| Regulation of SPDEF expression by DNA methylation in advanced prostate cancer. | Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.
Vatanmakanian M, Steffan JJ, Koul S, Ochoa AC, Chaturvedi LS, Koul HK., Free PMC Article | 11/1/2023 |
| Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. | Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
Hou Y, Zheng S, Zou F, Wang D, Da H, Zhou Y, Fan X, Liu J, Zhao H, He J, Li H, Sun X, Liu Y. | 08/30/2023 |
| SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer. | SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.
Li J, Wan X, Xie D, Yuan H, Pei Q, Luo Y, Chen Y, Xian J, Ye T., Free PMC Article | 08/30/2023 |
| The role of SPDEF in cancer: promoter or suppressor. | The role of SPDEF in cancer: promoter or suppressor.
Bao KC, Wang FF. | 01/11/2023 |
| The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance. | The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance.
Ye T, Li J, Feng J, Guo J, Wan X, Xie D, Liu J., Free PMC Article | 02/5/2022 |
| SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1. | SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1.
Wang Y, Ren X, Li W, Cao R, Liu S, Jiang L, Cheng B, Xia J., Free PMC Article | 12/25/2021 |
| Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjogren's syndrome-associated dry eyes. | Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes.
Shoji J, Inada N, Tomioka A, Yamagami S., Free PMC Article | 01/9/2021 |
| Targeting SPDEF led to proportional decreases in MUC5AC expression in human bronchial epithelial cells stimulated with IL-13. Near-complete targeting of SPDEF abolished IL-13-induced MUC5AC expression and goblet cell differentiation. Targeting of SPDEF prevented IL-13-induced impairment of mucociliary clearance. | Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.
Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ., Free PMC Article | 08/1/2020 |
| Hypermethylation of SPDEF gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which was associated with the frequency of alcohol and tobacco use. | Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse.
Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G, IMAGEN Consortium. | 11/23/2019 |
| SPDEF is overexpressed in gastric cancer and triggers cell proliferation by forming a positive regulation loop with FoxM1 | SPDEF is overexpressed in gastric cancer and triggers cell proliferation by forming a positive regulation loop with FoxM1.
Wu J, Qin W, Wang Y, Sadik A, Liu J, Wang Y, Song P, Wang X, Sun K, Zeng J, Wang L. | 10/12/2019 |
| This study reports the novel findings that PDEF suppresses Twist1 partly via CK18 and that PDEF/Twist1 could help distinguish between lethal and indolent prostate cancer. | Prostate-Derived Ets Factor (PDEF) Inhibits Metastasis by Inducing Epithelial/Luminal Phenotype in Prostate Cancer Cells.
Wang F, Koul S, Shanmugam PST, Dong Q, Koul HK. | 08/31/2019 |
| PDEF-knockout inhibits gastric cancer cell proliferation, migration and invasion. | CRISPR/Cas9-mediated knockout of the PDEF gene inhibits migration and invasion of human gastric cancer AGS cells.
Zhang YQ, Pei JH, Shi SS, Guo XS, Cui GY, Li YF, Zhang HP, Hu WQ. | 06/15/2019 |
| PDEF is associated with markers of bad prognosis, supporting its role as a growth promoter in ER(-) breast cancer | Clinical significance of PDEF factor expression and its relation to androgen receptor in ER(-) breast cancer.
Cao L, Li C, Xu C, Xiang G, Liu F, Liu X, Jiao J, Lv S, Niu Y. | 02/23/2019 |
| This is, to our knowledge, the first report of decreased expression of TFF3, SPDEF, KLF4, and goblet cell population in the colon of patients with HSCR. Altered goblet cell function may result in intestinal barrier dysfunction contributing to the development of HAEC. | Altered goblet cell function in Hirschsprung's disease.
Nakamura H, Tomuschat C, Coyle D, O'Donnel AM, Lim T, Puri P. | 07/21/2018 |
| Loss of SPDEF promotes prostate cancer growth and metastasis and can be caused by dysregulation or therapeutic inhibition of androgen receptor signaling. | Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.
Chen WY, Tsai YC, Yeh HL, Suau F, Jiang KC, Shao AN, Huang J, Liu YN. | 05/26/2018 |
| Results demonstrated that SPDEF expression is increased during IL-13-induced goblet cell differentiation, which correlates to hypermethylation of CpG number 8 in the SPDEF promoter. These findings suggest that aberrant DNA methylation of SPDEF is one of the factors underlying mucus hypersecretion in COPD. | Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.
Song J, Heijink IH, Kistemaker LEM, Reinders-Luinge M, Kooistra W, Noordhoek JA, Gosens R, Brandsma CA, Timens W, Hiemstra PS, Rots MG, Hylkema MN., Free PMC Article | 01/27/2018 |
| Taken together, these results suggested a novel function for SPDEF wherein it represses canonical Wnt/b-catenin transcriptional activity through selectively displacing b-catenin from chromatin targets. | SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.
Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF., Free PMC Article | 09/9/2017 |
| these findings demonstrate PDEF to be an oncogenic driver of breast cancer and a biomarker of poor prognosis in this cancer. Based on this understanding and the limited expression of PDEF in normal human tissues, the development of PDEF-based therapeutics for prevention and treatment of breast cancer is also discussed | Prostate-derived Ets factor, an oncogenic driver in breast cancer.
Sood AK, Geradts J, Young J. | 06/24/2017 |
| These results indicate efficient SPDEF silencing and downregulation of mucus-related gene expression by epigenetic editing, in human lung epithelial cells. | Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells.
Song J, Cano-Rodriquez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN. | 06/24/2017 |
| miR-125b inhibits SPDEF expression modulating goblet cell differentiation and mucus secretion in asthma | miR-125b inhibits goblet cell differentiation in allergic airway inflammation by targeting SPDEF.
Liu Z, Chen X, Wu Q, Song J, Wang L, Li G. | 03/4/2017 |
| PDEF regulates many genes, which participate in various stages of tumor development. | Signatures of prostate-derived Ets factor (PDEF) in cancer.
Mahajan N. | 02/18/2017 |
| PDEF gene expression is associated with the extent of bladder neoplasia and PDEF modulated the expressions of EMT-related genes. | Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells.
Tsui KH, Lin YH, Chung LC, Chuang ST, Feng TH, Chiang KC, Chang PL, Yeh CJ, Juang HH. | 08/13/2016 |
| SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.
Cheng XH, Black M, Ustiyan V, Le T, Fulford L, Sridharan A, Medvedovic M, Kalinichenko VV, Whitsett JA, Kalin TV., Free PMC Article | 07/25/2015 |
| We found significantly increased SPDEF and MUC5AC expression in CRSwNP patients compared to the controls (P < .05); the mRNA level of SPDEF was positively correlated with MUC5AC expression in CRS patients (P < .05). | Enhanced expression of SAM-pointed domain-containing Ets-like factor in chronic rhinosinusitis with nasal polyps.
Bai J, Miao B, Wu X, Luo X, Ma R, Zhang J, Li L, Shi J, Li H. | 04/18/2015 |
| we identified four proteins with different expression in paclitaxel resistant cells, i.e., serpin B3, serpin B4, heat shock protein 27 (all three upregulated) and cytokeratin 18 (downregulated). | HOXB13 regulates the prostate-derived Ets factor: implications for prostate cancer cell invasion.
Kim IJ, Kang TW, Jeong T, Kim YR, Jung C. | 01/31/2015 |