| Nr5a2 is dispensable for zygotic genome activation but essential for morula development. | Nr5a2 is dispensable for zygotic genome activation but essential for morula development.
Festuccia N, Vandormael-Pournin S, Chervova A, Geiselmann A, Langa-Vives F, Coux RX, Gonzalez I, Collet GG, Cohen-Tannoudji M, Navarro P. | 10/4/2024 |
| Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2. | Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2.
Huang X, Wei L, Li M, Zhang Y, Kuang S, Shen Z, Liu H, Lin Z., Free PMC Article | 07/31/2024 |
| Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle. | Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle.
Han HK, Mukherjee S, Park SY, Lee JH, Lee EH, Kim S, Lee YH, Song DK, Lee S, Bae JH, Im SS., | 07/12/2024 |
| Ovarian ERbeta cistrome and transcriptome reveal chromatin interaction with LRH-1. | Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.
Birgersson M, Indukuri R, Lindquist L, Stepanauskaite L, Luo Q, Deng Q, Archer A, Williams C., Free PMC Article | 12/6/2023 |
| Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. | Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Zapata RC, Zhang D, Libster A, Porcu A, Montilla-Perez P, Nur A, Xu B, Zhang Z, Correa SM, Liu C, Telese F, Osborn O., Free PMC Article | 11/16/2023 |
| LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis. | LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis.
Hu J, Zhang Z, Hu H, Yang K, Zhu Z, Yang Q, Liang W., Free PMC Article | 11/10/2023 |
| Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. | Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
Ahmed A, Reinhold C, Breunig E, Phan TS, Dietrich L, Kostadinova F, Urwyler C, Merk VM, Noti M, Toja da Silva I, Bode K, Nahle F, Plazzo AP, Koerner J, Stuber R, Menche C, Karamitopoulou E, Farin HF, Gollob KJ, Brunner T., Free PMC Article | 08/4/2023 |
| NR5A2 as a potential target for exercise to improve metabolic syndrome. | NR5A2 as a potential target for exercise to improve metabolic syndrome.
Meng L, Dong F, Deng J., Free PMC Article | 04/26/2023 |
| Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. | Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
Chen HJ, Barske L, Talbot JC, Dinwoodie OM, Roberts RR, Farmer DT, Jimenez C, Merrill AE, Tucker AS, Crump JG., Free PMC Article | 03/30/2023 |
| Zygotic genome activation by the totipotency pioneer factor Nr5a2. | Zygotic genome activation by the totipotency pioneer factor Nr5a2.
Gassler J, Kobayashi W, Gáspár I, Ruangroengkulrith S, Mohanan A, Gómez Hernández L, Kravchenko P, Kümmecke M, Lalic A, Rifel N, Ashburn RJ, Zaczek M, Vallot A, Cuenca Rico L, Ladstätter S, Tachibana K. | 01/7/2023 |
| Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice. | Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice.
Guzmán A, Hughes CHK, Murphy BD. | 11/19/2022 |
| Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism. | Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism.
Pantha R, Lee JH, Bae JH, Koh EH, Shin M, Song DK, Im SS., Free PMC Article | 01/29/2022 |
| Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus. | Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus.
Tsampoula M, Tarampoulous I, Antoniadou I, Koutmani Y, Gkikas D, Vekrellis K, Politis PK. | 11/22/2021 |
| The combined action of Esrrb and Nr5a2 is essential for murine naive pluripotency. | The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.
Festuccia N, Owens N, Chervova A, Dubois A, Navarro P., Free PMC Article | 11/6/2021 |
| A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation. | A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation.
Meinsohn MC, Hughes CHK, Estienne A, Saatcioglu HD, Pépin D, Duggavathi R, Murphy BD., Free PMC Article | 08/21/2021 |
| Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions. | Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions.
Cobo I, Iglesias M, Flández M, Verbeke C, Del Pozo N, Llorente M, Lawlor R, Luchini C, Rusev B, Scarpa A, Real FX. | 06/12/2021 |
| Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes. | Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes.
Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Putluri N, Suh JM, Wang MC, Moore DD., Free PMC Article | 02/20/2021 |
| The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility. | The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility.
Bianco S, Bellefleur AM, Beaulieu É, Beauparlant CJ, Bertolin K, Droit A, Schoonjans K, Murphy BD, Gévry N. | 08/29/2020 |
| This study describes a novel and critical role of LRH-1 in T cell maturation, functions, and immopathologies and proposes LRH-1 as an emerging pharmacological target in the treatment of T cell-mediated inflammatory diseases. | The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions.
Seitz C, Huang J, Geiselhöringer AL, Galbani-Bianchi P, Michalek S, Phan TS, Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado E, Schnalzger T, Schoonjans K, Brunner T., Free PMC Article | 05/9/2020 |
| Study reports an essential role for LRH-1 in hepatic lipid storage and phospholipid composition based on an acute hepatic KO of LRH-1 in adult mice. LRH-1-deficient mice fed high-fat diet displayed macrovesicular steatosis, liver injury, and glucose intolerance. Findings reveal a role for the phospholipid sensor LRH-1 in maintaining adequate pools of hepatic arachidonoyl phospholipids. | LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA., Free PMC Article | 12/7/2019 |
| role for NR5A2 and its SUMOylation on the transcriptional regulation of the calreticulin gene in a model of renal fibrosis | Nuclear receptor NR5A2 is involved in the calreticulin gene regulation during renal fibrosis.
Arvaniti E, Vakrakou A, Kaltezioti V, Stergiopoulos A, Prakoura N, Politis PK, Charonis A. | 02/2/2019 |
| Nr5a2 s a key component of an expanded primordial germ cells gene regulatory network. | Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.
Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA., Free PMC Article | 01/19/2019 |
| LRH-1 maintains intestinal epithelial health and protects against inflammatory damage. | LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA., Free PMC Article | 01/12/2019 |
| LRH-1 agonism favors an immune cells-islet dialogue which protects against diabetes mellitus. | LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR., Free PMC Article | 12/22/2018 |
| potent suppressor of neural stem cell self-renewal and key player in neural fate decisions through direct regulatory effects on critical genes and pathways | Nuclear receptor NR5A2 controls neural stem cell fate decisions during development.
Stergiopoulos A, Politis PK., Free PMC Article | 09/1/2018 |