| In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex. | In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.
Hassi NK, Weston T, Rinaldi G, Ng JC, Smahi A, Twelves S, Davan-Wetton C, Fakhreddine D, Fraternali F, Capon F., Free PMC Article | 11/30/2023 |
| Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia. | Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia.
Choon SE, Tok PSK, Wong KW, Lim YT, Nanu NM, Barker JN, Capon F. | 08/22/2023 |
| Deficiency of interleukin-36 receptor antagonist (DITRA): An analysis of 58 Chinese patients in a tertiary hospital in Taiwan. | Deficiency of interleukin-36 receptor antagonist (DITRA): An analysis of 58 Chinese patients in a tertiary hospital in Taiwan.
Hsieh CY, Huang YW, Huang YH, Tsai TF. | 08/22/2023 |
| Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population. | Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population.
Zhang Q, Shi P, Wang Z, Sun L, Li W, Zhao Q, Liu T, Pan Q, Sun Y, Jia F, Chen W, Fu X, Yu G, Bao F, Mi Z, Wang C, Sun Y, Li B, Liu J, Liu H, Gu H, Zhang F. | 07/25/2023 |
| Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis. | Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis.
Trai NN, Van Em D, Van BT, My LH, Van Tro C, Hao NT, Vu HA, Tram DB, Van Thuong N, Doanh LH. | 06/23/2023 |
| Different Clinical Features of Pediatric Generalized Pustular Psoriasis in Patients with or without IL36RN Variants. | Different Clinical Features of Pediatric Generalized Pustular Psoriasis in Patients with or without IL36RN Variants.
Wang Z, Xiang X, Chen Y, Qi Z, Miao C, Liu Y, Zhao X, Zhang Y, Zhang Z, Li W, Xu Z, Ma L. | 03/7/2023 |
| IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic. | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
Dong H, Hao Y, Li W, Yang W, Gao P., Free PMC Article | 08/6/2022 |
| IL-36gamma and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. | IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death.
Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D, Zhong B., Free PMC Article | 02/12/2022 |
| Down-regulated IL36RN expression based on peripheral blood mononuclear cells and plasma of periodontitis patients and its clinical significance. | Down-regulated IL36RN expression based on peripheral blood mononuclear cells and plasma of periodontitis patients and its clinical significance.
Zhou Y, Liang Y., Free PMC Article | 01/29/2022 |
| Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation. | Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation.
Li H, Liao D, Meng S, Liu J, Li S, Ni S, Xu Y, Zhao Y, Zhou W. | 01/29/2022 |
| SARS-CoV-2 infection inducing severe flare up of Deficiency of Interleukin Thirty-six (IL-36) Receptor Antagonist (DITRA) resulting from a mutation invalidating the activating cleavage site of the IL-36 receptor antagonist. | SARS-CoV-2 infection inducing severe flare up of Deficiency of Interleukin Thirty-six (IL-36) Receptor Antagonist (DITRA) resulting from a mutation invalidating the activating cleavage site of the IL-36 receptor antagonist.
Bozonnat A, Assan F, LeGoff J, Bourrat E, Bachelez H., Free PMC Article | 10/2/2021 |
| Association between mutation of interleukin 36 receptor antagonist and generalized pustular psoriasis: A PRISMA-compliant systematic review and meta-analysis. | Association between mutation of interleukin 36 receptor antagonist and generalized pustular psoriasis: A PRISMA-compliant systematic review and meta-analysis.
Liu ZJ, Tian YT, Shi BY, Zhou Y, Jia XS., Free PMC Article | 11/21/2020 |
| IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis. | IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis.
Catapano M, Vergnano M, Romano M, Mahil SK, Choon SE, Burden AD, Young HS, Carr IM, Lachmann HJ, Lombardi G, Smith CH, Ciccarelli FD, Barker JN, Capon F., Free PMC Article | 11/21/2020 |
| Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome. | Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome.
Bal E, Lim AC, Shen M, Douangpanya J, Madrange M, Gazah R, Tauber M, Beghdadi W, Casanova JL, Bourrat E, Bachelez H, Towne JE, Smahi A. | 09/12/2020 |
| mutations c.140A>G/p.Asn47Ser; c.258G>A/p.Met86IIe; c.115+6T>C and c.169G>A/p.Val57IIe did not appear to be associated with the specific phenotypes of palmoplantar pustulosis. | Lack of association between mutation in IL36RN and palmoplantar pustular psoriasis in Chinese patients.
