| CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation. | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
Chang H, Hou P, Wang X, Xiang A, Wu H, Qi W, Yang R, Wang X, Li X, He W, Zhao G, Sun W, Wang T, He DC, Wang H, Gao Y, He H., | 12/4/2023 |
| CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. | CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG., Free PMC Article | 02/19/2022 |
| CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD. | CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
Cerny O, Godlee C, Tocci R, Cross NE, Shi H, Williamson JC, Alix E, Lehner PJ, Holden DW., Free PMC Article | 10/23/2021 |
| How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse. | How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.
Hofmann F, Thalheim T, Rother K, Quaas M, Kerner C, Przybilla J, Aust G, Galle J., Free PMC Article | 08/7/2021 |
| These findings demonstrate that CD97 is a positive regulator of osteoclast-like cell differentiation, a mechanism that influences bone homeostasis. However, the presence of CD97 may be essential to suppress the initial osteoclastogenesis that occurs in response to acute and local inflammatory stimuli. | Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo.
Yeon Won H, Hwan Mun S, Shin B, Lee SK., Free PMC Article | 07/8/2017 |
| We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function | Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.
Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, Ruffert H, Glasmacher S, Hepp P, Punkt K, Neuhaus J, Hamann J, Aust G., Free PMC Article | 10/17/2015 |
| Intestinal enlargement by CD97 requires its seven-span transmembrane/cytoplasmic C-terminal fragment. | Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.
Aust G, Kerner C, Gonsior S, Sittig D, Schneider H, Buske P, Scholz M, Dietrich N, Oldenburg S, Karpus ON, Galle J, Amasheh S, Hamann J., Free PMC Article | 02/8/2014 |
| CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces. | Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Karpus ON, Veninga H, Hoek RM, Flierman D, van Buul JD, Vandenakker CC, vanBavel E, Medof ME, van Lier RA, Reedquist KA, Hamann J. | 05/25/2013 |
| Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial. | Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
Hoek RM, de Launay D, Kop EN, Yilmaz-Elis AS, Lin F, Reedquist KA, Verbeek JS, Medof ME, Tak PP, Hamann J. | 05/10/2010 |
| Despite the broad expression pattern of wild-type murine CD97, the successfully deleted gene Cd97-deficient mouse that is created has no overt phenotype, except for a mild granulocytosis that is normal in the absence of CD97. | Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
Veninga H, Becker S, Hoek RM, Wobus M, Wandel E, van der Kaa J, van der Valk M, de Vos AF, Haase H, Owens B, van der Poll T, van Lier RA, Verbeek JS, Aust G, Hamann J. | 01/21/2010 |
| In BALB/c mice, CD97 expression can be applied to almost completely separate colony-forming cells and cells exhibiting radioprotective capacity. | CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells.
van Pel M, Hagoort H, Hamann J, Fibbe WE. | 01/21/2010 |
| Mobilization was absent and neutrophils were reduced in mice receiving CD97 mAb plus interleukin-8, while granulocyte-colony stimulating factor-induced mobilization remained unaltered by anti-CD97. CD97 has a role in IL-8 induced HSC/HPC mobilization. | Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization.
van Pel M, Hagoort H, Kwakkenbos MJ, Hamann J, Fibbe WE. | 01/21/2010 |
| CD97 plays a role in peripheral granulocyte homeostasis by functioning in an adhesive capacity. | Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.
Wang T, Tian L, Haino M, Gao JL, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, Kelly K., Free PMC Article | 01/21/2010 |
| In vivo findings in experimental colitis and pneumococcal pneumonia indicate an essential role for CD97 in the migration of neutrophils. | The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.
Leemans JC, te Velde AA, Florquin S, Bennink RJ, de Bruin K, van Lier RA, van der Poll T, Hamann J. | 01/21/2010 |