| Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function. | Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
Idris M, Mitchell DJ, Gordon R, Sidharthan NP, Butcher NJ, Minchin RF. | 07/24/2021 |
| Study in SULT4A1 knockout mice demonstrates that depletion of SULT4A1 induces oxidative stress in neurons and expression of SULT4A1 in human SH-SY5Y cells protects against oxidative-stress-induced mitochondrial dysfunction and cell death. Results suggest that SULT4A1 may have a crucial protective function against mitochondrial dysfunction and oxidative stress. | SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Hossain MI, Marcus JM, Lee JH, Garcia PL, Gagné JP, Poirier GG, Falany CN, Andrabi SA., Free PMC Article | 05/30/2020 |
| Study using SH-SY5Y cells, human induced pluripotent stem cells, and mouse embryonic tissue revealed time-dependent changes in SULT4A1 protein and MBNL/CELF protein during differentiation supported their role in correctly splicing the SULT4A1 mRNA. Furthermore, ectopic expression of each factor produced efficient splicing in the minigene assay as well as correct splicing of the endogenous SULT4A1 mRNA. | The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation.
Idris M, Butcher NJ, Minchin RF. | 08/31/2019 |
| These results show that SULT4A1 is widely expressed in human tissues, but mostly as a splice variant that produces a rapidly degraded protein. Dimerization protects the protein from degradation. | Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination.
Sidharthan NP, Butcher NJ, Mitchell DJ, Minchin RF., Free PMC Article | 10/24/2015 |
| Across three psychiatric disorders (n=2815 patients), we observed no consistent association between SULT4A1-1 status and atypical antipsychotic effect | SULT4A1 haplotype: conflicting results on its role as a biomarker of antipsychotic response.
Wang D, Li Q, Favis R, Jadwin A, Chung H, Fu DJ, Savitz A, Gopal S, Cohen N. | 07/4/2015 |
| This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects. | Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group.
Ramsey TL, Liu Q, Brennan MD., Free PMC Article | 02/14/2015 |
| determination of SULT4A1-1 haplotype status might be useful for identifying patients who show an enhanced response to long-term olanzapine treatment. | Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response.
Ramsey TL, Meltzer HY, Brock GN, Mehrotra B, Jayathilake K, Bobo WV, Brennan MD., Free PMC Article | 07/23/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X., Free PMC Article | 12/5/2010 |
| Cytosolic SULT4A1 interacts with PIN1. | Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Mitchell DJ, Minchin RF. | 01/21/2010 |
| These results provide the first evidence of how genetic variation in Sult4A1 may be related to clinical symptoms and cognitive function in schizophrenia | Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder.
Meltzer HY, Brennan MD, Woodward ND, Jayathilake K, Meltzer HY, Brennan MD, Woodward ND, Jayathilake K. | 01/21/2010 |
| The lack of polymorphisms in the coding region of the SULT4A1 gene is highly unusual and, along with its high conservation between species, suggests that SULT4A1 may have an important function in vivo. | Lack of exonic sulfotransferase 4A1 mutations in controls and schizophrenia cases.
Lewis AG, Minchin RF, Lewis AG, Minchin RF. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. Lack of exonic sulfotransferase 4A1 mutations in controls and schizophrenia cases.
Lewis AG, Minchin RF, Lewis AG, Minchin RF. Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder.
Meltzer HY, Brennan MD, Woodward ND, Jayathilake K, Meltzer HY, Brennan MD, Woodward ND, Jayathilake K. | 10/8/2008 |
| Candidate gene for schizophrenia susceptibility. | Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia.
Brennan MD, Condra J. | 01/21/2010 |
| the first immunohistochemical localization of SULT4A1 in human brain | Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study.
Liyou NE, Buller KM, Tresillian MJ, Elvin CM, Scott HL, Dodd PR, Tannenberg AE, McManus ME. | 01/21/2010 |