| GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel. | GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel.
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T., Free PMC Article | 09/23/2024 |
| Heterogeneity of circulating CXCR5-PD-1[hi]Tph cells in patients of type 2 and type 1 diabetes in Chinese population. | Heterogeneity of circulating CXCR5-PD-1(hi)Tph cells in patients of type 2 and type 1 diabetes in Chinese population.
Su Z, Ma C, Zhao R, Jiang Y, Cai Y, Yong G, Yang T, Xu X. | 05/10/2023 |
| The plasma level of glutamic acid decarboxylase 65 (GAD65) increased in severely autistic Iranian children. | The plasma level of glutamic acid decarboxylase 65 (GAD65) increased in severely autistic Iranian children.
Vazifekhah S, Barfi S, Soleimany F, Aliakbar A, Zavvari F, Karimzadeh F. | 04/23/2022 |
| Similarities between bacterial GAD and human GAD65: Implications in gut mediated autoimmune type 1 diabetes. | Similarities between bacterial GAD and human GAD65: Implications in gut mediated autoimmune type 1 diabetes.
Bedi S, Richardson TM, Jia B, Saab H, Brinkman FSL, Westley M., Free PMC Article | 03/12/2022 |
| Neurological Syndromes Associated with Anti-GAD Antibodies. | Neurological Syndromes Associated with Anti-GAD Antibodies.
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A., Free PMC Article | 02/20/2021 |
| GAD1 but not GAD2 polymorphisms are associated with heroin addiction phenotypes. | GAD1 but not GAD2 polymorphisms are associated with heroin addiction phenotypes.
Shi Y, Li Y, Zhang J, Xiao Y, Yan P, Zhu Y. | 11/28/2020 |
| This binding characteristic is probably attributable to reduced presentation of two conformational epitopes by the N-terminal truncated molecule. These findings support the notion of disease-specific GAD65Ab epitope specificities and emphasize the need to evaluate the applicability of novel assays for different medical conditions. | Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus.
Hampe CS, Radtke JR, Wester A, Carlsson A, Cedervall E, Jönsson B, Ivarsson SA, Elding Larsson H, Larsson K, Lindberg B, Neiderud J, Rolandsson O, Lernmark Å., Free PMC Article | 08/1/2020 |
| Posttransplant blood GAD65 and miR-375 performed equally well in quantifying early graft destruction and predicting graft outcome after islet transplantation in patients with type 1 diabetes. | Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.
Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA., Free PMC Article | 12/14/2019 |
| GAD65 antibody positivity was associated with an increased risk of future Type 2 Diabetes Mellitus in adults--{REVIEW} | The association between GAD65 antibody levels and incident Type 2 Diabetes Mellitus in an adult population: A meta-analysis.
Koopman ADM, Beulens JW, Voerman E, Rauh SP, van der Heijden AA, McDonald TJ, Langendoen-Gort M, Rutters F. | 11/30/2019 |
| we show an interaction of the genetic variation rs2236418 in the GAD2 gene and sex on GABA/glutamate balance in the pregenual anterior cingulate cortex | GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC.
Colic L, Li M, Demenescu LR, Li S, Müller I, Richter A, Behnisch G, Seidenbecher CI, Speck O, Schott BH, Stork O, Walter M., Free PMC Article | 10/26/2019 |
| In individuals with adult-onset diabetes, presence of N-terminally truncated GAD65 autoantibodies is associated with the clinical phenotype of autoimmune type 1 diabetes and predicts insulin therapy. | Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.
Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK, Bonifacio E, Ziegler AG, Leslie RD, Action LADA consortium., Free PMC Article | 12/1/2018 |
| This study showed a significant 58% increase of SCN GAD65/67-ir and a significant 169% increase of SCN GAD67-mRNA in the depression group. | Increased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression.
Wu X, Balesar R, Lu J, Farajnia S, Zhu Q, Huang M, Bao AM, Swaab DF., Free PMC Article | 06/30/2018 |
| healthy donor NK cells showed similar degranulation against both GAD65 AA 114-122 pulsed and unpulsed APCs. The pathogenetic significance of the CD3-CD8dullCD56+ 'memory-like NK cell subset' with increased response upon secondary challenge in diabetics remains to be elucidated | Identification of GAD65 AA 114-122 reactive 'memory-like' NK cells in newly diagnosed Type 1 diabetic patients by HLA-class I pentamers.
