| Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase. | Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase.
Vaidyanathan D, Paskaleva E, Vargason T, Ke X, McCallum SA, Linhardt RJ, Dordick JS., Free PMC Article | 11/6/2021 |
| Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1. | Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1.
Jiang J, Zhan X, Xu G, Liang T, Yu C, Liao S, Chen L, Huang S, Sun X, Yi M, Zhang Z, Yao Y, Liu C., Free PMC Article | 07/31/2021 |
| Results found the expression of GLCE is significantly decreased in the brains of frontotemporal lobar degeneration cases relative to normal controls, demonstrating the potential disease relevance of the candidate gene identified. Furthermore, knockdown of GLCE in cultured human cells protects against oxidative stress induced pTDP accumulation. | Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.
Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Keene CD, Bird TD, Kraemer BC., Free PMC Article | 03/7/2020 |
| Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. | Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.
Debarnot C, Monneau YR, Roig-Zamboni V, Delauzun V, Le Narvor C, Richard E, Hénault J, Goulet A, Fadel F, Vivès RR, Priem B, Bonnaffé D, Lortat-Jacob H, Bourne Y., Free PMC Article | 05/25/2019 |
| Results show that overexpression of Hsepi alone resulted in an unexpected increase in heparan sulfate (HS) chain length. A Hsepi point-mutant (Y168A), devoid of catalytic activity, failed to affect chain length. Moreover, the effect of Hsepi overexpression on HS chain length was abolished by simultaneous overexpression of 2OST. | Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.
Fang J, Song T, Lindahl U, Li JP., Free PMC Article | 05/5/2018 |
| The obtained data suggest an involvement of GLCE rs3865014 in breast cancer development. Heterozygous AG genotype might be a risk factor for breast cancer susceptibility in Siberian women and is associated with aggressive ER-negative and triple-negative cancer subtypes. | GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.
Belyavskaya VA, Prudnikova TY, Domanitskaya NV, Litviakov NV, Maksimov VN, Cherdyntseva NV, Grigorieva EV. | 10/14/2017 |
| The GLCE gene polymorphism rs3865014 appears to have biological relevance in human pathophysiology. | Glucuronic Acid Epimerase (GLCE) Variant rs3865014 (A>G) Is Associated with BMI, Blood Hemoglobin, Hypertension, and Cerebrovascular Events, the TAMRISK Study.
Kunnas T, Solakivi T, Määttä K, Nikkari ST. | 06/3/2017 |
| C5-epimerase and 2-O-sulfotransferase in association generate extended domains of consecutive GlcNS-IdoA2S Sequence. | C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains.
Préchoux A, Halimi C, Simorre JP, Lortat-Jacob H, Laguri C. | 05/7/2016 |
| GLCE may be used as a potential model to study the functional role of intratumor cell heterogeneity in prostate cancer progression. | Heterogeneity of d-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer.
Prudnikova TY, Soulitzis N, Kutsenko OS, Mostovich LA, Haraldson K, Ernberg I, Kashuba VI, Spandidos DA, Zabarovsky ER, Grigorieva EV., Free PMC Article | 09/20/2014 |
| activation of angiogenesis as a main molecular mechanism of pro-oncogenic effect of GLCE in prostate cancer. | D-glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells.
Rosenberg EE, Prudnikova TY, Zabarovsky ER, Kashuba VI, Grigorieva EV. | 06/14/2014 |
| positive correlation between miRNA-218 and GLCE mRNA, and negative correlation between miRNA-218 and GLCE protein levels in breast tissues and primary tumors in vivo, supporting a direct involvement of miRNA-218 in posttranscriptional regulation of GLCE | miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues.
Prudnikova TY, Mostovich LA, Kashuba VI, Ernberg I, Zabarovsky ER, Grigorieva EV., Free PMC Article | 04/6/2013 |
| Chondroitin-glucuronate C5-epimerase is a potential candidate for tumour antigen with immunogenicity and the peptides derived from this antigen could be useful in hepatocellular carcinoma immunotherapy. | Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma.
Mizukoshi E, Fushimi K, Arai K, Yamashita T, Honda M, Kaneko S. | 02/23/2013 |
| A correlation was observed between D-glucuronyl C5-epimerase (GLCE), TCF4 and beta-catenin expression in breast cancer cells and primary tumors, suggesting an important role for TCF4/beta-catenin in regulating GLCE expression both in vitro and in vivo. | The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.
Mostovich LA, Prudnikova TY, Kondratov AG, Gubanova NV, Kharchenko OA, Kutsenko OS, Vavilov PV, Haraldson K, Kashuba VI, Ernberg I, Zabarovsky ER, Grigorieva EV., Free PMC Article | 01/26/2013 |
| The biphasic mode of C(5)-epi offers a novel mechanism to regulate the biosynthesis of HS with the desired biological functions. | Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis.
Sheng J, Xu Y, Dulaney SB, Huang X, Liu J., Free PMC Article | 08/25/2012 |
| Loss of D-glucuronyl C-5 epimerase is associated with small-cell lung cancer. | D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.
Grigorieva EV, Prudnikova TY, Domanitskaya NV, Mostovich LA, Pavlova TV, Kashuba VI, Zabarovsky ER., Free PMC Article | 09/24/2011 |
| SNPs in GLCE are associated with triglyceride and HDL-C levels in Turks, and mouse studies support a role for glce in lipid metabolism. | Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.
Hodoğlugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW., Free PMC Article | 06/18/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| in 82-84% of human breast tumors there is either downregulation or loss of D-glucuronyl C5-epimerase mRNA expression and significant decrease of the protein content | Decreased expression of human D-glucuronyl C5-epimerase in breast cancer.
Grigorieva E, Eshchenko T, Rykova VI, Chernakov A, Zabarovsky E, Sidorov SV. | 01/21/2010 |
| The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported. | The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.
Ghiselli G, Agrawal A., Free PMC Article | 01/21/2010 |