| Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning. | Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning.
Bjorklund GR, Rees KP, Balasubramanian K, Hewitt LT, Nishimura K, Newbern JM., Free PMC Article | 07/26/2024 |
| Arteriovenous malformation Map2k1 mutation affects vasculogenesis. | Arteriovenous malformation Map2k1 mutation affects vasculogenesis.
Sudduth CL, Smits PJ, Vivero MP, Cheng YS, Ad M, Konczyk DJ, Bischoff J, Warman ML, Greene AK., Free PMC Article | 07/12/2023 |
| Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice. | Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice.
Smits PJ, Sudduth CL, Konczyk DJ, Cheng YS, Vivero MP, Kozakewich HPW, Warman ML, Greene AK., Free PMC Article | 02/14/2023 |
| Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation. | Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation.
Houde N, Beuret L, Bonaud A, Fortier-Beaulieu SP, Truchon-Landry K, Aoidi R, Pic É, Alouche N, Rondeau V, Schlecht-Louf G, Balabanian K, Espéli M, Charron J. | 02/19/2022 |
| Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition. | Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition.
Holter MC, Hewitt LT, Nishimura KJ, Knowles SJ, Bjorklund GR, Shah S, Fry NR, Rees KP, Gupta TA, Daniels CW, Li G, Marsh S, Treiman DM, Olive MF, Anderson TR, Sanabria F, Snider WD, Newbern JM., Free PMC Article | 02/5/2022 |
| Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. | Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.
Shneider BL, Cortes-Santiago N, Schady DA, Krishnamoorthy S, Thevananther S, Rajapakshe K, Perera D, Huang S, Coarfa C., Free PMC Article | 04/3/2021 |
| MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury. | MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury.
Long ME, Gong KQ, Eddy WE, Volk JS, Morrell ED, Mikacenic C, West TE, Skerrett SJ, Charron J, Liles WC, Manicone AM., Free PMC Article | 10/24/2020 |
| ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. | ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.
Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD., Free PMC Article | 09/19/2020 |
| he Mek1(Y130C) mutation recapitulates major aspects of cardio-facio-cutaneous syndrome. | Mek1(Y130C) mice recapitulate aspects of human cardio-facio-cutaneous syndrome.
Aoidi R, Houde N, Landry-Truchon K, Holter M, Jacquet K, Charron L, Krishnaswami SR, Yu BD, Rauen KA, Bisson N, Newbern J, Charron J., Free PMC Article | 10/13/2018 |
| MEK1 does not act as a general tumor suppressor in leukemogenesis. Rather, its effects strongly depend on the genetic context (RAS versus MYC-driven leukemia) and on the cell type involved. | MEK1 is required for the development of NRAS-driven leukemia.
Nowacka JD, Baumgartner C, Pelorosso C, Roth M, Zuber J, Baccarini M., Free PMC Article | 02/17/2018 |
| data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential | Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.
Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K., Free PMC Article | 12/30/2017 |
| Cdk5 may play an important role in endoplasmic reticulum stress induced podocyte apoptosis through MEKK1/JNK pathway in diabetic nephropathy. | Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy.
Zhang Y, Gao X, Chen S, Zhao M, Chen J, Liu R, Cheng S, Qi M, Wang S, Liu W. | 12/2/2017 |
| Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC). | Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
Tsioumpekou M, Papadopoulos N, Burovic F, Heldin CH, Lennartsson J. | 12/2/2017 |
| High MEK1 expression is associated with Melanoma Metastasis. | Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis.
Young A, Ngiow SF, Madore J, Reinhardt J, Landsberg J, Chitsazan A, Rautela J, Bald T, Barkauskas DS, Ahern E, Huntington ND, Schadendorf D, Long GV, Boyle GM, Hölzel M, Scolyer RA, Smyth MJ. | 11/4/2017 |
| cartilage-specific inactivation of miR322 in mice linked the loss of miR-322 to decreased MEK1 levels and to increased RAF/MEK/ERK pathway activation. | miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage.
Bluhm B, Ehlen HWA, Holzer T, Georgieva VS, Heilig J, Pitzler L, Etich J, Bortecen T, Frie C, Probst K, Niehoff A, Belluoccio D, Van den Bergen J, Brachvogel B. | 10/28/2017 |
| fluid shear stress induces autocrine TGF-beta/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling. | Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Kunnen SJ, Leonhard WN, Semeins C, Hawinkels LJAC, Poelma C, Ten Dijke P, Bakker A, Hierck BP, Peters DJM., Free PMC Article | 09/2/2017 |
| Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/beta-catenin pathways. | Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways.
Xu P, Dang Y, Wang L, Liu X, Ren X, Gu J, Liu M, Dai X, Ye X., Free PMC Article | 08/12/2017 |
| FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation | FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells.
Lee MN, Kim JW, Oh SH, Jeong BC, Hwang YC, Koh JT., Free PMC Article | 07/22/2017 |
| REDD1 is required for normal insulin-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1, and mTOR | Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Dungan CM, Williamson DL. | 06/3/2017 |
| blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db mice | Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance.
Ueyama A, Ban N, Fukazawa M, Hirayama T, Takeda M, Yata T, Muramatsu H, Hoshino M, Yamamoto M, Matsuo M, Kawashima Y, Iwase T, Kitazawa T, Kushima Y, Yamada Y, Kawabe Y., Free PMC Article | 12/24/2016 |
| MEK1 and MEK2 can substitute for each other but a minimum amount of MEK is critical for placenta development and embryo survival | Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.
Aoidi R, Maltais A, Charron J. | 10/29/2016 |
| Aberrant phosphorylation of AKT and MEK signalling pathways was identified in cells carrying mutant huntingtin. | Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.
Bowles KR, Brooks SP, Dunnett SB, Jones L., Free PMC Article | 07/2/2016 |
| An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 pathways in response to TLR4 activation. | MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages.
Bouhamdan M, Bauerfeld C, Talreja J, Beuret L, Charron J, Samavati L., Free PMC Article | 06/4/2016 |
| Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma), inhibiting adipogenesis and disrupting ERK signaling. | Nuclear MEK1 sequesters PPARγ and bisects MEK1/ERK signaling: a non-canonical pathway of retinoic acid inhibition of adipocyte differentiation.
Dave S, Nanduri R, Dkhar HK, Bhagyaraj E, Rao A, Gupta P., Free PMC Article | 11/28/2015 |
| MEK1 is inhibited by phosphorylation at Thr-292/286 by Cdk5, ERK, and Cdk1. | Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain.
Tassin TC, Benavides DR, Plattner F, Nishi A, Bibb JA., Free PMC Article | 10/3/2015 |