| we demonstrate an essential role for fructose 2,6-bisphosphate in the induction of glucose-6-phosphatase and other ChREBP target genes | Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L. | 05/26/2012 |
| An increase in G6Pase activity was observed in liver microsomes from rats starved overnight, which presented a ~15% decrease in hepatic Mg(2+) content. | Enhanced glucose 6-phosphatase activity in liver of rats exposed to Mg(2+)-deficient diet.
Barfell A, Crumbly A, Romani A., Free PMC Article | 07/16/2011 |
| Calorie restriction can inhibit the expressions of FoxO1, PEPCK and G-6-P, strengthen insulin signal conduction, suppress gluconeogenesis and thus regulate glycometabolism. | [The effect of calorie restriction on the expression of liver's gluconeogenesis genes of rats fed a high fat diet].
Luo MJ, Chen LL, Zheng J, Zeng TS, Deng XL. | 08/9/2010 |
| The lower sensitivity of the liver nuclear envelope G-6-Pase to N-ethylmaleimide suggests that the catalytic subunit of this system has some differences from the microsomal isoform. | [Glucose-6-phosphatase from nuclear envelope in rat liver].
González-Mujica F. | 01/21/2010 |
| The effect, which is lost when G6P has readily access to the ER lumen, requires physiological endoplasmic reticulum Mg(2+) content. | Biphasic effect of extra-reticular Mg2+ on hepatic G6P transport and hydrolysis.
Doleh L, Romani A., Free PMC Article | 01/21/2010 |
| A novel chimeric promoter, consisting of a 1.6 kb glucose 6-phosphatase promoter and a segment of the regulatory element derived from the L-type pyruvate kinase promoter, was designed to provide strong and tight control of insulin expression in liver. | Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells.
Lan MS, Wang HW, Chong J, Breslin MB. | 01/21/2010 |
| kinetic properties of the glucose 6-phosphatase of liver microsomes in adjuvant arthritis | Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats.
Kelmer-Bracht AM, Santos CP, Ishii-Iwamoto EL, Broetto-Biazon AC, Bracht A. | 01/21/2010 |
| Multiple, distinct cis-regulatory promoter elements are involved in the glucose response of the rat G-6-Pase gene. | The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK. | 01/21/2010 |
| glucose 6-phosphatase has a role in the small intestine in the control of glucose homeostasis [review] | A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis.
Mithieux G, Rajas F, Gautier-Stein A. | 01/21/2010 |
| HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine | Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.
Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F. | 01/21/2010 |
| G6pc expression was functionally silenced by adenovirus-mediated delivery of short hairpin RNA. | Functional silencing of hepatic microsomal glucose-6-phosphatase gene expression in vivo by adenovirus-mediated delivery of short hairpin RNA.
Huang A, Chen Y, Wang X, Zhao S, Su N, White DW. | 01/21/2010 |
| The effect of DYRK on the G6Pase promoter activity was produced by the isoforms DYRK1A and DYRK1B, but not by DYRK2 suggesting that DYRK1 is a specific co-activator of FKHR, independent of its kinase activity. | DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression.
von Groote-Bidlingmaier F, Schmoll D, Orth HM, Joost HG, Becker W, Barthel A. | 01/21/2010 |
| G6pc is down-regulated during liver gluconeogenesis. | Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?
Azzout-Marniche D, Gaudichon C, Blouet C, Bos C, Mathé V, Huneau JF, Tomé D. | 01/21/2010 |
| Fructose levels affect hepatic glucose-6-phosphatase catalytic subunit mRNA. | An acute increase in fructose concentration increases hepatic glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats.
Wei Y, Bizeau ME, Pagliassotti MJ. | 01/21/2010 |
| the cAMP responsiveness of the Glc6Pase promoter requires a tight cooperation between a proximal and a distal region, which depends on the presence of several HNF4alpha-, C/EBP-, and CREB-binding sites | A distal region involving hepatocyte nuclear factor 4alpha and CAAT/enhancer binding protein markedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter.
Gautier-Stein A, Mithieux G, Rajas F. | 01/21/2010 |
| dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation | Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation.
Deng X, Ewton DZ, Pawlikowski B, Maimone M, Friedman E. | 01/21/2010 |
| liver G-6-Pase activated in response to insulin-induced hypoglycemia or epinephrine infusion | Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat.
Bady I, Zitoun C, Guignot L, Mithieux G. | 01/21/2010 |
| glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells is regulated by short-chain fatty acids and HNF-4alpha | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha.
Massillon D, Arinze IJ, Xu C, Bone F. | 01/21/2010 |
| promoter activity suppressed by polyunsaturated fatty acyl coenzyme a | Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha.
Rajas F, Gautier A, Bady I, Montano S, Mithieux G. | 01/21/2010 |
| These observations, together with the absence of a conserved LXR-binding element within the G6Pase promoter, suggest an indirect inhibition of G6Pase gene expression by liver X receptors. | Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors.
Grempler R, Günther S, Steffensen KR, Nilsson M, Barthel A, Schmoll D, Walther R. | 01/21/2010 |
| The co-expression of glucose 6-phosphatase and cytosolic phosphoenolpyruvate carboxykinase was studied in the digestive system and the kidney of the rat. | Immunocytochemical localization of glucose 6-phosphatase and cytosolic phosphoenolpyruvate carboxykinase in gluconeogenic tissues reveals unsuspected metabolic zonation.
Rajas F, Jourdan-Pineau H, Stefanutti A, Mrad EA, Iynedjian PB, Mithieux G. | 01/21/2010 |