| Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome. | Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome.
Epting D, Senaratne LDS, Ott E, Holmgren A, Sumathipala D, Larsen SM, Wallmeier J, Bracht D, Frikstad KM, Crowley S, Sikiric A, Barøy T, Käsmann-Kellner B, Decker E, Decker C, Bachmann N, Patzke S, Phelps IG, Katsanis N, Giles R, Schmidts M, Zucknick M, Lienkamp SS, Omran H, Davis EE, Doherty D, Strømme P, Frengen E, Bergmann C, Misceo D., Free PMC Article | 11/27/2021 |
| A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear beta-catenin levels. | A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
Wen S, Qin Y, Wang R, Yang L, Zeng H, Zhu P, Li Q, Qiu Y, Chen S, Liu Y, Hou Y, Tang X, Liu M, Tu G., Free PMC Article | 10/16/2021 |
| Chibby expression was decreased in gastric cancer samples and altered beta-catenin localization in cultured gastric cancer cells. | Chibby is a weak regulator of β-catenin activity in gastric epithelium.
Li FQ, Chiriboga L, Black MA, Takemaru KI, Raffaniello RD. | 12/14/2019 |
| Our study reveals an association between Chibby expression and cancer aerobic glycolysis, which highlights the importance of Wnt/beta-catenin pathway in regulation of energy metabolism of NPC. These results indicate that Chibby and PDK1 are the potential target for NPC treatment. | Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade.
Cai CF, Ye GD, Shen DY, Zhang W, Chen ML, Chen XX, Han DX, Mi YJ, Luo QC, Cai WY, Yang SY., Free PMC Article | 05/11/2019 |
| FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. | BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.
Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI., Free PMC Article | 06/24/2017 |
| chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. | Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes.
Fischer V, Wong M, Li FQ, Takemaru KI., Free PMC Article | 06/24/2017 |
| Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. | Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition.
Killoran RC, Sowole MA, Halim MA, Konermann L, Choy WY., Free PMC Article | 04/22/2017 |
| CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. | 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
Mancini M, Leo E, Takemaru K, Campi V, Castagnetti F, Soverini S, De Benedittis C, Rosti G, Cavo M, Santucci MA, Martinelli G., Free PMC Article | 04/16/2016 |
| Results show the hypermethylation of CBY1 and BCL2-like11 promoters proceeding from DNMT1 is a crucial component of their reduced expression, but it is not directly involved in chronic myeloid leukemia resistance to imatinib. | DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia.
Leo E, Mancini M, Castagnetti F, Gugliotta G, Santucci MA, Martinelli G. | 03/26/2016 |
| Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. | Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells.
Xu J, Ren G, Zhao DA, Li BA, Cai CF, Zhou Y, Luo XY. | 10/31/2015 |
| the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation | BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia.
Leo E, Mancini M, Aluigi M, Luatti S, Castagnetti F, Testoni N, Soverini S, Santucci MA, Martinelli G., Free PMC Article | 03/7/2015 |
| Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. | Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells.
Mancini M, Leo E, Takemaru K, Campi V, Borsi E, Castagnetti F, Gugliotta G, Santucci MA, Martinelli G. | 02/1/2014 |
| Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. | No important role for genetic variation in the Chibby gene in monogenic and complex obesity.
Van Camp JK, Zegers D, Verhulst SL, Van Hoorenbeeck K, Massa G, Verrijken A, Desager KN, Van Gaal LF, Van Hul W, Beckers S. | 02/1/2014 |
| C-terminal polycystin-2 influences the interaction with PIGEA14 | Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: a QCM study based on solid supported membranes.
Morick D, Schatz M, Hubrich R, Hoffmeister H, Krefft A, Witzgall R, Steinem C. | 10/26/2013 |
| Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. | A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation.
Steere N, Chae V, Burke M, Li FQ, Takemaru K, Kuriyama R., Free PMC Article | 04/20/2013 |
| The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. | Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.
Mokhtarzada S, Yu C, Brickenden A, Choy WY., Free PMC Article | 04/16/2011 |
| Chibby and clusterin were co-immunoprecipitated with NBPF1. | Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.
Vandepoele K, Staes K, Andries V, van Roy F. | 05/10/2010 |
| These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. | Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.
Li FQ, Mofunanya A, Fischer V, Hall J, Takemaru K., Free PMC Article | 03/29/2010 |
| Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. | Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif.
Mofunanya A, Li FQ, Hsieh JC, Takemaru K., Free PMC Article | 01/21/2010 |
| genes including CHIBBY involved in pediatric ependymomas. | Real-time quantitative PCR analysis of pediatric ependymomas identifies novel candidate genes including TPR at 1q25 and CHIBBY at 22q12-q13.
Karakoula K, Suarez-Merino B, Ward S, Phipps KP, Harkness W, Hayward R, Thompson D, Jacques TS, Harding B, Beck J, Thomas DG, Warr TJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesMaternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R. | 12/3/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R., Free PMC Article | 10/8/2008 |
| 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. | Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.
Li FQ, Mofunanya A, Harris K, Takemaru K., Free PMC Article | 01/21/2010 |
| intrinsically disordered TC-1 interacts with Cby via its transient helical structure | The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity.
Gall C, Xu H, Brickenden A, Ai X, Choy WY., Free PMC Article | 01/21/2010 |
| CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. | Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling.
Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K., Free PMC Article | 01/21/2010 |