| The Association between Obesity Susceptibility and Polymorphisms of MC4R, SH2B1, and NEGR1 in Tibetans. | The Association between Obesity Susceptibility and Polymorphisms of MC4R, SH2B1, and NEGR1 in Tibetans.
Huang T, Zhang X, Li Q, Li X, Yao J, Song J, Chen Y, Ye L, Li C, Xiran P, Wen Y. | 08/15/2024 |
| Plasma Neuronal Growth Regulator 1 May Link Physical Activity to Reduced Risk of Type 2 Diabetes: A Proteome-Wide Study of ARIC Participants. | Plasma Neuronal Growth Regulator 1 May Link Physical Activity to Reduced Risk of Type 2 Diabetes: A Proteome-Wide Study of ARIC Participants.
Steffen BT, McDonough DJ, Pankow JS, Tang W, Rooney MR, Demmer RT, Lutsey PL, Guan W, Gabriel KP, Palta P, Moser ED, Pereira MA., Free PMC Article | 01/30/2024 |
| CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p. | CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p.
Qiu L, He J, Chen H, Xu X, Tao Y. | 05/28/2022 |
| Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes. | Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes.
Leyden GM, Shapland CY, Davey Smith G, Sanderson E, Greenwood MP, Murphy D, Richardson TG., Free PMC Article | 03/5/2022 |
| Na/K-ATPase beta1-subunit associates with neuronal growth regulator 1 (NEGR1) to participate in intercellular interactions. | Na/K-ATPase beta1-subunit associates with neuronal growth regulator 1 (NEGR1) to participate in intercellular interactions.
Cheon Y, Yoo A, Seo H, Yun SY, Lee H, Lim H, Kim Y, Che L, Lee S., Free PMC Article | 10/16/2021 |
| Depression in multiple sclerosis patients associated with risk variant near NEGR1. | Depression in multiple sclerosis patients associated with risk variant near NEGR1.
Brugger SW, Gardner MC, Beales JT, Briggs F, Davis MF. | 07/24/2021 |
| Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females. | Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females.
Rana S, Mobin M., Free PMC Article | 06/12/2021 |
| Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. | Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children.
Breton E, Gagné-Ouellet V, Thibeault K, Guérin R, Van Lieshout R, Perron P, Hivert M, Bouchard L., Free PMC Article | 04/24/2021 |
| Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes. | Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
Venkannagari H, Kasper JM, Misra A, Rush SA, Fan S, Lee H, Sun H, Seshadrinathan S, Machius M, Hommel JD, Rudenko G., Free PMC Article | 03/13/2021 |
| Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder. | Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder.
Wang X, Cheng W, Zhu J, Yin H, Chang S, Yue W, Yu H. | 02/20/2021 |
| 1p31.1 microdeletion including only NEGR1 gene in two patients. | 1p31.1 microdeletion including only NEGR1 gene in two patients.
Tassano E, Uccella S, Giacomini T, Fiorio P, Tavella E, Malacarne M, Gimelli G, Coviello D, Ronchetto P. | 01/2/2021 |
| Polymorphisms in Neuronal Growth Regulator 1 and Otoancorin Alternate the Susceptibility to Lung Cancer in Chinese Nonsmoking Females. | Polymorphisms in Neuronal Growth Regulator 1 and Otoancorin Alternate the Susceptibility to Lung Cancer in Chinese Nonsmoking Females.
Zhang L, Tian W, Zhou B. | 10/3/2020 |
| analysis of genomic information from multiple non-cancer cohorts showed that both the NEGR1 promoter deletion and the BTNL3-8 deletion were CNVs occurring at high frequencies in the general population. Intriguingly, the upstream NEGR1 CNV deletion was homozygous in ~ 40% of individuals in the non-cancer population. | Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer.
Bobyn A, Zarrei M, Zhu Y, Hoffman M, Brenner D, Resnick AC, Scherer SW, Gallo M., Free PMC Article | 07/18/2020 |
| Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. | Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.
Antúnez-Ortiz DL, Flores-Alfaro E, Burguete-García AI, Bonnefond A, Peralta-Romero J, Froguel P, Espinoza-Rojo M, Cruz M., Free PMC Article | 03/3/2018 |
| NEGR1, strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings. | Psychiatric Genomics: An Update and an Agenda.
Sullivan PF, Agrawal A, Bulik CM, Andreassen OA, Børglum AD, Breen G, Cichon S, Edenberg HJ, Faraone SV, Gelernter J, Mathews CA, Nievergelt CM, Smoller JW, O'Donovan MC, Psychiatric Genomics Consortium., Free PMC Article | 02/10/2018 |
| Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder. | Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR., Free PMC Article | 09/9/2017 |
| Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes | Validation of obesity susceptibility loci identified by genome-wide association studies in early childhood in South Brazilian children.
Zandoná MR, Sangalli CN, Campagnolo PD, Vitolo MR, Almeida S, Mattevi VS. | 07/1/2017 |
| NEGR1 interacts with NPC2 and increases its protein stability; it has a role in obesity | The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking.
Kim H, Chun Y, Che L, Kim J, Lee S, Lee S. | 06/10/2017 |
| Genetic variants associated with BMI and WHR in adults influence growth patterns and general and abdominal fat development from early childhood onwards. | Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study.
Vogelezang S, Monnereau C, Gaillard R, Renders CM, Hofman A, Jaddoe VW, Felix JF. | 05/14/2016 |
| We observed novel selection signals in CDKAL1 and NEGR1, well-known diabetes and obesity susceptibility genes | Novel genomic signals of recent selection in an Ethiopian population.
Tekola-Ayele F, Adeyemo A, Chen G, Hailu E, Aseffa A, Davey G, Newport MJ, Rotimi CN., Free PMC Article | 04/30/2016 |
| NEGR1 could be an important locus influencing certain personality dimensions in BN patients. | Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders.
Gamero-Villarroel C, González LM, Gordillo I, Carrillo JA, García-Herráiz A, Flores I, Rodríguez-López R, Gervasini G. | 02/13/2016 |
| First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity. | Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
Dennis EL, Jahanshad N, Braskie MN, Warstadt NM, Hibar DP, Kohannim O, Nir TM, McMahon KL, de Zubicaray GI, Montgomery GW, Martin NG, Toga AW, Wright MJ, Thompson PM., Free PMC Article | 08/8/2015 |
| Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO gene and SNP rs2815752 near the NEGR1 gene. | Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.
Mägi R, Manning S, Yousseif A, Pucci A, Santini F, Karra E, Querci G, Pelosini C, McCarthy MI, Lindgren CM, Batterham RL., Free PMC Article | 08/23/2014 |
| Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. | Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology.
Bernhard F, Landgraf K, Klöting N, Berthold A, Büttner P, Friebe D, Kiess W, Kovacs P, Blüher M, Körner A. | 06/15/2013 |
| Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2. | The role of obesity-related genetic loci in insulin sensitivity.
Fall T, Arnlöv J, Berne C, Ingelsson E. | 11/17/2012 |