| Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice. | Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
Blottner D, Trautmann G, Furlan S, Gambara G, Block K, Gutsmann M, Sun LW, Worley PF, Gorza L, Scano M, Lorenzon P, Vida I, Volpe P, Salanova M., Free PMC Article | 02/5/2022 |
| The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells. | The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells.
Furuichi T, Muto Y, Sadakata T, Sato Y, Hayashi K, Shiraishi-Yamaguchi Y, Shinoda Y., Free PMC Article | 01/22/2022 |
| Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues. | Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
Reibring CG, Hallberg K, Linde A, Gritli-Linde A., Free PMC Article | 11/21/2020 |
| Data indicate decreased bone density in homer scaffolding proteins (omer2/3) double knockout (DKO) mice. | Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.
Son A, Kang N, Oh SY, Kim KW, Muallem S, Yang YM, Shin DM., Free PMC Article | 04/11/2020 |
| The present results provide novel cause-effect evidence supporting a role for CEA Homer2 in the regulation of both basal anxiety and the time-dependent intensification of negative affective states in individuals with a history of binge-drinking during adolescence. | Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking.
Lee KM, Coelho MA, Sern KR, Szumlinski KK., Free PMC Article | 07/21/2018 |
| detected an additional 15 novel Homer2-interacting proteins, most of which are part of the N-methyl-D-aspartate receptor signaling pathway. These results corroborate the central role Homer2 plays in glutamatergic transmission and expand the network of proteins potentially contributing to the behavioral abnormalities associated with altered Homer2 expression | A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.
Goulding SP, Szumlinski KK, Contet C, MacCoss MJ, Wu CC., Free PMC Article | 06/23/2018 |
| stress-alcohol locomotor cross-sensitization was regulated by Homer2. | Homer2 regulates alcohol and stress cross-sensitization.
Quadir SG, Santos JR, Campbell RR, Wroten MG, Singh N, Holloway JJ, Bal SK, Camarini R, Szumlinski KK., Free PMC Article | 01/14/2017 |
| NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 gene | Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
Smothers CT, Szumlinski KK, Worley PF, Woodward JJ., Free PMC Article | 08/20/2016 |
| mouse mutants homozygous for the targeted deletion of Homer2 present with early-onset rapidly progressive hearing loss. | HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.
Azaiez H, Decker AR, Booth KT, Simpson AC, Shearer AE, Huygen PL, Bu F, Hildebrand MS, Ranum PT, Shibata SB, Turner A, Zhang Y, Kimberling WJ, Cornell RA, Smith RJ., Free PMC Article | 01/2/2016 |
| Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells. | Homer2 protein regulates plasma membrane Ca²⁺-ATPase-mediated Ca²⁺ signaling in mouse parotid gland acinar cells.
Yang YM, Lee J, Jo H, Park S, Chang I, Muallem S, Shin DM., Free PMC Article | 01/31/2015 |
| This study deministrated that PFC Homer2 overexpression enhances cocaine-conditioned reward in mice. | Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.
Ary AW, Lominac KD, Wroten MG, Williams AR, Campbell RR, Ben-Shahar O, von Jonquieres G, Klugmann M, Szumlinski KK., Free PMC Article | 08/10/2013 |
| Homer 1b/c isoform is identical irrespective of the muscle; Homer 2a/b is instead characteristic of the slow-twitch phenotype. | Homer 2 antagonizes protein degradation in slow-twitch skeletal muscles.
Bortoloso E, Megighian A, Furlan S, Gorza L, Volpe P. | 03/9/2013 |
| These data support the over-arching hypothesis that augmented accumbens Homer2-mediated glutamate signaling may be an endophenotype related to genetic variance in alcohol consumption | Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?
Goulding SP, Obara I, Lominac KD, Gould AT, Miller BW, Klugmann M, Szumlinski KK., Free PMC Article | 04/30/2011 |
| Homer2 and Homer3 proteins interact specifically with amyloid precursor protein (APP) by inhibiting APP processing and reducing secretion of Abeta peptides. | Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S. | 01/21/2010 |
| Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice. | Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice.
Szumlinski KK, Ary AW, Lominac KD, Klugmann M, Kippin TE., Free PMC Article | 01/21/2010 |
| study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin | NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF., Free PMC Article | 01/21/2010 |
| In the developing olfactory bulb, Cupidin/Homer 2a/b is up-regulated in the granular, external plexiform, and glomerular layers | Differential expression of Homer family proteins in the developing mouse brain.
Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, Furuichi T. | 01/21/2010 |
| Homer2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. | Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities.
Shin DM, Dehoff M, Luo X, Kang SH, Tu J, Nayak SK, Ross EM, Worley PF, Muallem S., Free PMC Article | 01/21/2010 |
| necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticity | Homer2 is necessary for EtOH-induced neuroplasticity.
Szumlinski KK, Lominac KD, Oleson EB, Walker JK, Mason A, Dehoff MH, Klugmann M, Cagle S, Welt K, During M, Worley PF, Middaugh LD, Kalivas PW., Free PMC Article | 01/21/2010 |
| Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression. | HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
Ajima R, Kajiya K, Inoue T, Tani M, Shiraishi-Yamaguchi Y, Maeda M, Segawa T, Furuichi T, Sutoh K, Yokota J. | 01/21/2010 |
| Homer2 KO mice demonstrate enhanced locomotor stimulant and conditioned place preference responses to cocaine | Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats.
Kalivas PW, Szumlinski KK, Worley P. | 01/21/2010 |