| MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells. | MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells.
Ha AT, Cho JY, Kim D., Free PMC Article | 10/1/2022 |
| Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. | Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function.
Liu PW, Martin GL, Lin W, Huang W, Pande S, Aronovitz MJ, Davis RJ, Blanton RM., Free PMC Article | 09/17/2022 |
| Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis. | Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis.
Chen X, Qi G, Fang F, Miao Y, Wang L. | 05/28/2022 |
| MLK3 mediates impact of PKG1alpha on cardiac function and controls blood pressure through separate mechanisms. | MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms.
Calamaras TD, Pande S, Baumgartner RA, Kim SK, McCarthy JC, Martin GL, Tam K, McLaughlin AL, Wang GR, Aronovitz MJ, Lin W, Aguirre JI, Baca P, Liu P, Richards DA, Davis RJ, Karas RH, Jaffe IZ, Blanton RM., Free PMC Article | 03/19/2022 |
| Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders. | Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.
Zhang Y, Meng Q, Yin J, Zhang Z, Bao H, Wang X. | 04/3/2021 |
| Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. | Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L., Free PMC Article | 03/27/2021 |
| Study identified that genetic loss/inhibition of a MLK3, increases CD8+ T cell cytotoxicity via inhibition of a prolyl isomerase, Ppia, and nuclear translocation of NFATc1. The MLK3 inhibitor increased the tumor infiltration of cytotoxic T cells in an immune-competent mouse model of breast cancer and increased the cytotoxic T cell population in pan T cells isolated from breast cancer patients with metastatic disease. | Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Kumar S, Singh SK, Viswakarma N, Sondarva G, Nair RS, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O, Thatcher GRJ, Rana B, Rana A., Free PMC Article | 07/25/2020 |
| This study is the first to identify GNAI2 as a promising target for prevention of hepatic I/R-induced injury and related liver diseases | Guanine nucleotide-binding protein G(i)α2 aggravates hepatic ischemia-reperfusion injury in mice by regulating MLK3 signaling.
Sun Q, He Q, Xu J, Liu Q, Lu Y, Zhang Z, Xu X, Sun B. | 05/30/2020 |
| MLK3-/- mice exhibited baseline cardiac hypertrophy with preserved cardiac function. MLK3-/- mice subjected to chronic left ventricular pressure overload developed worsened cardiac dysfunction. | Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.
Calamaras TD, Baumgartner RA, Aronovitz MJ, McLaughlin AL, Tam K, Richards DA, Cooper CW, Li N, Baur WE, Qiao X, Wang GR, Davis RJ, Kapur NK, Karas RH, Blanton RM., Free PMC Article | 11/16/2019 |
| In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation. | Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity.
Tomita K, Kabashima A, Freeman BL, Bronk SF, Hirsova P, Ibrahim SH., Free PMC Article | 12/23/2017 |
| MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia. | MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S., Free PMC Article | 10/22/2016 |
| During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10-bearing vesicles from hepatocytes, which are chemotactic for macrophages. | Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.
Ibrahim SH, Hirsova P, Tomita K, Bronk SF, Werneburg NW, Harrison SA, Goodfellow VS, Malhi H, Gores GJ., Free PMC Article | 07/16/2016 |
| TRB3(-/-) islets show a decrease in both the amplitude and duration of cytokine-stimulated MLK3 induction and JNK activation. | Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US., Free PMC Article | 02/14/2015 |
| MLK3 limits RhoA activation and injury-induced neointima formation by binding to and inhibiting the activation of p63Rho guanine nucleotide exchange factor, a RhoA activator. | Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells.
Gadang V, Konaniah E, Hui DY, Jaeschke A., Free PMC Article | 08/30/2014 |
| Genetic or pharmacologic inhibition of MLK3 blocks fMLP-mediated motility of neutrophils both in vitro and in vivo, suggesting that MLK3 may be a therapeutic target in human diseases characterized by exuberant neutrophil migration. | MLK3 regulates fMLP-stimulated neutrophil motility.
Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S., Free PMC Article | 04/5/2014 |
| Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor. | Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O, Marker DF, Dewhurst S, Gelbard HA., Free PMC Article | 03/15/2014 |
| Data from knockout mice suggest that MLK3 plays role in saturated fatty acid-induced activation of MAP kinase signaling; MLK3 appears to be involved in pathogenesis of obesity, adipose tissue in fl ammation, insulin resistance, and fatty liver disease. | MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.
Gadang V, Kohli R, Myronovych A, Hui DY, Perez-Tilve D, Jaeschke A., Free PMC Article | 11/2/2013 |
| Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death | Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US., Free PMC Article | 04/6/2013 |
| These results reveal a novel role for MLK3 signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 may be an important target for the regulation of intestinal mucosal healing. | Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa.
Kovalenko PL, Kunovska L, Chen J, Gallo KA, Basson MD., Free PMC Article | 01/12/2013 |
| mice with a targeted deletion of Mlk3 displayed multiple skeletal defects, including dental abnormalities, deficient calvarial mineralization, and reduced bone mass | MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.
Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH., Free PMC Article | 01/7/2012 |
| MLK3 ablation does not protect against hair cell death following acoustic trauma or exposure to aminoglycoside antibiotics, suggesting that MLK3 is not the major upstream regulator of JNK-mediated hair cell death following these stresses. | Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.
Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD Jr, Dewhurst S., Free PMC Article | 03/26/2011 |
| MLK3 mediates its effects via the pseudokinase TRB3, a mammalian homolog of Drosophila Tribbles. | Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US., Free PMC Article | 08/9/2010 |
| Although, cellular and humoral immune responses were similar between wild-type and MLK3-/- hosts, the viral load in the lungs was comparatively higher in MLK3-/- mice at day 8 post-infection. | Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB., Free PMC Article | 04/12/2010 |
| Hence, our data show that the direct interaction between TRAF2 and MLK3 is required for TNF-alpha-induced activation of MLK3 and its downstream target, JNK. | TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.
Sondarva G, Kundu CN, Mehrotra S, Mishra R, Rangasamy V, Sathyanarayana P, Ray RS, Rana B, Rana A., Free PMC Article | 03/15/2010 |
| MLK3 functions to limit IKK activity, and depleting MLK3 helps protect cells from etoposide-induced cell death through activation of IKK-dependent signaling. | Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death.
Cole ET, Zhan Y, Abi Saab WF, Korchnak AC, Ashburner BP, Chadee DN., Free PMC Article | 03/1/2010 |