| Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities. | Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities.
Suzuki R, Murakami C, Dilimulati K, Atsuta-Tsunoda K, Kawai T, Sakane F. | 11/20/2023 |
| Diacylglycerol kinase zeta interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions. | Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.
Furuta M, Murakami C, Numagami Y, Suzuki R, Sakane F., Free PMC Article | 07/7/2023 |
| Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry. | Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry.
Niekamp P, Guzman G, Leier HC, Rashidfarrokhi A, Richina V, Pott F, Barisch C, Holthuis JCM, Tafesse FG., Free PMC Article | 09/4/2021 |
| Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma. | Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma.
Lu H, Zhou L, Zuo H, Le W, Hu J, Zhang T, Li M, Yuan Y. | 06/26/2021 |
| Regulation of human sphingomyelin synthase 1 translation through its 5'-untranslated region. | Regulation of human sphingomyelin synthase 1 translation through its 5'-untranslated region.
Daian F, Esper BS, Ashrafi N, Yu GQ, Luciano G, Moorthi S, Luberto C., Free PMC Article | 05/29/2021 |
| Diacylglycerol kinase delta and sphingomyelin synthase-related protein functionally interact via their sterile alpha motif domains. | Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains.
Murakami C, Hoshino F, Sakai H, Hayashi Y, Yamashita A, Sakane F., Free PMC Article | 10/24/2020 |
| Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2. | Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2.
Tachida Y, Kumagai K, Sakai S, Ando S, Yamaji T, Hanada K. | 10/10/2020 |
| Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD. | Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD.
van den Berge M, Brandsma CA, Faiz A, de Vries M, Rathnayake SNH, Paré PD, Sin DD, Bossé Y, Laviolette M, Nickle DC, Hao K, Obeidat M, Dragani TA, Colombo F, Timens W, Postma DS. | 09/19/2020 |
| optively transferred wide-type B cells partially recovered B-cell activation and autoantibody production in SMS1 deficient bm12-induced lupus mice. Moreover, the SMS1 mRNA level in B cells of SLE patients was increased and positively correlated with the serum anti-dsDNA level, IgG and globulin titers. | Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.
Wang C, Ming B, Wu X, Wu T, Cai S, Hu P, Tang J, Tan Z, Liu C, Zhong J, Zheng F, Dong L., Free PMC Article | 12/21/2019 |
| SMS1 could inhibit EMT and the migration and invasion of MDAMB231 cells via TGFbeta/Smad signaling pathway. | Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.
Liu S, Hou H, Zhang P, Wu Y, He X, Li H, Yan N., Free PMC Article | 06/1/2019 |
| findings suggest that complex formation between SMS1 and GCS is part of a critical mechanism controlling the metabolic fate of Cer in the Golgi. | Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.
Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, Saeki T, Kumasaka T, Koizumi T, Arai S, Wada I, Yokoyama K, Sugiura T, Yamashita A., Free PMC Article | 03/23/2019 |
| An oncogene-Bcr-Abl-has been demonstrated to drive such a mechanism that up-regulates the expression of a functionally important target gene, SMS1. | Bcr-Abl regulation of sphingomyelin synthase 1 reveals a novel oncogenic-driven mechanism of protein up-regulation.
Moorthi S, Burns TA, Yu GQ, Luberto C., Free PMC Article | 02/16/2019 |
| PECULIARITIES OF THE STRUCTURE AND EXPRESSION OF HUMAN SPHINGOMYELIN SYNTHASE 1 GENE (SGMS1). | PECULIARITIES OF THE STRUCTURE AND EXPRESSION OF HUMAN SPHINGOMYELIN SYNTHASE 1 GENE (SGMS1).
Filippenkov IB, Dergunova LV, Rozhkova AV, Sudarkina OY, Limborska SA. | 09/29/2018 |
| The inhibition of SMS 1 activity induced CD cells to lose their epithelial phenotype and to undergo an epithelial-mesenchymal transition (EMT) process. | The inhibition of sphingomyelin synthase 1 activity induces collecting duct cells to lose their epithelial phenotype.
Brandán YR, Guaytima EDV, Favale NO, Pescio LG, Sterin-Speziale NB, Márquez MG. | 04/21/2018 |
| the SGMS1 gene exhibits a complex regulation at the post-transcriptional level | Multi-step splicing of sphingomyelin synthase linear and circular RNAs.
Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. | 04/14/2018 |
| SMS regulates the expression and function of drug transporters P-gp and MRP2. | SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells.
Jin G, Li Y, Zhu Y, Du L, Yan J, Yang Q. | 09/30/2017 |
| HepG2 cells stably transfected with SMS1 (HepG2-SMS1) exhibit elevated enzyme activity in vitro and increased sphingomyelin content (mainly C22:0- and C24:0-sphingomyelin) but lower hexosylceramide (Hex-Cer) levels. | Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1.
Deevska GM, Dotson PP 2nd, Karakashian AA, Isaac G, Wrona M, Kelly SB, Merrill AH Jr, Nikolova-Karakashian MN., Free PMC Article | 06/24/2017 |
| findings suggest that the C-terminal tails of SMSs are involved in homodimer formation, which is required for efficient transport from the ER. | Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum.
Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Tanikawa T, Oka S, Tanaka Y, Arai S, Wada I, Sugiura T, Yamashita A., Free PMC Article | 06/3/2017 |
| Sphingomyelin synthase 1 positively regulates KCNQ1/KCNE1 channel density in a protein kinase D-dependent manner. | Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
Wu M, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song WJ., Free PMC Article | 06/3/2017 |
| A study of the expression of the full-length SMS1 protein and the sum of the alternative transcripts encoding this protein in human tissues. | Comparative analysis of sphingomyelin synthase 1 gene expression at the transcriptional and translational levels in human tissues.
Sudarkina OY, Filippenkov IB, Brodsky IB, Limborska SA, Dergunova LV. | 04/30/2016 |
| The structural organization of 5'-UTR variants of SGMS1 transcripts, directed by alternative promoters, is substantially different; this can provide regulation of the gene functioning on post-transcriptional level. | [Alternative promoters localised in SGMS1 gene introns take part in regulation of its expression in human tissues].
Rozhkova AV, Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. | 07/25/2015 |
| We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women. | Dysregulated sphingolipid metabolism in endometriosis.
Lee YH, Tan CW, Venkatratnam A, Tan CS, Cui L, Loh SF, Griffith L, Tannenbaum SR, Chan JK., Free PMC Article | 01/24/2015 |
| SGMS activity impacts on amyloid precursor protein processing to produce amyloid-beta (Abeta) and it could be a contributing factor in Abeta pathology associated with Alzheimer's disease. | Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation.
Hsiao JH, Fu Y, Hill AF, Halliday GM, Kim WS., Free PMC Article | 01/17/2015 |
| The amount of SMS1 transcripts varies considerably between different human tissues. | The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression.
Dergunova LV, Rozhkova AV, Sudarkina OY, Limborska SA. | 07/5/2014 |
| Findings indicate that Sms1 is a downstream target of Bcr-abl, involved in sustaining cell proliferation of Bcr-abl-positive cells. | Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene.
Burns TA, Subathra M, Signorelli P, Choi Y, Yang X, Wang Y, Villani M, Bhalla K, Zhou D, Luberto C., Free PMC Article | 09/7/2013 |