| Long non-coding RNA lung cancer-associated transcript 1 regulates ferroptosis via microRNA-34a-5p-mediated GTP cyclohydrolase 1 downregulation in lung cancer cells. | Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.
Tai F, Zhai R, Ding K, Zhang Y, Yang H, Li H, Wang Q, Cao Z, Ge C, Fu H, Xiao F, Zheng X., Free PMC Article | 07/18/2024 |
| GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner. | GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner.
Wang Z, Zhang N, Zhang M, Jiang Y, Ng AS, Bridges E, Zhang W, Zeng X, Luo Q, Liang J, Győrffy B, Hublitz P, Liang Z, Fischer R, Kerr D, Harris AL, Cai S. | 07/12/2024 |
| Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1.
Jung-Klawitter S, Richter P, Yuan Y, Welzel K, Kube M, Bähr S, Leibner A, Flory E, Opladen T. | 06/3/2024 |
| Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo. | Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo.
Yin YL, Chen Y, Ren F, Wang L, Zhu ML, Lu JX, Wang QQ, Lu CB, Liu C, Bai YP, Wang SX, Wang JZ, Li P., Free PMC Article | 12/17/2022 |
| CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. | CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis.
Jiang Y, Zhao J, Li R, Liu Y, Zhou L, Wang C, Lv C, Gao L, Cui D., Free PMC Article | 10/29/2022 |
| Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease. | Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease.
Pu JL, Lin ZH, Zheng R, Yan YQ, Xue NJ, Yin XZ, Zhang BR., Free PMC Article | 05/14/2022 |
| GCH1 mutations in hereditary spastic paraplegia. | GCH1 mutations in hereditary spastic paraplegia.
Varghaei P, Yoon G, Estiar MA, Veyron S, Leveille E, Dupré N, Trempe JF, Rouleau GA, Gan-Or Z. | 02/12/2022 |
| Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia. | Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia.
Romero J, Costa GMF, Rocha LPC, Siqueira S, Moreira PR, Almeida-Leite CM. | 01/29/2022 |
| Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. | Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, Hinz I, Feiler M, Müller K, Nar H. | 12/11/2021 |
| Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension. | Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension.
Wu Y, Ding Y, Ramprasath T, Zou MH., Free PMC Article | 12/4/2021 |
| Increased superoxide in GCH1 mutant fibroblasts points to a dopamine-independent toxicity mechanism. | Increased superoxide in GCH1 mutant fibroblasts points to a dopamine-independent toxicity mechanism.
Terbeek J, Martin S, Imberechts D, Kinnart I, Vangheluwe P, Nicholl D, Vandenberghe W. | 11/27/2021 |
| GTP Cyclohydrolase I as a Potential Drug Target: New Insights into Its Allosteric Modulation via Normal Mode Analysis. | GTP Cyclohydrolase I as a Potential Drug Target: New Insights into Its Allosteric Modulation via Normal Mode Analysis.
Khairallah A, Ross CJ, Tastan Bishop Ö. | 10/30/2021 |
| Association of TOR1A and GCH1 Polymorphisms with Isolated Dystonia in India. | Association of TOR1A and GCH1 Polymorphisms with Isolated Dystonia in India.
Giri S, Ghosh A, Roy S, Sankhla CS, Das SK, Ray K, Ray J. | 10/9/2021 |
| Brain structural alterations in patients with GCH1 mutations associated DOPA-responsive dystonia. | Brain structural alterations in patients with GCH1 mutations associated DOPA-responsive dystonia.
Kostić VS, Agosta F, Tomic A, Sarasso E, Kresojevic N, Basaia S, Svetel M, Copetti M, Filippi M. | 09/18/2021 |
| Molecular and metabolic bases of tetrahydrobiopterin (BH4) deficiencies. | Molecular and metabolic bases of tetrahydrobiopterin (BH(4)) deficiencies.
