| A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation. | A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation.
Knudsen TE, Hamilton WB, Proks M, Lykkegaard M, Linneberg-Agerholm M, Nielsen AV, Perera M, Malzard LL, Trusina A, Brickman JM. | 09/26/2023 |
| Esrrb guides naive pluripotent cells through the formative transcriptional programme. | Esrrb guides naive pluripotent cells through the formative transcriptional programme.
Carbognin E, Carlini V, Panariello F, Chieregato M, Guerzoni E, Benvegnù D, Perrera V, Malucelli C, Cesana M, Grimaldi A, Mutarelli M, Carissimo A, Tannenbaum E, Kugler H, Hackett JA, Cacchiarelli D, Martello G., Free PMC Article | 05/17/2023 |
| ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control. | ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
Khan MN, Cherukuri P, Negro F, Rajput A, Fabrowski P, Bansal V, Lancelin C, Lee TI, Bian Y, Mayer WP, Akay T, Müller D, Bonn S, Farina D, Marquardt T., Free PMC Article | 01/14/2023 |
| The combined action of Esrrb and Nr5a2 is essential for murine naive pluripotency. | The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.
Festuccia N, Owens N, Chervova A, Dubois A, Navarro P., Free PMC Article | 11/6/2021 |
| Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci. | Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci.
Hayakawa K, Tanaka S. | 09/18/2021 |
| ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia. | ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia.
Gallagher KM, Roderick JE, Tan SH, Tan TK, Murphy L, Yu J, Li R, O'Connor KW, Zhu J, Green MR, Sanda T, Kelliher MA., Free PMC Article | 05/22/2021 |
| Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. | Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.
Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Schöler HR, Leidel SA, Bedzhov I., Free PMC Article | 11/21/2020 |
| findings provide a better understanding of the molecular mechanism of Esrrb in maintaining Trophoblast stem cells (TSCs) self-renewal and during iTSC reprogramming. | Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs.
Gao H, Gao R, Zhang L, Xiu W, Zang R, Wang H, Zhang Y, Chen J, Gao Y, Gao S., Free PMC Article | 07/18/2020 |
| Estrogen related receptor beta (ESRRB) regulates the activity of embryonic stem cell (ESC)-specific enhancer units. The developmentally regulated silencing of ESRRB triggers the selective inactivation of these units within super-enhancers (SEs). | Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency.
Bell E, Curry EW, Megchelenbrink W, Jouneau L, Brochard V, Tomaz RA, Mau KHT, Atlasi Y, de Souza RA, Marks H, Stunnenberg HG, Jouneau A, Azuara V., Free PMC Article | 05/30/2020 |
| Esrrb functions as an upstream factor of Bmp4 in the ExE, regulating proper primordial germ cell development in mice | Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.
Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J. | 05/16/2020 |
| Data show that estrogen related receptor, beta protein (ESRRB) O-GlcNAcylation is important for mouse embryonic stem cells (mESCs) self-renewal and pluripotency. | Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.
Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X., Free PMC Article | 01/4/2020 |
| Esrrb extinction triggers dismantling of naive pluripotency and marks commitment to differentiation. | Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation.
Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I., Free PMC Article | 10/5/2019 |
| Restoration of a polymorphic ESRRB motif using CRISPR-Cas9 in a hybrid ESC line restores ESRRB binding and enhancer H3K27ac in an allele-specific manner but has no effect on chromatin interactions | Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency.
Atlasi Y, Megchelenbrink W, Peng T, Habibi E, Joshi O, Wang SY, Wang C, Logie C, Poser I, Marks H, Stunnenberg HG. | 07/6/2019 |
| Esrrb activity at crucial regulatory elements of the pluripotency network, coupled with its role as a mitotic bookmarking factor and the ability to reset cellular metabolism, might explain its potent functions in ensuring the stability of pluripotency and driving the late stages of reprogramming. | Esrrb, an estrogen-related receptor involved in early development, pluripotency, and reprogramming.
Festuccia N, Owens N, Navarro P. | 01/26/2019 |
| The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. | Naive-like ESRRB(+) iPSCs with the Capacity for Rapid Neural Differentiation.
Kisa F, Shiozawa S, Oda K, Yoshimatsu S, Nakamura M, Koya I, Kawai K, Suzuki S, Okano H., Free PMC Article | 07/21/2018 |
| When transduced with Oct4, Sox2, and Klf4 (OSK) into murine fibroblasts, Zic3 and Esrrb synergistically enhance the reprogramming efficiency by regulating cellular metabolic pathways. | Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T. | 02/24/2018 |
| Taken together these observations suggest that ESRRbeta is a critical component in the onset of Ddilated cardiomyopathy by affecting contractility and calcium balance | Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ.
Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z., Free PMC Article | 07/29/2017 |
| Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells. | Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.
Uranishi K, Akagi T, Koide H, Yokota T. | 06/24/2017 |
| mitotic Esrrb binding is highly dynamic, driven by specific recognition of its DNA-binding motif and is associated with early transcriptional activation of target genes after completion of mitosis | Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.
Festuccia N, Dubois A, Vandormael-Pournin S, Gallego Tejeda E, Mouren A, Bessonnard S, Mueller F, Proux C, Cohen-Tannoudji M, Navarro P. | 05/27/2017 |
| JARID2 physically interacts with ESRRB, SALL4A, and PRDM14 | Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Sugiyama F, Yagami K, Takahashi S, Okuda A, Okazaki Y. | 11/5/2016 |
| interacts in trophoblast stem cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex | Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Latos PA, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M., Free PMC Article | 05/14/2016 |
| The forced expression of Essrb (and Nanog) resulted in the dispensability of nucleostemin expression in embryonic stem cells. | Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A., Free PMC Article | 01/16/2016 |
| Daily regulation of Esrrb in photoreceptor cells may contribute to their adaptation to 24-h changes in metabolic demands. | Photoreceptor cells display a daily rhythm in the orphan receptor Esrrβ.
Kunst S, Wolloscheck T, Grether M, Trunsch P, Wolfrum U, Spessert R., Free PMC Article | 09/12/2015 |
| Loss of Errbeta affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice. | Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Byerly MS, Swanson RD, Wong GW, Blackshaw S., Free PMC Article | 05/31/2014 |
| Esrrb selective deletion in the hindbrain alters neuropeptide Y expression, whole-body energy level and ingestive behavior. | Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.
Byerly MS, Al Salayta M, Swanson RD, Kwon K, Peterson JM, Wei Z, Aja S, Moran TH, Blackshaw S, Wong GW., Free PMC Article | 09/28/2013 |