| Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis. | Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis.
Liu C, Yang J, Zhu F, Zhao Z, Gao L. | 11/5/2022 |
| SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/beta-catenin pathway. | SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/β-catenin pathway.
Li C, Wang M, Shi Y, Xin H. | 07/16/2022 |
| Impact of microRNA-21-5p on the growth of thyroid cancer cells via targeting the recombinant sclerostin domain containing protein 1.", trans "RNA-21-5p1. | Impact of microRNA-21-5p on the growth of thyroid cancer cells via targeting the recombinant sclerostin domain containing protein 1.
Liu M, Deng H, Zhao Y, Li C, Liu H., Free PMC Article | 12/25/2021 |
| Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST. | Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST.
Gipson GR, Kattamuri C, Czepnik M, Thompson TB., Free PMC Article | 02/27/2021 |
| Downregulation of Sostdc1 in Testicular Sertoli Cells is Prerequisite for Onset of Robust Spermatogenesis at Puberty. | Downregulation of Sostdc1 in Testicular Sertoli Cells is Prerequisite for Onset of Robust Spermatogenesis at Puberty.
Pradhan BS, Bhattacharya I, Sarkar R, Majumdar SS., Free PMC Article | 10/31/2020 |
| Study revealed upregulation of ADAMTS8 and downregulation of FRAS1 and SOSTDC1 in primary fibroblasts from linear morphoea (LM) lesions. SOSTDC1 knock-down recapitulated the reduced TGF -beta1 responsiveness and LM fibroblast migration, while overexpression of ADAMTS 8 induced myofibroblast markers. | Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.
Badshah II, Brown S, Weibel L, Rose A, Way B, Sebire N, Inman G, Harper J, O'Shaughnessy RFL. | 08/1/2020 |
| As rat Sostdc1 and human SOSTDC1 are dual antagonists of the Wnt/beta-catenin and BMP signaling pathways, these results underscore the potential crucial roles of these pathways and their antagonists, such as Sostdc1 and SOSTDC1, in developing and adult mammalian normal eyes as well as in syndromic and nonsyndromic congenital eye diseases. | Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes.
Valensi M, Goldman G, Marchant D, Van Den Berghe L, Jonet L, Daruich A, Robert MP, Krejci E, Klein C, Mascarelli F, Versaux-Botteri C, Moulin A, Putterman M, Guimiot F, Molina T, Terris B, Brémond-Gignac D, Behar-Cohen F, Abitbol MM. | 02/15/2020 |
| Lack of association between SOSTDC1 gene polymorphisms and mesiodens | Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens.
Liu S, Li J, Xu J, Liao S, Chen Y, Zhang R, Tian R, Zhang K., Free PMC Article | 11/23/2019 |
| The present study aimed to investigate SOSTDC1 coding regions in non-syndromic patients with one or more supernumerary teeth | Investigation of SOSTDC1 gene in non-syndromic patients with supernumerary teeth.
Arikan V, Cumaogullari O, Ozgul BM, Oz FT., Free PMC Article | 03/16/2019 |
| SOSTDC1 may be a potential prognostic biomarker and therapeutic target for nonsmall cell lung cancer bone metastasis. | SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target.
Chen G, Gong H, Wang T, Wang J, Han Z, Bai G, Han S, Yang X, Zhou W, Liu T, Xiao J., Free PMC Article | 03/2/2019 |
| findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. | SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways.
Zhou Q, Chen J, Feng J, Xu Y, Zheng W, Wang J. | 07/14/2018 |
| Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. | Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Liang W, Guan H, He X, Ke W, Xu L, Liu L, Xiao H, Li Y., Free PMC Article | 08/27/2016 |
| Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. | E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells.
Rawat A, Gopisetty G, Thangarajan R. | 09/26/2015 |
| Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer | Hepcidin regulation in prostate and its disruption in prostate cancer.
Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV., Free PMC Article | 08/22/2015 |
| Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. | Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.
Hsieh JC, Estess RC, Kaneko I, Whitfield GK, Jurutka PW, Haussler MR., Free PMC Article | 03/15/2014 |
| DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. | SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer.
Gopal G, Raja UM, Shirley S, Rajalekshmi KR, Rajkumar T. | 10/19/2013 |
| SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. | SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer.
Clausen KA, Blish KR, Birse CE, Triplette MA, Kute TE, Russell GB, D'Agostino RB Jr, Miller LD, Torti FM, Torti SV., Free PMC Article | 09/15/2012 |
| Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. | Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men.
He JW, Yue H, Hu WW, Hu YQ, Zhang ZL. | 04/28/2012 |
| genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. | Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors.
Blish KR, Clausen KA, Hawkins GA, Garvin AJ, Willingham MC, Turner JC, Torti FM, Torti SV., Free PMC Article | 03/19/2011 |
| Loss of SOSTDC1 gene is associated with Wilms tumor. | Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.
Ohshima J, Haruta M, Arai Y, Kasai F, Fujiwara Y, Ariga T, Okita H, Fukuzawa M, Hata J, Horie H, Kaneko Y. | 01/21/2010 |
| This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. | A human bone morphogenetic protein antagonist is down-regulated in renal cancer.
Blish KR, Wang W, Willingham MC, Du W, Birse CE, Krishnan SR, Brown JC, Hawkins GA, Garvin AJ, D'Agostino RB Jr, Torti FM, Torti SV., Free PMC Article | 01/21/2010 |
| USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. | USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T. | 01/21/2010 |
| Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways | Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.
Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N. | 01/21/2010 |