Himmelreich N, Blau N, Thöny B. | 09/11/2021 |
| Epigenetic silencing of GCH1promotes hepatocellular carcinoma growth by activating superoxide anion-mediated ASK1/p38 signaling via inhibiting tetrahydrobiopterin de novo biosynthesis. | Epigenetic silencing of GCH1promotes hepatocellular carcinoma growth by activating superoxide anion-mediated ASK1/p38 signaling via inhibiting tetrahydrobiopterin de novo biosynthesis.
Zhong GC, Zhao ZB, Cheng Y, Wang YB, Qiu C, Mao LH, Hu JJ, Cai D, Liu Y, Gong JP, Li SW. | 08/21/2021 |
| GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study. | GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study.
Pan HX, Zhao YW, Mei JP, Fang ZH, Wang Y, Zhou X, Zhou YJ, Zhang R, Zhang KL, Jiang L, Zeng Q, He Y, Wang Z, Liu ZH, Xu Q, Sun QY, Yang Y, Hu YC, Chen YS, Du J, Lei LF, Zhang HN, Wang CY, Yan XX, Shen L, Jiang H, Tan JQ, Li JC, Tang BS, Guo JF., Free PMC Article | 07/24/2021 |
| Autosomal dominant GCH1 mutations causing spastic paraplegia at disease onset. | Autosomal dominant GCH1 mutations causing spastic paraplegia at disease onset.
Wassenberg T, Schouten MI, Helmich RC, Willemsen MAAP, Kamsteeg EJ, van de Warrenburg BPC. | 06/26/2021 |
| A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, Reinert D, Bauer M, Weixler L, Zeeb M, Vonck J, Nar H., Free PMC Article | 02/6/2021 |
| GCH1 (rs841) polymorphism in the nitric oxide-forming pathway has protective effects on obstructive sleep apnea. | GCH1 (rs841) polymorphism in the nitric oxide-forming pathway has protective effects on obstructive sleep apnea.
Sheikhi Kouhsar S, Bigdeli M, Shakiba Y, Sadeghniiat K., Free PMC Article | 11/21/2020 |
| A tetrahydrobiopterin deficit finding in schizophrenia: A confirmation study. | A tetrahydrobiopterin deficit finding in schizophrenia: A confirmation study.
Clelland JD, Smeed J, Cremers S, Clelland CL., Free PMC Article | 09/19/2020 |
| CTRP13 preserves endothelial function in diabetic mice by regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the therapeutic potential of CTRP13 against diabetic vasculopathy. | CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes.
Wang C, Chao Y, Xu W, Liang M, Deng S, Zhang D, Huang K. | 07/11/2020 |
| the rs3783641 single-nucleotide polymorphism in the GCH1 gene is associated with post-herpetic neuralgia, and the AA genotype showed a protective effect in post-herpetic neuralgia. | Association of rs3783641 single-nucleotide polymorphism in GTP cyclohydrolase 1 gene with post-herpetic neuralgia.
Zheng NN, Zhang RC, Yang XX, Zhong LS. | 04/18/2020 |
| Common and rare GCH1 genetic variants are associated with Parkinson's disease. | Common and rare GCH1 variants are associated with Parkinson's disease.
Rudakou U, Ouled Amar Bencheikh B, Ruskey JA, Krohn L, Laurent SB, Spiegelman D, Liong C, Fahn S, Waters C, Monchi O, Fon EA, Dauvilliers Y, Alcalay RN, Dupré N, Gan-Or Z., Free PMC Article | 12/21/2019 |
| Mechanistically, human antigen R (HuR) bound with the adenylateuridylate-rich elements of the GTPCH1 3' untranslated region and increased its stability; nicotine inhibited HuR translocation from the nucleus to cytosol, which downregulated GTPCH1. | Nicotine induces endothelial dysfunction and promotes atherosclerosis via GTPCH1.
Li J, Liu S, Cao G, Sun Y, Chen W, Dong F, Xu J, Zhang C, Zhang W., Free PMC Article | 12/14/2019 |