| Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression. | Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression.
Liu YQ, Xu YW, Zheng ZT, Li D, Hong CQ, Dai HQ, Wang JH, Chu LY, Liao LD, Zou HY, Li EM, Xie JJ, Fang WK. | 04/5/2024 |
| Golgi retention and oncogenic KIT signaling via PLCgamma2-PKD2-PI4KIIIbeta activation in gastrointestinal stromal tumor cells. | Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.
Obata Y, Kurokawa K, Tojima T, Natsume M, Shiina I, Takahashi T, Abe R, Nakano A, Nishida T. | 10/5/2023 |
| Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway. | Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway.
Feng R, Wang X, Chen H, Cao C, Liu T, Zhao T, Chen H, Tian R, Ni Y, Tian X, Hu Z, Ma J, Gong D. | 02/13/2023 |
| Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. | Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G., Free PMC Article | 10/30/2021 |
| High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition. | High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition.
Pang Z, Wang Y, Ding N, Chen X, Yang Y, Wang G, Liu Q, Du J., Free PMC Article | 08/29/2020 |
| PKD2 and PKD3 were the two major isoforms of PKD overexpressed in breast cancer. Suppressing either PKD2 or PKD3 was able to reduce breast cancer cell proliferation and metastasis. | Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.
Liu Y, Li J, Ma Z, Zhang J, Wang Y, Yu Z, Lin X, Xu Z, Su Q, An L, Zhou Y, Ma X, Yang Y, Wang F, Chen Q, Zhang Y, Wang J, Zheng H, Shi A, Yu S, Zhang J, Zhao W, Chen L., Free PMC Article | 03/28/2020 |
| Our findings demonstrate that recurrent and high-grade salivary gland polymorphous adenocarcinomas are underpinned by PRKD1 E710D hotspot mutations or PRKD2 rearrangements | Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.
Sebastiao APM, Pareja F, Kumar R, Brown DN, Silveira C, da Silva EM, Lee JY, Del A, Katabi N, Chiosea S, Weigelt B, Reis-Filho JS, Seethala RR., Free PMC Article | 01/25/2020 |
| Study identified, for the first time, a functional crosstalk between protein kinase D2 (PKD2) and Aurora A kinase in cancer cells. The data demonstrate that PKD2 is catalytically active during the G2-M phases of the cell cycle, and inactivation or depletion of PKD2 causes delay in mitotic entry due to downregulation of Aurora A, an effect that can be rescued by overexpression of Aurora A. | Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes.
Roy A, Veroli MV, Prasad S, Wang QJ., Free PMC Article | 09/28/2019 |
| exogenous SCF, CCL5 and CCL11 reversed the effect on MCs migration inhibited by PKD2/3 silencing. Mechanistically, PKD2/3 interacted with Erk1/2 and activated Erk1/2 or NF-kappaB signaling pathway, leading to AP-1 or NF-kappaB binding to the promoter of scf, ccl5 and ccl11. | Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.
Xu W, Qian J, Zeng F, Li S, Guo W, Chen L, Li G, Zhang Z, Wang QJ, Deng F., Free PMC Article | 06/22/2019 |
| This review discusses the versatile functions of PKD2 from the perspective of cancer hallmarks as described by Hanahan and Weinberg. The PKD2 status, signaling pathways affected in different tumor types and the molecular mechanisms that lead to tumorigenesis and tumor progression are presented. [review] | Protein kinase D2: a versatile player in cancer biology.
Azoitei N, Cobbaut M, Becher A, Van Lint J, Seufferlein T. | 03/16/2019 |
| None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 genes. | Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.
Piscuoglio S, Fusco N, Ng CK, Martelotto LG, da Cruz Paula A, Katabi N, Rubin BP, Skálová A, Weinreb I, Weigelt B, Reis-Filho JS., Free PMC Article | 11/4/2017 |
| This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1, PKD2, and PKD3 monomers. | A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.
Aicart-Ramos C, He SD, Land M, Rubin CS., Free PMC Article | 06/3/2017 |
| Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 to be positive regulators of proliferation. | Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
Durand N, Borges S, Storz P., Free PMC Article | 04/2/2016 |
| the knockdown of PKD2 reduces cell death and promotes polyploidization induced by PMA. PMA/PKD2-mediated necrosis via PARP cleavage involves both SOD1-dependent and -independent pathways. | Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
Chen YL, Kan WM. | 12/5/2015 |
| The results implied that PKD2 silencing might inhibit migration of MCF7/DOX cells without affecting chemoresistance significantly | Protein kinase D2 silencing reduced motility of doxorubicin-resistant MCF7 cells.
Alpsoy A, Gündüz U. | 10/24/2015 |
| PRKD2 silencing induces glioma cell senescence via p53-dependent and -independent pathways. | Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.
Bernhart E, Damm S, Heffeter P, Wintersperger A, Asslaber M, Frank S, Hammer A, Strohmaier H, DeVaney T, Mrfka M, Eder H, Windpassinger C, Ireson CR, Mischel PS, Berger W, Sattler W., Free PMC Article | 10/3/2015 |
| Loss of PKD2 enhanced KC proliferative potential while loss of PKD3 resulted in a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability. | Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.
Ryvkin V, Rashel M, Gaddapara T, Ghazizadeh S., Free PMC Article | 07/4/2015 |
| Activation of PKD2 and further increase of PKD3 activity leads to additional phosphorylation and inhibition of endogenous phosphatase slingshot 1L. | Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.
Döppler H, Bastea LI, Borges S, Spratley SJ, Pearce SE, Storz P., Free PMC Article | 01/10/2015 |
| Both PKD2 and GOLPH3 play important roles in the progression of human gliomas by promoting cell proliferation. | Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
Zhou X, Xue P, Yang M, Shi H, Lu D, Wang Z, Shi Q, Hu J, Xie S, Zhan W, Yu R. | 12/20/2014 |
| PKD2 controls secretion of MMP7 and 9 in an isoform-specific manner | Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.
Wille C, Köhler C, Armacki M, Jamali A, Gössele U, Pfizenmaier K, Seufferlein T, Eiseler T., Free PMC Article | 10/18/2014 |
| PRKD2 mediates BAZF gene expression by VEGF-A stimulation. | Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.
Miwa D, Sakaue T, Inoue H, Takemori N, Kurokawa M, Fukuda S, Omi K, Goishi K, Higashiyama S. | 11/16/2013 |
| PRKD2 is a potential target to interfere with glioblastoma cell migration and invasion, two major determinants contributing to recurrence of glioblastoma after multimodality treatment. | Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.
Bernhart E, Damm S, Wintersperger A, DeVaney T, Zimmer A, Raynham T, Ireson C, Sattler W., Free PMC Article | 09/21/2013 |
| results suggest that PKD2 is involved in the regulation of PP2A activity in activated T cells through phosphorylation of Ser171 of SET | Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A.
Irie A, Harada K, Araki N, Nishimura Y., Free PMC Article | 06/15/2013 |
| We have identified PKD2 and PKD3, especially PKD3, as novel cell growth regulators in HCC1806 triple-negative breast cancer cells | Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.
Hao Q, McKenzie R, Gan H, Tang H. | 04/13/2013 |
| found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit | Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.
Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H., Free PMC Article | 09/1/2012 |