| ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2. | ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2.
Yang F, Chen M, Liu Y, Hu Y, Chen Y, Yu Y, Deng L., Free PMC Article | 07/19/2024 |
| ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion. | ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
Kadomatsu T, Hara C, Kurahashi R, Horiguchi H, Morinaga J, Miyata K, Kurano S, Kanemaru H, Fukushima S, Araki K, Baba M, Linehan WM, Kamba T, Oike Y., Free PMC Article | 12/15/2023 |
| ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. | ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
Horiguchi H, Kadomatsu T, Yamashita T, Yumoto S, Terada K, Sato M, Morinaga J, Miyata K, Oike Y., Free PMC Article | 09/28/2023 |
| ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway. | ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
Li J, Wan T, Liu C, Liu H, Ke D, Li L. | 09/27/2023 |
| ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway. | ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
Huang X, Su Z, Zhang S, Xu X, Yang B, Xu X., Free PMC Article | 03/7/2023 |
| Angiopoietin-like 2 is essential to aortic valve development in mice. | Angiopoietin-like 2 is essential to aortic valve development in mice.
Labbé P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin É., Free PMC Article | 11/26/2022 |
| Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis. | Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.
Horiguchi H, Kadomatsu T, Yumoto S, Masuda T, Miyata K, Yamamura S, Sato M, Morinaga J, Ohtsuki S, Baba H, Moroishi T, Oike Y. | 08/20/2022 |
| Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2. | Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
Yang J, Shen G, Cao J, Zhang J, Gu Y, Zhang X, Jiang X, Luo M, Lu Z. | 06/25/2022 |
| Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches. | Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
Yu Z, Yang W, He X, Chen C, Li W, Zhao L, Liu L, Liu J, Xie L, Zhang Y, Zheng J., Free PMC Article | 04/23/2022 |
| ANGPTL2 Promotes Inflammation via Integrin alpha5beta1 in Chondrocytes. | ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes.
Takano M, Hirose N, Sumi C, Yanoshita M, Nishiyama S, Onishi A, Asakawa Y, Tanimoto K., Free PMC Article | 04/9/2022 |
| ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. | ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression.
Huang D, Sun G, Hao X, He X, Zheng Z, Chen C, Yu Z, Xie L, Ma S, Liu L, Zhou BO, Cheng H, Zheng J, Cheng T., Free PMC Article | 09/11/2021 |
| Foxc2 Alleviates Ox-LDL-Induced Lipid Accumulation, Inflammation, and Apoptosis of Macrophage via Regulating the Expression of Angptl2. | Foxc2 Alleviates Ox-LDL-Induced Lipid Accumulation, Inflammation, and Apoptosis of Macrophage via Regulating the Expression of Angptl2.
Yang L, Li T, Zha L. | 06/12/2021 |
| Our data suggest that therapeutic down-regulation of vascular angptl2 leads to the clearance of SnEC by apoptosis, stimulates endothelial repair and reduces atherosclerosis. | Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice.
Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É., Free PMC Article | 07/18/2020 |
| ANGPTL2 deficiency in tumor stroma accelerates tumor progression | Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.
Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan WM, Moroishi T, Oike Y., Free PMC Article | 12/21/2019 |
| Circulating ANGPTL2 levels increase in mice with heart failure. Increased circulating ANGPTL2 levels in mice reflect, rather than promote, cardiac dysfunction. | Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction.
Tian Z, Miyata K, Morinaga J, Horiguchi H, Kadomatsu T, Endo M, Zhao J, Zhu S, Sugizaki T, Sato M, Terada K, Okumura T, Murohara T, Oike Y. | 02/23/2019 |
| The ANGPTL2 played an essential role in osteoclast generation through regulating the proliferation and inflammation of osteoclast lineage cells, providing new insights into the therapeutic strategy to alleviate bone loss. | ANGPTL2 deletion inhibits osteoclast generation by modulating NF-κB/MAPKs/Cyclin pathways.
Li WM, Han CL, Liu C, Xing HY, Ding DC. | 02/16/2019 |
| ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia. | Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y., Free PMC Article | 12/1/2018 |
| Angptl2(-/-) in paraquat-treated mice attenuated acute lung injury progression by reducing the number of total cells, total leukocytes, neutrophils and macrophages in bronchoalveolar lavage fluid and reducing inflammatory response through the inactivation of nuclear factor kappa B pathway. | Angptl2 deficiency attenuates paraquat (PQ)-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis through NF-κB pathway.
Yang W, Liu W, Yu W, Fei D, Meng X, Yang S, Meng S, Zhao M. | 12/1/2018 |
| Kaempferol modulates the expression of ANGPTL2 to lessen the mastitis in mice. | Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice.
Xiao HB, Sui GG, Lu XY, Sun ZL. | 10/13/2018 |
| These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine. | ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis.
Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y., Free PMC Article | 07/15/2017 |
| we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke. | Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion.
Amadatsu T, Morinaga J, Kawano T, Terada K, Kadomatsu T, Miyata K, Endo M, Kasamo D, Kuratsu JI, Oike Y., Free PMC Article | 07/1/2017 |
| Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung. | Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.
Motokawa I, Endo M, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H, Oike Y. | 06/3/2017 |
| Angptl2 regulates not only adipose tissue metabolism but also bone metabolism | Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.
Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F. | 05/27/2017 |
| findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection. | Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.
Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y., Free PMC Article | 05/20/2017 |
| Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration. | Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.
Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y., Free PMC Article | 08/20/2016 |