Xiaoling Y, Dan S, Hongzhong J., Free PMC Article | 03/7/2020 |
| The IL36RN gene mutation is not a constant condition in drug-induced AGEP. | Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations.
Chadli Z, Ladhari C, Kerkeni E, Djobbi A, Fredj NB, Chaabane A, Boughattas NA, Aouam K. | 08/17/2019 |
| The results show, significant correlation of IL36RN mutations with a younger age at psoriasis onset. Psoriasis patients with IL36RN mutations, carried an additional rare variant in either CARD14 or AP1S3, indicating a more complex inheritance. | The genetic basis for most patients with pustular skin disease remains elusive.
Mössner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Löhr S, Schulz P, Körber A, Prinz JC, Renner R, Schäkel K, Vogelsang L, Peters KP, Philipp S, Reich K, Ständer H, Jacobi A, Weyergraf A, Kingo K, Kõks S, Gerdes S, Steinz K, Schill T, Griewank KG, Müller M, Frey S, Ebertsch L, Uebe S, Sticherling M, Sticht H, Hüffmeier U. | 06/22/2019 |
| Letter/Case Report: generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency. | An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency.
Oi R, Takeichi T, Okuno Y, Kojima D, Sugawara K, Kono M, Muramatsu H, Akiyama M. | 06/1/2019 |
| IL36RN may be the most common disease-causing gene in the patients with generalized pustular psoriasis in the Han population from Sichuan region. | [Genetic Polymorphism of IL36RN in Han Patients with Generalized Pustular Psoriasis Alone in Sichuan Region].
Li ZT, Wang S. | 03/23/2019 |
| systemic lupus erythematosus patients had significantly decreased serum IL-36Ra levels | Increased serum IL-36α and IL-36γ levels in patients with systemic lupus erythematosus: Association with disease activity and arthritis.
Mai SZ, Li CJ, Xie XY, Xiong H, Xu M, Zeng FQ, Guo Q, Han YF. | 10/27/2018 |
| IL36RN may be the major disease-causing gene in generalized pustular psoriasis patients in Han population in Sichuan region of China. | Genetic polymorphism of IL36RN in Han patients with generalized pustular psoriasis in Sichuan region of China: A case-control study.
Li Z, Yang Q, Wang S., Free PMC Article | 09/1/2018 |
| IL36RN mutations were strongly linked with early onset and hyponychial pustules, but not with therapeutic efficacy of acitretin or recurrence frequency. Early onset and hyponychial pustules may be specific to IL36RN mutation, however this alone is an insufficient biomarker for acitretin therapy. | Association of IL36RN mutations with clinical features, therapeutic response to acitretin, and frequency of recurrence in patients with generalized pustular psoriasis.
Zhu T, Jin H, Shu D, Li F, Wu C. | 09/1/2018 |
| Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form. | Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist.
Macleod T, Doble R, McGonagle D, Wasson CW, Alase A, Stacey M, Wittmann M., Free PMC Article | 01/27/2018 |
| A study on the association of IL36RN mutations that affect protein expression and function with phenotype in patients with generalized pustular psoriasis. | IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases.
Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, Zenati A, Makrelouf M, Boubridaa K, Chiali A, Smahi N, Otsmane F, Bouajar B, Marrakchi S, Turki H, Bourrat E, Viguier M, Hamel Y, Bachelez H, Smahi A. | 09/2/2017 |
| The findings indicate that IL36RN mutations do not seem to contribute to the pathogenesis of common, nonpustular forms of psoriasis, but to the rarer pustular manifestations such as GPP, acrodermatitis continua suppurativa of Hallopeau and acute generalized exanthematous pustulosis. | Association analysis of psoriasis vulgaris and psoriatic arthritis with loss-of-function mutations in IL36RN in German patients.
Löhr S, Uebe S, Behrens F, Böhm B, Köhm M, Traupe H, Oji V, Burkhardt H, Reis A, Hüffmeier U. | 08/19/2017 |