| Loss of CEACAM1 in hepatocytes causes hepatic fibrosis. | Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Zaidi S, Asalla S, Muturi HT, Russo L, Abdolahipour R, Belew GD, Iglesias MB, Feraudo M, Leon L, Kuo E, Liu X, Kumarasamy S, Ghadieh HE, Gatto-Weis C, Zarrinpar A, Duarte S, Najjar SM., Free PMC Article | 10/11/2024 |
| Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation. | Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.
Muturi HT, Ghadieh HE, Asalla S, Lester SG, Belew GD, Zaidi S, Abdolahipour R, Shrestha AP, Portuphy AO, Stankus HL, Helal RA, Verhulst S, Duarte S, Zarrinpar A, van Grunsven LA, Friedman SL, Schwabe RF, Hinds TD Jr, Kumarasamy S, Najjar SM., Free PMC Article | 09/24/2024 |
| Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha enhances tolerance to hepatic ischemia in mice and humans. | Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW., Free PMC Article | 08/4/2023 |
| Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. | Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
Muturi HT, Ghadieh HE, Abdolahipour R, Stankus HL, Belew GD, Liu JK, Jahromi MS, Lee AD, Singer BB, Angeli-Pahim I, Sehrawat TS, Malhi H, Verhulst S, van Grunsven LA, Zarrinpar A, Duarte S, Najjar SM., Free PMC Article | 06/26/2023 |
| Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation. | Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation.
Hirao H, Kojima H, Dery KJ, Nakamura K, Kadono K, Zhai Y, Farmer DG, Kaldas FM, Kupiec-Weglinski JW., Free PMC Article | 02/11/2023 |
| Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4. | Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
Kuriri FA, Burchall G, Alanazi F, Antonipillai J, Dobie G, Beachemin N, Jackson DE. | 07/9/2022 |
| Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. | Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36.
Chean J, Chen CJ, Gugiu G, Wong P, Cha S, Li H, Nguyen T, Bhatticharya S, Shively JE., Free PMC Article | 12/18/2021 |
| Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1. | Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1.
Muturi HT, Khuder SS, Ghadieh HE, Esakov EL, Noh H, Kang H, McInerney MF, Kim JK, Lee AD, Najjar SM., Free PMC Article | 11/22/2021 |
| Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1. | Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1.
Helal RA, Russo L, Ghadieh HE, Muturi HT, Asalla S, Lee AD, Gatto-Weis C, Najjar SM., Free PMC Article | 10/9/2021 |
| CEACAM1 regulates CD8(+) T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis. | CEACAM1 regulates CD8(+) T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis.
Zöller J, Ebel JF, Khairnar V, Schmitt V, Klopfleisch R, Meiners J, Seiffart V, Hansen W, Buer J, Singer BB, Lang KS, Westendorf AM., Free PMC Article | 09/18/2021 |
| CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. | CEACAM1 specifically suppresses B cell receptor signaling-mediated activation.
Tsugawa N, Yamada D, Watabe T, Onizawa M, Wang S, Nemoto Y, Oshima S, Tsubata T, Adachi T, Kawano Y, Watanabe M, Blumberg RS, Okamoto R, Nagaishi T., Free PMC Article | 04/24/2021 |
| Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury. | Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury.
Nakamura K, Kageyama S, Kaldas FM, Hirao H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, Kujawski M, Busuttil RW, Reed EF, Kupiec-Weglinski JW., Free PMC Article | 02/6/2021 |
| Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma. | Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma.
Rayes RF, Vourtzoumis P, Bou Rjeily M, Seth R, Bourdeau F, Giannias B, Berube J, Huang YH, Rousseau S, Camilleri-Broet S, Blumberg RS, Beauchemin N, Najmeh S, Cools-Lartigue J, Spicer JD, Ferri LE., Free PMC Article | 01/2/2021 |
| the combined loss of Ceacam1 and Pten advanced prostate cancer by increasing lipogenesis and modifying the STAT3-dependent inflammatory microenvironment of prostate | Loss of Ceacam1 promotes prostate cancer progression in Pten haploinsufficient male mice.
Liu J, Muturi HT, Khuder SS, Helal RA, Ghadieh HE, Ramakrishnan SK, Kaw MK, Lester SG, Al-Khudhair A, Conran PB, Chin KV, Gatto-Weis C, Najjar SM., Free PMC Article | 08/12/2020 |
| CEACAM1 negatively regulates RP105 signaling in monocytes by recruitment of SHP-1, resulting in the sequestration of pVAV1 and beta-actin from RP105. This novel pathway and regulation of IL-6 signaling by CEACAM1 defines a novel role for monocytes in the fever response of mice to LPS | CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, Shively JE., Free PMC Article | 08/3/2019 |
| Study using NLRC5 deficient mice found that NLRC5 exacerbated renal injury by the development of postischemic renal inflammation and the induction of tubular epithelial cell apoptosis that was associated with, at least in part, the negative regulation of CEACAM1. This suggests that NLRC5 signaling in renal parenchymal cells plays the dominant role in mediating renal damage. | NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen-related cell adhesion molecule 1 signaling.
Li Q, Wang Z, Zhang Y, Zhu J, Li L, Wang X, Cui X, Sun Y, Tang W, Gao C, Ma C, Yi F. | 06/8/2019 |
| In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis. | CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor.
Zhang Z, Long C, Li X, Xie Q, Song M, Zhang Y., Free PMC Article | 06/1/2019 |
| these results identify a crucial role for CEACAM1 in endothelial homeostasis of adult blood vessels. | Endothelial barrier function is differentially regulated by CEACAM1-mediated signaling.
Ghavampour S, Kleefeldt F, Bömmel H, Volland J, Paus A, Horst A, Pfeiffer V, Hübner S, Wagner N, Rueckschloss U, Ergün S. | 04/6/2019 |
| Liver-specific rescuing of Ceacam1 reversed endothelial and cardiac dysfunction in Cc1-/-liver+ mice. | Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene.
Russo L, Muturi HT, Ghadieh HE, Wisniewski AM, Morgan EE, Quadri SS, Landesberg GP, Siragy HM, Vazquez G, Scalia R, Gupta R, Najjar SM., Free PMC Article | 03/9/2019 |
| Study concludes that CEACAM1 is an important regulator of virus-specific CD8+ T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8+ T cells. | CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection.
Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS., Free PMC Article | 01/19/2019 |
| regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction | Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.
Horst AK, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G. | 12/29/2018 |
| CEACAM1 controls epithelial-mesenchymal transition in vitro and in vivo by site-specific regulation of beta-catenin phosphorylation | CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo.
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst AK., Free PMC Article | 04/7/2018 |
| A 30-day high fat feeding regimen demonstrated that white adipose tissue-derived fatty acids repressed hepatic CEACAM1-dependent regulation of insulin and lipid metabolism in 3-month-old male C57BL/6J mice. | Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis.
Russo L, Ghadieh HE, Ghanem SS, Al-Share QY, Smiley ZN, Gatto-Weis C, Esakov EL, McInerney MF, Heinrich G, Tong X, Yin L, Najjar SM., Free PMC Article | 08/19/2017 |
| determined the crystal structure of mCEACAM1b and identified the structural differences and additional residue differences between mCEACAM1a and mCEACAM1b that affect MHV binding and entry | Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor.
Peng G, Yang Y, Pasquarella JR, Xu L, Qian Z, Holmes KV, Li F., Free PMC Article | 07/8/2017 |
| REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation | The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis.
Rueckschloss U, Kuerten S, Ergün S. | 06/24/2017 |