| Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis. | Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.
Ghoshal K, Luther JM, Pakala SB, Chetyrkin S, Falck JR, Zent R, Wasserman DH, Pozzi A., | 07/24/2024 |
| Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs. | Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.
Shi X, Pang S, Zhou J, Yan G, Gao R, Wu H, Wang Z, Wei Y, Liu X, Tan W., Free PMC Article | 03/28/2024 |
| Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer. | Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer.
Shi X, Pang S, Zhou J, Yan G, Sun J, Tan W. | 12/10/2022 |
| Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis. | Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.
Kim JL, Mestre B, Malitsky S, Itkin M, Kupervaser M, Futerman AH., Free PMC Article | 05/7/2022 |
| Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy. | Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy.
Adeshakin AO, Liu W, Adeshakin FO, Afolabi LO, Zhang M, Zhang G, Wang L, Li Z, Lin L, Cao Q, Yan D, Wan X. | 09/11/2021 |
| Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression. | Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression.
Khan S, Gaivin R, Abramovich C, Boylan M, Calles J, Schelling JR., Free PMC Article | 06/5/2021 |
| Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis. | Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Chen Y, Yan Q, Lv M, Song K, Dai Y, Huang Y, Zhang L, Zhang C, Gao H., Free PMC Article | 05/1/2021 |
| Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARalpha-regulated genes. | Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes.
Perez VM, Gabell J, Behrens M, Wase N, DiRusso CC, Black PN., Free PMC Article | 12/26/2020 |
| mouse and human polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) exclusively upregulate fatty acid transport protein 2 (FATP2); FATP2 mediates the acquisition of immunosuppressive activity by PMN-MDSCs and represents a target to inhibit the functions of PMN-MDSCs selectively and to improve the efficiency of cancer therapy | Fatty acid transport protein 2 reprograms neutrophils in cancer.
Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI., Free PMC Article | 09/14/2019 |
| We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression. | Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2).
Khan S, Cabral PD, Schilling WP, Schmidt ZW, Uddin AN, Gingras A, Madhavan SM, Garvin JL, Schelling JR., Free PMC Article | 07/20/2019 |
| SLC27A2 is required for the transcriptional induction of miR-411 in ovarian cancer. Reduced miR-411 expression contributes to ovarian cancer chemo-resistance. | SLC27A2 regulates miR-411 to affect chemo-resistance in ovarian cancer.
Chen FD, Chen HH, Ke SC, Zheng LR, Zheng XY. | 07/6/2019 |
| Contractile strength in FATP2-knockdown gallbladders was significantly greater than in control gallbladders following lithogenic diet administration. FATP2-knockdown significantly reduced gallbladder triacylglycerol. | Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis.
Tharp KM, Khalifeh-Soltani A, Park HM, Yurek DA, Falcon A, Wong L, Feng R, Atabai K, Stahl A., Free PMC Article | 06/10/2017 |
| In mice Grassofermata decreased absorption of (13)C-oleate demonstrating its potential as a therapeutic agent. | Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity.
Saini N, Black PN, Montefusco D, DiRusso CC., Free PMC Article | 11/28/2015 |
| even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth | The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
Mishima T, Miner JH, Morizane M, Stahl A, Sadovsky Y., Free PMC Article | 02/25/2012 |
| FATP2 is a multifunctional protein that shows subcellular localization-dependent activity and is a major contributor ro peroxisomal (V)LACS activity. | FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.
Falcon A, Doege H, Fluitt A, Tsang B, Watson N, Kay MA, Stahl A., Free PMC Article | 10/23/2010 |
| PPARalpha up-regulates the expression of Slc27a2 in small intestine. | PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine.
Hirai T, Fukui Y, Motojima K. | 01/21/2010 |
| mouse VLCS gene (Vlcs) encodes an enzyme (Vlcs) with VLCS activity that localizes to peroxisomes and is expressed in X-ALD target tissues | Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy.
Heinzer AK, Kemp S, Lu JF, Watkins PA, Smith KD. | 01/21/2010 |