| Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects. | Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects.
Oxman E, Li H, Wang HY, Zohn IE., Free PMC Article | 05/3/2024 |
| Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression. | Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.
Zhang J, Xin Y, Ling X, Liang H, Zhang L, Fang C, Ma J. | 01/9/2024 |
| The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis. | The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.
Vaughan N, Scholz N, Lindon C, Licchesi JDF., Free PMC Article | 08/6/2022 |
| Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis. | Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.
Li C, Liu Y, Lv Z, Zheng H, Li Z, Zhang J, Bao H, Zhang S, Xiong J, Jin H, Yu L, Ai S, Wang Y, Xiao X, Su T, Liang P. | 10/23/2021 |
| The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1. | The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
Harris LD, Le Pen J, Scholz N, Mieszczanek J, Vaughan N, Davis S, Berridge G, Kessler BM, Bienz M, Licchesi JDF., Free PMC Article | 08/28/2021 |
| CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism. | CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism.
Jiang QL, Feng SJ, Yang ZY, Xu Q, Wang SZ., Free PMC Article | 07/3/2021 |
| HECTD1 regulates the expression of SNAIL: Implications for epithelialmesenchymal transition. | HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition.
Wang X, De Geyter C, Jia Z, Peng Y, Zhang H., Free PMC Article | 02/13/2021 |
| we have now identified HECTD1 as an important factor in promoting Base excision repair (BER) in chromatin. | HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.
Bennett L, Madders ECET, Parsons JL., Free PMC Article | 03/21/2020 |
| SiO2 concomitantly increased circHECTD1 expression, which, in turn, inhibited HECTD1 protein expression. | circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.
Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W, Chao J., Free PMC Article | 11/16/2019 |
| HECTD1 may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I. | The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.
Aleidi SM, Yang A, Sharpe LJ, Rao G, Cochran BJ, Rye KA, Kockx M, Brown AJ, Gelissen IC. | 06/2/2018 |
| Hectd1 regulates the protein level of IQGAP1 through ubiquitination. | HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.
Shen X, Jia Z, D'Alonzo D, Wang X, Bruder E, Emch FH, De Geyter C, Zhang H., Free PMC Article | 06/24/2017 |
| our high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted in a novel arrangement; we call this fold the Basic Tilted Helix Bundle (BTHB) domain. | Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.
Helander S, Montecchio M, Lemak A, Farès C, Almlöf J, Yi Y, Yee A, Arrowsmith C, DhePaganon S, Sunnerhagen M., Free PMC Article | 06/28/2014 |
| HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling. | HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P., Free PMC Article | 04/20/2013 |