| MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer's disease. | MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer's disease.
Wan W, Liu G, Li X, Liu Y, Wang Y, Pan H, Hu J., Free PMC Article | 02/19/2022 |
| Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. | Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
Li Y, Ritchie EM, Steinke CL, Qi C, Chen L, Zheng B, Jin Y., Free PMC Article | 01/29/2022 |
| Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions. | Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions.
Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML, Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P, Ray WJ., Free PMC Article | 02/20/2021 |
| Study shows that dual leucine zipper kinase inhibition preserves neuronal network connectivity. | High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH., Free PMC Article | 06/27/2020 |
| Using a sensory neuron-conditional DLK knockout mouse model, we show a time course for the dependency of gene expression changes on the DLK pathway after sciatic nerve injury. | DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.
Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A., Free PMC Article | 01/11/2020 |
| DLK is required for mechanical allodynia and microgliosis after nerve injury by controling a transcriptional program in somatosensory neurons regulating the expression of numerous genes implicated in pain pathogenesis, including Csf1. | Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury.
Wlaschin JJ, Gluski JM, Nguyen E, Silberberg H, Thompson JH, Chesler AT, Le Pichon CE., Free PMC Article | 03/23/2019 |
| These findings demonstrate that pathological activation of DLK is a conserved mechanism that regulates neurodegeneration. | Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW. | 05/5/2018 |
| These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration. | Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.
Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA., Free PMC Article | 01/6/2018 |
| Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function. | Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells.
Blondeau A, Lucier JF, Matteau D, Dumont L, Rodrigue S, Jacques PÉ, Blouin R., Free PMC Article | 09/23/2017 |
| LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. | Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ., Free PMC Article | 08/5/2017 |
| the prevention of the nuclear localization of DLK as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus | Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E. | 11/5/2016 |
| Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK does not appear to have a critical function in axonal degeneration; function appears restricted to soma | DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.
Fernandes KA, Harder JM, John SW, Shrager P, Libby RT., Free PMC Article | 03/21/2015 |
| This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates | ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.
Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A., Free PMC Article | 10/4/2014 |
| DLK-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures. | Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.
Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, Weimer RM, Kirkpatrick DS, Lewcock JW., Free PMC Article | 01/25/2014 |
| Abundance of DLK in turn controlled the levels of downstream JNK signaling and apoptosis. | JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.
Huntwork-Rodriguez S, Wang B, Watkins T, Ghosh AS, Pozniak CD, Bustos D, Newton K, Kirkpatrick DS, Lewcock JW., Free PMC Article | 11/2/2013 |
| The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK is an essential upstream mediator of both of these divergent outcomes in the same cell type. | DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW., Free PMC Article | 05/4/2013 |
| DLK is required for RGC JNK activation and cell death in a rodent model of optic neuropathy | Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ., Free PMC Article | 05/4/2013 |
| These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program. | Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.
Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A., Free PMC Article | 09/15/2012 |
| The mixed lineage kinase dual leucine zipper kinase (DLK) selectively regulates the JNK-based stress response pathway to mediate axon degeneration and neuronal apoptosis without influencing other aspects of JNK signaling. | DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW., Free PMC Article | 01/28/2012 |
| ZPK/DLK plays a critical role in naturally occurring programmed cell death of motoneurons. | ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons.
Itoh A, Horiuchi M, Wakayama K, Xu J, Bannerman P, Pleasure D, Itoh T., Free PMC Article | 07/23/2011 |
| This study indicated that the DLK-JNK pathway facilitates axon formation in neocortical neurons via stage-specific regulation of microtubule stability. | Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway.
Hirai S, Banba Y, Satake T, Ohno S., Free PMC Article | 06/25/2011 |
| Src-dependent tyrosine phosphorylation of endogenous DLK may be important for regulation of its activity. DLK may have a role in PDGF signaling. | The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF).
Daviau A, Di Fruscio M, Blouin R. | 01/21/2010 |
| These results indicate that ZPK/DLK is involved in regenerative responses of mammalian dorsal root ganglion neurons to axonal injury through activation of c-JUN. | Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.
Itoh A, Horiuchi M, Bannerman P, Pleasure D, Itoh T. | 01/21/2010 |
| Activation of Map3k12 and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A is reported. | Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A.
Plaumann S, Blume R, Börchers S, Steinfelder HJ, Knepel W, Oetjen E. | 01/21/2010 |
| Hepatic progenitors from DLK+ hepatocytes were maintained in long-term culture. | Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts.
Tanimizu N, Saito H, Mostov K, Miyajima A. | 01/21/2010 |