| MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy. | MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
Pujol C, Lebigot E, Gaignard P, Galai S, Kraoua I, Bault JP, Dard R, Youssef-Turki IB, Omar S, Boutron A, Wai T, Slama A., Free PMC Article | 03/6/2023 |
| Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes. | Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes.
Xu L, Phelix CF, Chen LY., Free PMC Article | 12/18/2021 |
| Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway. | Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway.
Kuerbanjiang M, Gu L, Xu C, Xu WT, Wen S, Xue H, Xu Q., Free PMC Article | 11/13/2021 |
| Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy. | Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy.
Zhu H, Wan H, Wu L, Li Q, Liu S, Duan S, Huang Z, Zhang C, Zhang B, Xing C, Yuan Y., Free PMC Article | 10/16/2021 |
| Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases. | Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.
Lee J, Jin Z, Lee D, Yun JH, Lee W., Free PMC Article | 02/27/2021 |
| The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. | The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
Zangari J, Petrelli F, Maillot B, Martinou JC., Free PMC Article | 02/13/2021 |
| In contrast to MPC1, which co-purifies with a host chaperone, we demonstrated that MPC2 homo-oligomers promote efficient pyruvate transport into proteoliposomes. The derived functional requirements and kinetic features of MPC2 resemble those previously demonstrated for MPC in the literature | Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.
Nagampalli RSK, Quesñay JEN, Adamoski D, Islam Z, Birch J, Sebinelli HG, Girard RMBM, Ascenção CFR, Fala AM, Pauletti BA, Consonni SR, de Oliveira JF, Silva ACT, Franchini KG, Leme AFP, Silber AM, Ciancaglini P, Moraes I, Dias SMG, Ambrosio ALB., Free PMC Article | 09/14/2019 |
| MPC2 rs10489202 was genome-wide significantly associated with schizophrenia. The expression quantitative trait loci analysis in lymphoblastoid cell lines from East Asian donors revealed that MPC2 rs10489202 was specifically and significantly associated with the expression of TIPRL gene. | Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.
Yang Y, Wang L, Li L, Li W, Zhang Y, Chang H, Xiao X, Li M, Lv L., Free PMC Article | 03/9/2019 |
| The data demonstrated that CtBP1 directly bound to the promoters of MPC1 and MPC2 and transcriptionally repressed them, leading to increased levels of free NADH in the cytosol and nucleus, thus positively feeding back CtBP1's functions. | C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells.
Deng Y, Li H, Yin X, Liu H, Liu J, Guo D, Shi Z., Free PMC Article | 01/12/2019 |
| Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. | Hypoxia induces lactate secretion and glycolytic efflux by downregulating mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells.
Wang D, Wang Q, Yan G, Qiao Y, Zhu B, Liu B, Tang C. | 11/3/2018 |
| Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome. | MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer.
Li X, Ji Y, Han G, Li X, Fan Z, Li Y, Zhong Y, Cao J, Zhao J, Zhang M, Wen J, Goscinski MA, Nesland JM, Suo Z., Free PMC Article | 09/30/2017 |
| a significant association between MPC2 variant rs10489202 and Schizophrenia susceptibility in Han Chinese (Meta-Analysis) | Association of NKAPL, TSPAN18, and MPC2 gene variants with schizophrenia based on new data and a meta-analysis in Han Chinese.
Li Z, Shen T, Xin R, Liang B, Jiang J, Ling W, Wei B, Su L. | 06/10/2017 |
| Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation. | A mathematical model predicting host mitochondrial pyruvate transporter activity to be a critical regulator of Mycobacterium tuberculosis pathogenicity.
Mehrotra P, Rao KVS, Chatterjee S. | 06/3/2017 |
| These results reveal a novel post-translational regulation of MPC1 by Sirt3, which is important for its activity and colon cancer cell growth. | Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.
Liang L, Li Q, Huang L, Li D, Li X. | 04/23/2016 |
| Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. | A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.
Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J., Free PMC Article | 02/28/2015 |
| found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. | Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese.
Jin C, Zhang Y, Wang J, Zhou Z, Sha W, Wang M, Zhang F, Li J, Li J, Yu S, Qi S, Yuan J. | 05/17/2014 |
| characterization of the rat ortholog | Structural characterization of a heterogeneous family of rat brain mRNAs.
Tsou AP, Lai C, Danielson P, Noonan DJ, Sutcliffe JG., Free PMC Article | 03/25/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A. | 08/12/2009 |