Perri V, Gianchecchi E, Cifaldi L, Pellegrino M, Giorda E, Andreani M, Cappa M, Fierabracci A., Free PMC Article | 01/6/2018 |
| Genetic variability in GAD2 and GAD1 contributes to risk of methamphetamine dependence in the Thai population. | Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence.
Veerasakul S, Watiktinkorn P, Thanoi S, Reynolds GP, Nudmamud-Thanoi S. | 08/5/2017 |
| Study propose that aberrant accumulation of immunogenic GAD65 in Golgi membranes facilitates inappropriate presentation to the immune system after release from stressed and/or damaged beta-cells, triggering autoimmunity. | Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity.
Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S., Free PMC Article | 06/10/2017 |
| UV exposed hydrogen peroxide produces hydroxyl radical that may cause protein damage (GAD-65) to the extent of generating neo-epitopes on the molecule, making it immunogenic. | Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.
Moinuddin, Ansari NA, Shahab U, Habeeb S, Ahmad S. | 08/13/2016 |
| we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de-carboxylase 2 (GAD2) 5'-untranslated region | Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus.
Li Q, Qiao ZR, Liu DB, Zeng JT, Zhang J, Bo Y, Zu HY, Hu Q, Wu X, Dong SS. | 04/23/2016 |
| GAD autoantibodies were associated with risk of developing type 1 diabetes. | Autoantibody-defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg Type 1 Diabetes Risk Study after 18 years.
Till AM, Kenk H, Rjasanowski I, Wassmuth R, Walschus U, Kerner W, Schlosser M. | 04/16/2016 |
| Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation. | Tyrosine-phosphatase and glutamate-decarboxylase antibodies after simultaneous pancreas kidney transplantation: do they have an impact on pancreas graft survival?
Rodelo-Haad C, Aguera ML, Martinez-Vaquera S, Pendon-Ruiz de Mier MV, Salmeron-Rodriguez MD, Esquivias E, Navarro MD, Rodriguez-Benot A, Aljama P. | 10/31/2015 |
| Plasma GAD65 qualifies as a marker for early beta-cell loss after intraportal transplantation. | Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.
Ling Z, De Pauw P, Jacobs-Tulleneers-Thevissen D, Mao R, Gillard P, Hampe CS, Martens GA, In't Veld P, Lernmark Å, Keymeulen B, Gorus F, Pipeleers D., Free PMC Article | 09/5/2015 |
| Cohort study shows that mean GAD65 mRNA levels in the prefrontal cortex area 9 are not altered in subjects with schizophrenia but are lower in subjects with schizoaffective disorder | Lower glutamic acid decarboxylase 65-kDa isoform messenger RNA and protein levels in the prefrontal cortex in schizoaffective disorder but not schizophrenia.
Glausier JR, Kimoto S, Fish KN, Lewis DA., Free PMC Article | 08/15/2015 |
| Data suggest that women with gestational diabetes who develop autoantibodies against GAD2 (glutamate decarboxylase 2) exhibit higher blood glucose levels, insulin resistance, and impaired insulin secretion from beta cells in the postpartum period. | Glutamic acid decarboxylase autoantibody-positivity post-partum is associated with impaired β-cell function in women with gestational diabetes mellitus.
Lundberg TP, Højlund K, Snogdal LS, Jensen DM. | 07/25/2015 |
| Phosphate-activated glutaminase and GAD65/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls | Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase.
Burbaeva GSh, Boksha IS, Tereshkina EB, Savushkina OK, Prokhorova TA, Vorobyeva EA. | 05/23/2015 |
| GAD2 SNPs significantly associate with early-onset obsessive compulsive disorder. | Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study.
Mas S, Pagerols M, Gassó P, Ortiz A, Rodriguez N, Morer A, Plana MT, Lafuente A, Lazaro L. | 01/3/2015 |
| The decreased amount of GAD65 and GAD67 suggests the decreased synthesis of neurotransmitter and basic GABA pools that indicates insufficient functioning of the GABA system in the cerebellar cortex of Alzheimer's disease patients. | [A role of glutamate decarboxylase in Alzheimer's disease].
Burbaeva GSh, Boksha IS, Tereshkina EB, Starodubtseva LI, Savushkina OK, Vorob'eva EA, Prokhorova TA. | 12/20/2014 |