| SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression. | SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression.
Ma YN, Zou YD, Liu ZL, Wu GX, Zhou YZ, Luo CX, Huang XT, Xie ML, Xu SN, Li X. | 02/27/2024 |
| SENP3 mediates the activation of the Wnt/beta-catenin signaling pathway to accelerate the growth and metastasis of oesophagal squamous cell carcinoma in mice. | SENP3 mediates the activation of the Wnt/β-catenin signaling pathway to accelerate the growth and metastasis of oesophagal squamous cell carcinoma in mice.
Wang P, Yang L, Guo Y, Qi S, Liang J, Tian G, Tian Z. | 02/26/2024 |
| SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma metastasis via deSUMOylating DKC1. | SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma metastasis via deSUMOylating DKC1.
Wu X, Li JH, Xu L, Li YX, Zhu XX, Wang XY, Wu X, Zhao W, Ni X, Yin XY., Free PMC Article | 06/30/2023 |
| Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage. | Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage.
Bao X, Liu B, Jiang Y, Feng T, Cao W, Shi J, Jiang Y, Chen X, Yang J, Li J, Zhou Z., Free PMC Article | 02/28/2023 |
| SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3. | SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3.
Li Z, Liu J, Fu H, Li Y, Liu Q, Song W, Zeng M., Free PMC Article | 10/29/2022 |
| Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin. | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W., Free PMC Article | 10/1/2022 |
| Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1. | Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1.
Wilkinson KA, Guo C., Free PMC Article | 07/23/2022 |
| SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells. | SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells.
Nishida T. | 06/25/2022 |
| High SENP3 Expression Promotes Cell Migration, Invasion, and Proliferation by Modulating DNA Methylation of E-Cadherin in Osteosarcoma. | High SENP3 Expression Promotes Cell Migration, Invasion, and Proliferation by Modulating DNA Methylation of E-Cadherin in Osteosarcoma.
Yang P, Liu Y, Qi YC, Lian ZH., Free PMC Article | 11/27/2021 |
| SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A. | SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
Yu B, Lin Q, Huang C, Zhang B, Wang Y, Jiang Q, Zhang C, Yi J. | 07/31/2021 |
| Combined identification of ARID1A, CSMD1, and SENP3 as effective prognostic biomarkers for hepatocellular carcinoma. | Combined identification of ARID1A, CSMD1, and SENP3 as effective prognostic biomarkers for hepatocellular carcinoma.
Zhao Y, Yang B, Chen D, Zhou X, Wang M, Jiang J, Wei L, Chen Z., Free PMC Article | 07/24/2021 |
| SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. | SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes.
Zhang Y, Yang K, Yang J, Lao Y, Deng L, Deng G, Yi J, Sun X, Wang Q. | 03/13/2021 |
| SUMO1-catalyzed SUMOylation and SENP3-mediated deSUMOylation of NLRP3 orchestrate the inflammasome activation. | SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation.
Shao L, Liu Y, Wang W, Li A, Wan P, Liu W, Shereen MA, Liu F, Zhang W, Tan Q, Wu K, Liu Y, Wu J. | 07/11/2020 |
| Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC] | Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB., Free PMC Article | 02/28/2020 |
| we performed ischemia and ischemia-reperfusion experiments in the cardiomyocyte H9C2 cell line. Similar to whole hearts, ischemia induced a decrease in cytosolic SENP3. Furthermore, shRNA-mediated knockdown of SENP3 led to an increase in the rate of cell death upon reperfusion. | Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury.
Rawlings N, Lee L, Nakamura Y, Wilkinson KA, Henley JM., Free PMC Article | 12/21/2019 |
| SENP3 expression level decreased in HBV-infected hepatocytes in various models including HepG2-NTCP cell lines and a humanized mouse model. Downregulation of SENP3 reduced HBV replication and boosted host protein translation. | SENP3-mediated host defense response contains HBV replication and restores protein synthesis.
Xi R, Kadur Lakshminarasimha Murthy P, Tung KL, Guy CD, Wan J, Li F, Wang Z, Li X, Varanko A, Rakhilin N, Xin Y, Liu B, Qian SB, Su L, Han Y, Shen X., Free PMC Article | 10/5/2019 |
| we provide the first direct evidence that SENP3 upregulation pivotally contributes to myocardial ischemia reperfusion (MIR) injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury.
Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, Ji Q, Tong R, Fu Y, Gao Y, Su Y, Yuan A, He B, Pu J. | 06/22/2019 |
| SENP3 phosphorylation decreased its interaction with Topo II alpha, resulting in reduced SENP3 deSUMOylation activity on Topo II alpha. Furthermore, we observed mitotic arrest, increased chromosome instability, and promotion of tumorigenesis in cells expressing a nonphosphorylatable SENP3 mutant | Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.
Wei B, Huang C, Liu B, Wang Y, Xia N, Fan Q, Chen GQ, Cheng J. | 05/18/2019 |
| Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. | SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death.
Guo C, Wilkinson KA, Evans AJ, Rubin PP, Henley JM., Free PMC Article | 12/1/2018 |
| Important role of SENP3 in lipid metabolism during the development of non-alcoholic fatty liver disease. | SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease.
Liu Y, Yu F, Han Y, Li Q, Cao Z, Xiang X, Jiang S, Wang X, Lu J, Lai R, Wang H, Cai W, Bao S, Xie Q., Free PMC Article | 06/2/2018 |
| SENP3 knockdown reduced cadmium-induced caspase 3 cleavage and cell death in PC12 cells, while SENP3 overexpression enhanced cell death. | Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity.
Luo J, Gurung S, Lee L, Henley JM, Wilkinson KA, Guo C. | 10/7/2017 |
| Our data identified SUMOylation as a previously undescribed post-translational modification of STAT3 and SENP3 as a critical positive modulator of tobacco- or cytokine-induced STAT3 activation. | SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.
Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J., Free PMC Article | 09/9/2017 |
| The data demonstrate that SUMO2 conjugation and SENP3-driven deSUMOylation of PELP1 is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation. | The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.
Raman N, Weir E, Müller S. | 09/2/2017 |
| our findings for the first time specifically supported that SUMO-specific protease 3 might play an important role in the regulation of epithelial ovarian cancer progression and could serve as a potential biomarker for prognosis as well as provide a promising therapeutic target against epithelial ovarian cancer | Upregulation of SENP3/SMT3IP1 promotes epithelial ovarian cancer progression and forecasts poor prognosis.
Cheng J, Su M, Jin Y, Xi Q, Deng Y, Chen J, Wang W, Chen Y, Chen L, Shi N, Mao G. | 04/8/2017 |
| In early-onset pre-eclampsia, enhanced deSUMOylation of HIF1A by SENP3 may in part contribute to increased HIF1A activity and stability found in this pathology. | Dynamic regulation of HIF1Α stability by SUMO2/3 and SENP3 in the human placenta.
Bhattacharjee J, Alahari S, Sallais J, Tagliaferro A, Post M, Caniggia I. | 01/14/2017 |