article | 09/4/2021 |
| Growth differentiation factor 9 inhibits vascular endothelial growth factor expression in human granulosa cells. | Growth differentiation factor 9 inhibits vascular endothelial growth factor expression in human granulosa cells.
Guo C, Chen M, Ma W, Cai B, Xu Y, Zhong Y, Zhou C. | 06/26/2021 |
| A variant of human growth differentiation factor-9 that improves oocyte developmental competence. | A variant of human growth differentiation factor-9 that improves oocyte developmental competence.
Stocker WA, Walton KL, Richani D, Chan KL, Beilby KH, Finger BJ, Green MP, Gilchrist RB, Harrison CA., Free PMC Article | 01/2/2021 |
| It was observed a statistically significant difference in genotype distribution of BMP15:c.852C>T between group POI and controls (p < 0.001). TT and TC genotypes were more frequently observed in group POI.. Concerning GDF9, no association was found among the studied genetic variants and POI or high FSH groups | Association of BMP15 and GDF9 variants to premature ovarian insufficiency.
Santos M, Cordts EB, Peluso C, Dornas M, Neto FHV, Bianco B, Barbosa CP, Christofolini DM., Free PMC Article | 03/21/2020 |
| Here, the Targeted massively parallel sequencing identified the first homozygous 1-bp deletion variant in GDF9. This finding reveals a novel inheritance pattern of pathogenic variant in GDF9 associated with primary ovarian insufficiency (POI), thus improving the genetic diagnosis of this disorder. | Identification of the first homozygous 1-bp deletion in GDF9 gene leading to primary ovarian insufficiency by using targeted massively parallel sequencing.
França MM, Funari MFA, Nishi MY, Narcizo AM, Domenice S, Costa EMF, Lerario AM, Mendonca BB. | 08/3/2019 |
| GDF9 promoted follicle-stimulating hormone (FSH)-induced progesterone production and STAR expression. | Growth differentiation factor 9 promotes follicle-stimulating hormone-induced progesterone production in chicken follicular granulosa cells.
Li J, Luo W, Huang T, Gong Y. | 05/18/2019 |
| GDF9 + BMP15, but not separately, significantly induce AMH expression in vitro and in vivo. GDF9 + BMP15, through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of H3K27ac, facilitating AMH expression. | Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells.
Roy S, Gandra D, Seger C, Biswas A, Kushnir VA, Gleicher N, Kumar TR, Sen A., Free PMC Article | 03/9/2019 |
| The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women. | GDF-9 and BMP-15 direct the follicle symphony.
Sanfins A, Rodrigues P, Albertini DF., Free PMC Article | 12/22/2018 |
| Data suggest that GDF9 and BMP15 are oocyte-secreted factors with leading roles in control of ovarian function in female reproduction, modulating both fate of somatic granulosa cells and quality/developmental competence of the egg. (GDF9 = growth and differentiation factor-9; BMP15 = bone morphogenetic protein-15) [REVIEW] | Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function.
Belli M, Shimasaki S., Free PMC Article | 11/10/2018 |
| GDF9 single nucleotide polymorphism is not associated with Endometriosis-associated infertility. | Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms.
De Conto E, Matte Ú, Bilibio JP, Genro VK, Souza CA, Leão DP, Cunha-Filho JS., Free PMC Article | 08/4/2018 |
| GDF9 single nucleotide polymorphism is associated with fecundity. | Genetic polymorphism of growth differentiation factor 9 (GDF9) gene related to fecundity in two Egyptian sheep breeds.
El Fiky ZA, Hassan GM, Nassar MI., Free PMC Article | 08/4/2018 |
| Asiaticoside hindered the invasive growth of KFs by inhibiting the GDF-9/MAPK/Smad pathway. | Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF-9/MAPK/Smad pathway.
Wu X, Bian D, Dou Y, Gong Z, Tan Q, Xia Y, Dai Y. | 12/23/2017 |
| Human GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways. | Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.
Reader KL, Mottershead DG, Martin GA, Gilchrist RB, Heath DA, McNatty KP, Juengel JL. | 04/15/2017 |
| these results indicated that the GDF9 C447T SNP is a possible candidate genetic risk factor for female infertility in the Polish population. | Effect of growth differentiation factor‑9 C447T and G546A polymorphisms on the outcomes of in vitro fertilization.
Serdyńska-Szuster M, Jędrzejczak P, Ożegowska KE, Hołysz H, Pawelczyk L, Jagodziński PP. | 02/18/2017 |
| GDF-9 promotes the proliferation and migration of keloid fibroblasts via a mechanism involving the Smad2/3 pathway. | Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway.
Jiang Z, Yu Q, Xia L, Zhang Y, Wang X, Wu X, Gao Z. | 02/18/2017 |
| GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population. | Single nucleotide polymorphisms in premature ovarian failure-associated genes in a Chinese Hui population.
Ma L, Chen Y, Mei S, Liu C, Ma X, Li Y, Jiang Y, Ha L, Xu X., Free PMC Article | 03/5/2016 |
| results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals. | Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality.
Mottershead DG, Sugimura S, Al-Musawi SL, Li JJ, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB., Free PMC Article | 12/19/2015 |