| ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair. | A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons.
Leighton LJ, Zhao Q, Li X, Dai C, Marshall PR, Liu S, Wang Y, Zajaczkowski EL, Khandelwal N, Kumar A, Bredy TW, Wei W., Free PMC Article | 02/23/2019 |
| Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. | A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. | 10/28/2017 |
| ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta/delta. | Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation.
Qu B, Hong Z, Gong K, Sheng J, Wu HH, Deng SL, Huang G, Ma ZH, Pan XM., Free PMC Article | 08/6/2016 |
| Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1. | Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
Menéndez C, Adrados I, Fernández-Barral A, Jiménez B, Flores JM, Cañamero M, Fuchtbauer EM, Beermann F, Palmero I. | 02/14/2015 |
| Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery. | Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1.
Gómez-Cabello D, Callejas S, Benguría A, Moreno A, Alonso J, Palmero I. | 04/12/2010 |
| Analysis of marker gene expression in p37(Ing1b)/p53 null tumors indicates that the double-null mice develop both nongerminal center and germinal center B-cell-like DLBL. | p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.
Coles AH, Marfella CG, Imbalzano AN, Steinman HA, Garlick DS, Gerstein RM, Jones SN., Free PMC Article | 01/21/2010 |
| A more sophisticated approach, using neural networks, permits prediction of interaction among three or more genes (p53, bax, and ING1). | Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation.
Duan S, Wan L, Fu WJ, Pan H, Ding Q, Chen C, Han P, Zhu X, Du L, Liu H, Chen Y, Liu X, Yan X, Deng M, Qian M. | 01/21/2010 |
| important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 activation and as a regulator of chromatin remodeling processes. | Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress.
Abad M, Menéndez C, Füchtbauer A, Serrano M, Füchtbauer EM, Palmero I. | 01/21/2010 |
| p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner. | Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
Coles AH, Liang H, Zhu Z, Marfella CG, Kang J, Imbalzano AN, Jones SN., Free PMC Article | 01/21/2010 |
| p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras | Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
Goeman F, Thormeyer D, Abad M, Serrano M, Schmidt O, Palmero I, Baniahmad A., Free PMC Article | 01/21/2010 |
| the suggested role of ing1 as a candidate tumor suppressor gene involved in control of DNA damage response. | Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas.
Kichina JV, Zeremski M, Aris L, Gurova KV, Walker E, Franks R, Nikitin AY, Kiyokawa H, Gudkov AV. | 01/21/2010 |
| Characterization of nuclear localization signal in mouse ING1 homolog protein. | Characterization of nuclear localization signal in mouse ING1 homolog protein.
Ha S, Park S, Yun CH, Choi Y. | 01/21/2010 |
| Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG | Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.
Takahashi M, Seki N, Ozaki T, Kato M, Kuno T, Nakagawa T, Watanabe K, Miyazaki K, Ohira M, Hayashi S, Hosoda M, Tokita H, Mizuguchi H, Hayakawa T, Todo S, Nakagawara A. | 01/21/2010 |