TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation. | TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation. Fonódi M, Thalwieser Z, Csortos C, Boratkó A., Free PMC Article | 01/12/2024 |
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow. | The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow. Quan X, Liu X, Qin X, Wang Y, Sun T, Li Z, Zhu L, Chen J, Zhou Y, Singh S, Dong H, Zhang Z, Zhang H., Free PMC Article | 11/6/2021 |
The TIMAP inhibits myosin phosphatase activity in ECs by competing with MYPT1 for PP1cbeta and blocking the PP1cbeta active site. | TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ. Wang X, Obeidat M, Li L, Pasarj P, Aburahess S, Holmes CFB, Ballermann BJ., Free PMC Article | 04/4/2020 |
TIMAP is the versatile protein phosphatase 1 regulator in endothelial cells. (Review) | TIMAP, the versatile protein phosphatase 1 regulator in endothelial cells. Boratkó A, Csortos C. | 07/7/2018 |
NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP and EBP50 is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 = Ezrin-Radixin-Mosein binding phosphoprotein 50) | Regulation of merlin by protein phosphatase 1-TIMAP and EBP50 in endothelial cells. Boratkó A, Péter M, Csortos C. | 11/4/2017 |
phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation | PKC mediated phosphorylation of TIMAP regulates PP1c activity and endothelial barrier function. Boratkó A, Csortos C. | 06/24/2017 |
Results indicate that PKC-phosphorylated ECE-1 is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 production of EC through the regulation of ECE-1 activity. | TIMAP-protein phosphatase 1-complex controls endothelin-1 production via ECE-1 dephosphorylation. Boratkó A, Veréb Z, Petrovski G, Csortos C. | 12/24/2016 |
ROCK phosphorylated eEF1A1 is a novel substrate for TIMAP-PP1 underlining the complex regulatory role of TIMAP in the endothelium. | Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. Boratkó A, Péter M, Thalwieser Z, Kovács E, Csortos C. | 09/24/2016 |
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. | TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Obeidat M, Li L, Ballermann BJ. | 03/28/2015 |
These data confirmed the barrier-protective role of TIMAP | TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS. Poirier C, Gorshkov BA, Zemskova MA, Bogatcheva NV, Verin AD., Free PMC Article | 06/16/2012 |
Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c. | Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1. Czikora I, Kim KM, Kása A, Bécsi B, Verin AD, Gergely P, Erdodi F, Csortos C., Free PMC Article | 10/22/2011 |
involvement of TIMAP in PKA-mediated moesin dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection | TIMAP is a positive regulator of pulmonary endothelial barrier function. Csortos C, Czikora I, Bogatcheva NV, Adyshev DM, Poirier C, Olah G, Verin AD., Free PMC Article | 01/21/2010 |
TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. | TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. Cao W, Mattagajasingh SN, Xu H, Kim K, Fierlbeck W, Deng J, Lowenstein CJ, Ballermann BJ. | 01/21/2010 |