| findings demonstrated that the administration of exogenous G-CSF can improve cognitive function in a model of Cerebral small vessel diseases, possibly due to the recovery of endothelial and Blood Brain Barrier function. | Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain Barrier Damage and Improves Cognitive Function in Spontaneously Hypertensive Rats.
Wei X, Xu Y, Jin Y, Feng H, Xiao Y, Dong S. | 07/21/2018 |
| G-CSF treatment reduced body weight and increased energy expenditure in a diabetic model, and enhanced UCP-1 expression and decreased inflammatory cytokine levels may be associated with the effects of G-CSF treatment. | Anti-obesity effects of granulocyte-colony stimulating factor in Otsuka-Long-Evans-Tokushima fatty rats.
Lee Y, Song YS, Fang CH, So BI, Park JY, Joo HW, Park IH, Shen GY, Shin JH, Kim H, Ahn YH, Kim KS., Free PMC Article | 11/14/2015 |
| The use of G-CSF to protect the vasculature may improve the clinical outcome of tPA even outside the currently indicated therapeutic window for ischemic stroke. | Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis.
dela Peña IC, Yoo A, Tajiri N, Acosta SA, Ji X, Kaneko Y, Borlongan CV., Free PMC Article | 04/11/2015 |
| G-CSF can prevent the progression of DN in OLETF rats and its effects may be due to mobilization of BM cells rather than being a direct effect. | G-CSF prevents progression of diabetic nephropathy in rat.
So BI, Song YS, Fang CH, Park JY, Lee Y, Shin JH, Kim H, Kim KS., Free PMC Article | 05/31/2014 |
| In conclusion, G-CSF induced LBP expression could serve as a new model for investigation of LPS sensitization. We demonstrated the crucial role of LBP upregulation in pathogenesis of LPS induced SIRS. | Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.
Fang H, Liu A, Sun J, Kitz A, Dirsch O, Dahmen U., Free PMC Article | 09/14/2013 |
| G-CSF protects oligodendrocyte from SCI-induced cell death via the suppression of inflammatory cytokines and up-regulation of anti-apoptotic protein | Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats.
Kadota R, Koda M, Kawabe J, Hashimoto M, Nishio Y, Mannoji C, Miyashita T, Furuya T, Okawa A, Takahashi K, Yamazaki M., Free PMC Article | 06/29/2013 |
| G-CSF has an influence on the stability of presynaptic terminals in the spinal cord as well as on the astroglial reaction, indicating a possible neuroprotective action. | Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion.
De Freria CM, Barbizan R, De Oliveira AL. | 08/25/2012 |
| These findings extend current knowledge regarding the role of SCF and G-CSF in the regulation of neurogenesis and provide insights into the contribution of hematopoietic growth factors to brain development and remodeling | Stem cell factor and granulocyte colony-stimulating factor promote neuronal lineage commitment of neural stem cells.
Piao CS, Li B, Zhang LJ, Zhao LR. | 03/24/2012 |
| Granulocyte-colony stimulating factor (G-CSF) facilitates hepatic regeneration by increasing the migration of bone marrow progenitors to the liver, as well as enhancing the endogenous oval cell reaction. | Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.
Piscaglia AC, Shupe TD, Oh SH, Gasbarrini A, Petersen BE., Free PMC Article | 12/5/2011 |
| Epo combined with granulocyte colonystimulating factor enhanced Mmp2 expression in mesenchymal stem cells, promoted motility and activated the ERK1/2 signaling pathway. | Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration.
Yu Q, Chen L, You Y, Zou C, Zhang Y, Liu Q, Cheng F. | 08/6/2011 |
| These findings suggest that granulocyte-colony stimulating factor could act directly on cardiac mitochondria to prevent mitochondrial dysfunction caused by oxidative stress. | Granulocyte-colony stimulating factor attenuates mitochondrial dysfunction induced by oxidative stress in cardiac mitochondria.
Thummasorn S, Kumfu S, Chattipakorn S, Chattipakorn N. | 07/30/2011 |