| Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis. | Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis.
Chen YR, Wu YS, Wang WS, Zhang JS, Wu QG. | 03/20/2021 |
| High CIZ1 expression is associated with Hemangioma of the Tongue. | CIZ1 Expression Is Upregulated in Hemangioma of the Tongue.
Wang Y, Li X, Zhang J, Liu Q, Gao P, Li D, Zhang S, Liu J. | 04/4/2020 |
| silencing of CIZ1 suppressed bladder cancer cell proliferation through inducing apoptosis and reducing cell cycle progression | CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis.
Chen X, Wang P, Wang S, Li J, Ou T, Zeng X. | 10/5/2019 |
| data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory. | Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1).
Sunwoo H, Colognori D, Froberg JE, Jeon Y, Lee JT., Free PMC Article | 06/9/2018 |
| our study demonstrated that CIZ1 is a positive regulator of YAP signaling, and CIZ1 might be a therapeutic target for hepatocellular carcinoma | CIZ1 interacts with YAP and activates its transcriptional activity in hepatocellular carcinoma cells.
Lei L, Wu J, Gu D, Liu H, Wang S. | 02/18/2017 |
| CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells. | CIZ1 is upregulated in hepatocellular carcinoma and promotes the growth and migration of the cancer cells.
Wu J, Lei L, Gu D, Liu H, Wang S. | 02/4/2017 |
| CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. | Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.
Copeland NA, Sercombe HE, Wilson RH, Coverley D. | 01/16/2016 |
| The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany. | Mutations in CIZ1 are not a major cause for dystonia in Germany.
Dufke C, Hauser AK, Sturm M, Fluhr S, Wächter T, Leube B, Auburger G, Ott T, Bauer P, Gasser T, Grundmann K. | 01/2/2016 |
| Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC | CIZ1 promoted the growth and migration of gallbladder cancer cells.
Zhang D, Wang Y, Dai Y, Wang J, Suo T, Pan H, Liu H, Shen S, Liu H. | 07/25/2015 |
| This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families. | No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families.
Ma L, Chen R, Wang L, Yang Y, Wan X. | 06/28/2014 |
| CIZ1 may be involved in colon cancer progression by regulating cell proliferation, cell cycle, apoptosis and colony formation. | CIZ1 regulates the proliferation, cycle distribution and colony formation of RKO human colorectal cancer cells.
Yin J, Wang C, Tang X, Sun H, Shao Q, Yang X, Qu X. | 05/31/2014 |
| Variant Ciz1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer. | Variant Ciz1 is a circulating biomarker for early-stage lung cancer.
Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D., Free PMC Article | 01/26/2013 |
| Mutations in CIZ1 may cause adult onset, primary cervical dystonia | Mutations in CIZ1 cause adult onset primary cervical dystonia.
Xiao J, Uitti RJ, Zhao Y, Vemula SR, Perlmutter JS, Wszolek ZK, Maraganore DM, Auburger G, Leube B, Lehnhoff K, LeDoux MS., Free PMC Article | 06/9/2012 |
| alternatively spliced variant of Ciz1 is associated with cancer. | Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray.
Rahman FA, Aziz N, Coverley D., Free PMC Article | 02/5/2011 |
| An isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in Alzheimer's brains relative to the full-length CIZ1 protein. | Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease.
Dahmcke CM, Büchmann-Møller S, Jensen NA, Mitchelmore C. | 01/21/2010 |
| Ciz1 is a nuclear zinc finger protein interacting with p21, and is a DNA replication factor. The region of Ciz1 necessary for the interaction with ERH spans residues 531-644, encompassing its first zinc finger motif | Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog.
Lukasik A, Uniewicz KA, Kulis M, Kozlowski P. | 01/21/2010 |
| conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication | Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1.
Rahman F, Ainscough JF, Copeland N, Coverley D. | 01/21/2010 |
| Findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. | Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.
den Hollander P, Rayala SK, Coverley D, Kumar R. | 01/21/2010 |
| data indicate that Ciz1 is localized in the nucleus and is expressed in a wide range of tissues, especially the pancreas and the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 | Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC.
Warder DE, Keherly MJ. | 01/21/2010 |