| Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting. | Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.
Doray B, Liu L, Lee WS, Jennings BC, Kornfeld S., Free PMC Article | 12/18/2021 |
| The adaptor, GGA1, and retromer are essential to mediate rapid trafficking of phosphorylated BACE1 to recycling endosomes. Therefore, post-translational phosphorylation of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer, which is important in regulating amyloid beta production. | GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.
Toh WH, Chia PZC, Hossain MI, Gleeson PA., Free PMC Article | 01/12/2019 |
| full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. | Regulation of α(2B)-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.
Zhang M, Huang W, Gao J, Terry AV, Wu G., Free PMC Article | 06/2/2018 |
| These findings show that the AD-like phenotype of NPC model cells can be partly reverted by promoting a non-amyloidogenic processing of APP through the upregulation of GGA1 supporting its preventive role against AD | GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells.
Kosicek M, Wunderlich P, Walter J, Hecimovic S. | 09/27/2014 |
| These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. | Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.
Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V., Free PMC Article | 04/26/2014 |
| On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment | GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production.
Herskowitz JH, Offe K, Deshpande A, Kahn RA, Levey AI, Lah JJ., Free PMC Article | 12/22/2012 |
| GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. | Defects in cellular sorting and retroviral assembly induced by GGA overexpression.
Joshi A, Nagashima K, Freed EO., Free PMC Article | 01/21/2010 |
| p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers. | The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.
Mardones GA, Burgos PV, Brooks DA, Parkinson-Lawrence E, Mattera R, Bonifacino JS., Free PMC Article | 01/21/2010 |
| These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. | PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.
Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL., Free PMC Article | 01/21/2010 |
| A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5. | The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle.
Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. | 01/21/2010 |
| Our data indicate that GGA proteins are not only involved in the sorting at the TGN but also mediate the retrograde transport of cargo proteins from endosomes to the TGN. | GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J. | 01/21/2010 |
| endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 | Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
He X, Chang WP, Koelsch G, Tang J. | 01/21/2010 |
| GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. | GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT., Free PMC Article | 01/21/2010 |
| X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain | Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.
Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S. | 01/21/2010 |
| X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence | Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Shiba T, Takatsu H, Nogi T, Matsugaki N, Kawasaki M, Igarashi N, Suzuki M, Kato R, Earnest T, Nakayama K, Wakatsuki S. | 01/21/2010 |
| GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region | GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.
Bai H, Doray B, Kornfeld S. | 01/21/2010 |
| serine phosphorylation of BACE is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1 | Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT. | 01/21/2010 |
| the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles | Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles.
Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S. | 01/21/2010 |
| GGA1 alters the proteolytic processing of beta-amyloid precursor protein (APP) and the secretion of APPs and amyloid-beta, suggesting a role of GGA1 in Alzheimer's disease pathogenesis. | GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J., Free PMC Article | 01/21/2010 |
| GGA proteins funstion with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. | GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
He X, Li F, Chang WP, Tang J. | 01/21/2010 |
| Crystal structure of the human GGA1 GAT domain | Crystal structure of the human GGA1 GAT domain.
Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. | 01/21/2010 |
| The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF. | Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor.
Suer S, Misra S, Saidi LF, Hurley JH., Free PMC Article | 01/21/2010 |
| Rabaptin-5, ubiquitin, and TSG101 bind to overlapping but distinct binding sites on the trihelical bundle subdomain of GGA-1 protein | The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites.
Mattera R, Puertollano R, Smith WJ, Bonifacino JS. | 01/21/2010 |
| the interaction between the hinge region and the GAE domain underlies the autoregulation of GGA function in clathrin-mediated trafficking through competing with the accessory proteins and the AP-1 complex | Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1.
Inoue M, Shiba T, Ihara K, Yamada Y, Hirano S, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Nakayama K, Wakatsuki S. | 01/21/2010 |